Term
| Ingestion of ____ gm of salicylate or ___ ml of methyl salicylate can cause death in children. |
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Definition
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Term
| What should be done to determine the best form of salicylate treatment therapy? |
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Definition
1. measure serum salicylate 2. measure serum pH |
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Term
| Is symptomatic treatment sufficient in the mild form of salicylate intoxication? |
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Definition
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Term
| ______ urinary pH promotes the excretion of salicylate. |
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Definition
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Term
| What are three mandatory actions to treat severe cases of salicylate intoxication? |
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Definition
1. Intravenous administration of fluid 2. Dialysis (hemidialysis or peritoneal) 3. Frequent assessment and correction of acid base and electrolyte balance. |
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Term
| What are the seven NSAIDs derived from propionic acid in order of market availability? |
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Definition
1. Ibuprofen 2. Naproxen (Naprosyn) 3. Naproxen. Na (Anapox.) 4. Flubiprofen 5. Ketoprofen 6. Oxaprozin 7. Carboprofin |
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Term
| Propionic acid derived NSAIDs possess anti-inflammatory, antipyretic, and analgesic activity like salicylates but have less intense ____ ____ |
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Definition
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Term
| What class of NSAIDs are the drugs of choice in treating rheumatoid arthritis? What else are they often used to treat due to their analgesic effect? |
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Definition
1. salicylates 1. headaches 2. myalgia 3. arthralgia |
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Term
| How do propionic acid derivatives bind to cyclo-oxygenase? |
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Definition
| reversibly unlike aspirin and salicylates such as diflusinal which bind irreversibly |
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Term
| What percentage of propionic acid derivatives are bound to serum albumin? |
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Definition
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Term
| Which propionic acid derivative exhibits the longest half life? |
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Definition
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Term
| What are the CNS side effects of propionic acid derivatives? |
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Definition
1. Headache 2. Dizziness 3. Tinnitus |
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Term
| Name three NSAIDs that are acetic acid derivatives? |
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Definition
- Indomethacin
- Sulindac
- Etodolac
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Term
| Despite its potency as an anti-inflammatory agent the _____ of indomethacin limits its use to the treatment of gouty arthritis. |
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Definition
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Term
| How do indolacetic acid drugs bind cyclo-oxygenase? |
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Definition
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Term
| Are the acetic acid derivative NSAIDs more potent as anti-inflammatory agents than salicylates? |
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Definition
| Yes, but they are not as well tolerated at the dosage required. |
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Term
| Name three conditions in which acetic acid derived NSAIDs are more effective in treating inflammation than ASA or the other NSAIDs? |
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Definition
- acute gouty arthritis
- ankylosing spondylitis
- osteoarthritis of the hip
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Term
| Name two ocular conditions that indolacetic acid is used for? |
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Definition
| controlling pain with uveitis and post-ophthalmic procedures |
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Term
| What effect does indolacetic acid have on uterine contractions? |
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Definition
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Term
| What are six adverse effects of indolacetic acid? |
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Definition
1. gastro-intestinal 2. nausea 3. vomitting 4. anorexia 5. diarrhea 6. abdominal pain |
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Term
| How often do adverse effects of indolacetic acid occur? |
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Definition
| Occurs in up to 50 % of patients treated |
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Term
| What percentage of patients treated with indolacetic acid cannot tolerate the adverse effects and discontinue use? |
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Definition
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Term
| What are the adverse effects of indoacetic acid related to? |
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Definition
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Term
| One adverse gastrointestinal effect of indolacetic acid ulceration of the ____ GI tract can occur sometimes with _____ and _______ |
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Definition
1. upper 2. perforation 3. hemmorrhage |
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Term
What is the most severe CNS side effect of indoacetic acid and how often does it occur? |
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Definition
frontal headache, occurs in 25-50% of patients who chronically use the drug |
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Term
| What percentage cross sensitivity does indolacetic acid show with ASA? |
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Definition
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Term
What adverse hematopoietic effects does indolacetic acid show? |
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Definition
1. neutropenia 2. thrombocytopenia 3. rarely aplastic anemia |
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Term
| What effect does indomethacin have on the antihypertensive drugs, such as beta blockers, furosemide, thiazide diuretics, and ACE inhibitors? |
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Definition
| decreases the anti-hypertensive effect |
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Term
| What is the only oxicam derivative drug available in the U.S.A.? |
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Definition
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Term
| What ion do oxicam derivatives interfere with the excretion of? |
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Definition
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Term
| What is the side effect of fenamates? |
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Definition
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