Term
| Preformed releasing factors include ____, ____, _____, such as chymase and tryptase. |
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Definition
histamine proteoglycans serine proteases |
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Term
| Newly formed mediators include ______, _____, and ______. |
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Definition
leukotrienes prostaglandins platelet activating factor |
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Term
| During an allergic event ____ mast cells migrate to a more superficial layer. |
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Definition
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Term
| There are _____ mast cells in the human eye. |
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Definition
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Term
| What is the primary cell involved in the allergic response of the body? |
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Definition
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Term
| Mast cell degranulation releases ____ and other ______ mediators in the eye. |
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Definition
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Term
| The mature mast cells share many characteristics with _____ but unlike _____ are not found in the _____. |
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Definition
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Term
| The most anatomically striking feature of the mast cell is the large number of ______ that secrete and store chemical messengers. |
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Definition
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Term
| ______ allergic signs and symptoms occur when existing mediators that reside within the mast cell are released during _____ or when mediators are _______ due to _______. |
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Definition
Ocular degranulation synthesized degranulation |
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Term
| What are the two different types of mast cells and where are they located in the body? |
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Definition
- T (Tryptase containing mast cells) intestinal mucosa
- TC (Tryptase chymase containing mast cells) connective tissue and conjunctiva
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Term
| Name two prophylactic mast cell stabilizers that are not useful in treating acute allergic reactions. |
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Definition
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Term
| The binding of the antigen to the IgE molecules of the _____ ___ and _____ activates the release of ____ that triggers the release of _____, _____, and other inflammatory mediators. |
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Definition
mast cells basophils Ca2+ histamines and bradykinins |
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Term
| By what method is cromolyn or nedocromil administered for asthma? What is the time of onset? |
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Definition
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Term
| What are two minor adverse effects of mast cell stabilizers? |
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Definition
Bitter taste irritation of the larynx and pharynx |
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Term
| Name one tricyclic dibenzoxepin? |
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Definition
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Term
| Carboxamine, clemastine, diphenhydramine, and dimenhydrinate belong to the class of antihistamines called ____. |
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Definition
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Term
| Pyrilamine and Tripelennamine belong to the class of antihistamines called _____. |
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Definition
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Term
| Chlorpheniramine and Brompheniramine belong to the class of antihistamines called ______. |
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Definition
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Term
| Hydroxyzine, cyclizine, and meclizine belong to the class of antihistamines called ______. |
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Definition
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Term
| Promethazine belongs to the antihistamine class called the _____. |
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Definition
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Term
| Cyproheptaidine and phenoindamine belong to the anti-histamine class called the ______. |
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Definition
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Term
| The second generation H-1 receptor blocker that belongs to the alkylamines is ______. |
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Definition
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Term
| The second generation H1 receptor blocker that belongs to the piperazines is called ______, which has now been replaced by _______. |
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Definition
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