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Opt 211 Pathology Connor
Cancer Leukimia 10/15/07
23
Other
Not Applicable
10/29/2007

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Term
Leukimia is a cancer that begins where?
Definition
the blood cells
Term
What do you call blood that flows through the heart and blood vessels?
Definition
Peripheral blood
Term
What is an immature blood cell called?
Definition
blasts or stem cells
Term
How does leukimia damage the body?
Definition

The abnormal WBCs crowd out the normal WBCs, RBCs, and platelets and make it difficult for the blood to function.

Term
Which type of leukimia has a predominance of immature blast cells?
Definition
acute leukimia
Term
Which type of leukimia has mature cells?
Definition
chronic
Term

In which type of leukimia does the patient die quickly?

Definition
acute
Term
What type of leukimia is more common in children?
Definition
acute
Term
Would a painless lymph node more likely be malignant or benign?
Definition
malignant, the painful ones are probably due to infection
Term
What are the symptoms of leukimia?
Definition
ANT

Anemia
Neutropenia
Thrombocytopenia
Term
What are the two pre-proliferative conditions?
Definition
1)  (MPS) myeloproliferative syndrome
2)  (MDS) myelodysplastic syndrome
Term
What are the clinical features of leukimia?
Definition
1)  anemia (low RBC)
2)  fever (low WBC)
3)  bleeding tendency (low PLT)
4)  tender bones, lymphadenopathy, splenomegaly (Leukimic infiltration)
Term
What is Burkitt's lymphoma a tumour of?
Definition
mature B cells
Term
Where does Burkitt's lymphoma usually arise?
Definition
extranodal sites
Term
Burkitt's lymphoma is uniformly associated with translocations of what proto-oncogene?
Definition
c-MYC, a proto-oncogene is a gene that can become an oncogene through increased expression.  An oncogene is a modified gene or set of nucleotides that codes for a protein and is thought to cause cancer.
Term
Burkitt's lymphoma is latently associated with infection by what virus? 
Definition
Epstein-Barr virus
Term
Which type of lymphoma features Reed Sternberg cells and eosinophilia?
Definition
Hodgkins lymphoma, the curable one, as opposed to non Hodgkins lymphoma that is not characterized by Reed Sternberg cell or eosinophilia
Term
What cells are Reed Sternberg cells derived from?
Definition
Beta lymphocytes
Term
In which type of lymphoma is there a detectable pattern of the tumour through the lymph node?
Definition
NonHodgkins
           follicular lymphoma
Term
Which white blood cell cancer involves a more mature lymphocyte than either leukimia or lymphoma?
Definition
multiple myeloma
Term
What type of cancer comes in old age, is due to malignancy of the Plasma cells, specifically B lymphocytes, characterized by lytic bone lesions, marked antibody production of monoclonal antibodies, hyper gammaglobulinemia leading to blindness, and immunod
Definition
myeloma
Term
Which type of cancer involves enlargement of the liver and spleen?
Definition
leukimia, both leukimia and lymphadenopathy involve lymph node swelling
Term
What disorder causes blood to clot inappropriately in the capillaries yet blood won't clot in cases of trauma
Definition
Thrombotic thrombocytopenic Purpura
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