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25-Opportunistic Infections
HIV OIs
29
Chemistry
Graduate
04/02/2019

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Cards

Term
Primary Prophylaxis PCP START/STOP
Definition
CD4: <200 CD4% <14% STOP: When CD4 >200 x 3mnths
Term
Primary Prophylaxis
PCP Rx and Dose
Definition
Septra DS or SS 1 PO D
Term
Primary Prophylaxis
TE START/STOP
Definition
CD4:<100
&
Toxo IgG+
STOP: When CD4 >200 x 3mnths
Term
Primary Prophylaxis
TE Rx and Dose
Definition
Septra DS 1 PO D
Term
Primary Prophylaxis
MAC START/STOP
Definition
CD4:<50
ONLY if not recieving ART
STOP: When starting effective ART
Term
Primary Prophylaxis
MAC Rx and Dose
Definition
Azithromycin 1200mg PO weekly OR
Azithromycin 600mg PO 2 times a week OR
Clarithromycin 500mg PO BID
Term
SEPTRA SFX
Definition
RASH
GI
HYPERKALEMIA
Term
DAPSONE & PRIMAQUINE SFX
Definition
RASH
METHEMOGLOBINEMIA(G6PD deficiency)
Term
Pyrimethamine SFX
Definition
PANCYTOPENIA
RASH
Term
PENTAMIDINE SFX
Definition
RESP SXs
NEPHROTOXIC
Term
ATOVAQUONE SFX
Definition
RASH
HA
GI
Term
AZITHROMYCIN/CLARITHROMYCIN SFX
Definition
GI
Term
ETHAMBUTOL SFX
Definition
OPTIC NEURITIS
NEUROPATHY
HA
GI
Term
AMPHOTERICIN B SFX
Definition
NEPHROTOXIC
INFUSION-RELATED RXNs
Term
FLUCYTOSINE SFX
Definition
BONE MARROW SUPPRESS
GI
Term
FLUCONAZOLE SFX
Definition
GI
HEPATOTOXIC
Term
TREATMENT Mild-Mod
PCP Rx and Dose
Definition
Septra 15-20mg/kg/day PO in 3 divided doses
OR
Septra DS 2 Tabs PO TID
Term
TREATMENT Mod-SEVERE
PCP Rx and Dose
Definition
Septra 15-20mg/kg/day IV q6-8H then switch to PO when improved clinically
Term
TREATMENT TE
Definition

Pyramethamine 200mg PO once then </=60kg:Pyramethamine 50mg PO D +Sulfadiazine 1000mg po q6h +leucovorin 10-25mg PO D

>60kg:Pyramethamine 75mg PO D +Sulfadiazine 1500mg po q6h +leucovorin 10-25mg PO D

Term
TE Transmission from
Definition
undercooked meats
cat feces
Term
PCP Dx
Definition
Bronchoalveolar lavage
CT scan: Ground glass
CHest X-ray: diffuse bilateral/symmetric ground glass
Term
PCP Treatment Duration
Definition
21 days
Term
TE treatment duration
Definition
At least 6 weeks
Term
MAC treatment duration
Definition
At LEAST 12 months
Term
MAC Treatment
Definition
-Clarithromycin 500mg PO BID & Ethambutol 15mg/kg PO D {PREFERRED**}
OR
-Azithromycin 500-600mg PO D & Ethambutol 15mg/kg PO D
Term
Cryptococcosis Treatment
Definition
Liposomal Amphotericin B 3-4mg/kg IV D + Flucytosine 100mg/kg PO D in 4 divided doses
Term
Vaccines if CD4+ >200
Definition
MMR and
Varicella
Term
Vaccines for all HIV Pts
Definition
Influenza TDAP/TD
H. Influenzae(Hib) Meningitis
HPV Pneumococcal
Hep A/B
Term
What is IRIS?
Definition
Immune reconstitution Inflammatory Syndrome
-Unmasking: revealing unknown(subclinical)
-OI:may be worse than usual presentation
[hi risk if CD4+ <50]
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