Term
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Definition
| Strong Agonist @ mu opioid receptor (high 1st pass) |
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Term
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Definition
-Resp depression
-Analgesia, euphoria, sedation
-cough suppression
-Constipation
-Mast cell degranulation
-Bronchoconstriction and hypoTN (Do NOT USE with Asthma) |
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Term
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Definition
-HTN crisis with MAO inhibitors
-Phenothiazines antagonize analgesia
-Other CNS depressants |
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Term
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Definition
-Resp depression and CO2 retention (increase cerebral pressure causing ischemia there and in spine)
-Convulsions in infants |
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Term
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Definition
Strong opioid agonist with long half-life
-used for detox |
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Term
| Methadone Drug interactions |
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Definition
-Cimetidine adds to sedations (used for peptic ulcers)
-Rifampin (TB tx) causes lower blood levels of methadone |
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Term
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Definition
Strong Opioid agonist
-shorter duration of action than morphine
-No pinpoint pupils (dilates) and no cough suppression
-Metabolized to Normeperidine (causes CNS excitability) |
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Term
| Meperidine Drug interactions |
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Definition
-aminophylline, pentobarbital/thiopental, heparin, methicillin, NaHCO3
-Alcohol
-Cimetidine causes additive sedation and CNS depression
-MAO inhibitors HTN crisis
-Phenytoin increase toxic effect of normeperidine |
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Term
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Definition
-antimuscarinic (contraindicated w/ tachy)
-Cardiac arrest(negative inotropic axn)
-Resp depression
-Normeperidine build-up = seizures |
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Term
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Definition
Strong Opioid Agonist
-More potent and fast acting than morphine |
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Term
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Definition
-Incompatible w/ thiopental/pentobarbital
-MAOi HTN crisis |
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Term
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Definition
-Arrhthmias (bradycard/circ depression)
-bronchoconstriction
-Resp depression |
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Term
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Definition
Mild Opioid Agonist
-Less effective (used with tylenol)
-Anti-tussive and anti-diarrheal agent
-^ oral availability |
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Term
| Codeine Drug Interactions (Sfx) |
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Definition
-Coma possible with Chlordiazepoxide'
-Circ collapse, convulsions, anaphylactoid |
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Term
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Definition
Mild Opioid Agonist
-Similar to codeine (more addictive) |
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Term
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Definition
Mild Opioid Agonist
-No antitussive
-Alters perception and emotional responses to pain
-Way more potent than codeine
-Post-op
Sfx: Hepatotoxicity |
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Term
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Definition
Mild Opioid Agonist
-Similar to methadone structure (depress resp)
Interactions: Fatal w/ Alcohol
-Increase Warfarin effects
-Increase toxicity of carbamazepine |
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Term
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Definition
Mixed Opioid receptor agonist
-partial mu ag (30x potency of morphine)
-kappa antag (3x action naloxone)
-Long action (slow dissociation from mu)
Tx: Post-op pain, cancer, trauma, MI pain, Trigem neuralgia... Reduce opioid addiction and REverse fentanyl-induced anasthesia
Sfx: Resp and Cardio collapse with Diazepam |
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Term
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Definition
Mixed agonist @ opioid
-kappa agonist
-weak antag at mu and delta
-used to treat moderate pain (kappa activity)
-mu dependent can precipitate withdrawal syndromes
Sfx: hallucinations/nightmares, decrease renal plasma flow, ^BP ^cardiac workload (DO not give if someone might have MI) |
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Term
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Definition
Central Acting Mixed Opioid Receptor Ag
-Inhibits NE and Serotonin re-uptake
-weak mu receptor agonist |
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Term
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Definition
-Carbamazepine increases tramadol levels
-Increase adverse effects of MAOi
Sfx:Urine retention, constipation, anxiety, anorexia, Rash |
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Term
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Definition
Opioid Antagonist
-Used in life-threatening situations (short half-life)for narcotic overdose
Sfx: Analgesia reversal, rapid reversal may cause sweating, arrhythmia, nausea vomiting |
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Term
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Definition
Opioid Antagonist (long acting)
-Useful in detoxification
Sfx: possible life-threatening hepatotoxicity |
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Term
| Methadone opioid replacement therapy |
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Definition
-longer but less severe withdrawal (long half-life)
- |
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