Term
| What are the three principal opioid receptors? |
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Definition
| μ (mu) κ (kappa) δ (delta) |
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Term
| 1. What are the endogenous substances that morphine and other opioid agonists mimic? |
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Definition
| Endorphins, enkephalins and dynorphins. |
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Term
| List two CNS effects of opioids. |
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Definition
| Analgesia, dysphoria/euphoria, drowsiness, respiratory depression, depression of the cough reflex (antitussive), Inhibits release of ACTH and gonadotrophin, increases the release of ADH, miosis, stimulates CTZ. |
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Term
| Where does enkephalin biosynthesis take place? |
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Definition
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Term
| What class (type) of receptors do the opioid receptors belong to? |
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Definition
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Term
| How is enkephalinergic neurotransmission terminated? |
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Definition
| By the actions of a protease (enkephalinase) which cleaves the pentapeptide between Gly3 and Phe4. |
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