Term
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Definition
Narcan
Revex
Used for opioid OD |
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Term
| Actions of opioid antagonists |
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Definition
| Have greater affinity for cell receptors that the opioids drug (agoist), blocks agoist/opioids; reverses effect of opioids, including pain relief |
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Term
| Uses of opiod antagonists |
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Definition
| To reverse adverse opioids effects; effect sometimes shorter than original opioids, so may need multiple doses |
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Term
| Adverse reactions opioid antagonists |
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Definition
- Naus/vom (N/V),
- sweating
- tachycardia
- up BP
- Tremors
- sudden bolus may cause sudden return of pain, may be best to give slowly.
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Term
| Contraindications of opioid antagonists |
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Definition
| Only hypersensitivity listed |
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Term
| Precautions opioid antagonists |
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Definition
- Preg catg B – use cautiously
- Cautious use in opioids dependent infants
- Cautious use in those with CV disease
- May produce withdrawal symptoms for those physically dependent on opioids
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Term
| Pre and ongoing assessment of pt receiving opioid antagonist drug |
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Definition
- Baseline vitals,
- review record for suspected cause (what opioid?)
- If time, review health hx, allergies, etc.
- Monitor BP-P-R q 5 min until responds
- Afterwards q 5-15 min
- Monitor for adverse rxn and notify PCP
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Term
| Considerations re pt with opioid OD and use of antagonist to treat |
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Definition
- For “Impaired Spontaneous Ventilation” may use artificial ventilation; maintain patent airway
- Pt may rq suctioning b/c N/V of antagonist
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Term
| What are the two opioid antagonists? |
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Definition
naloxone (Narcan)
nalmefene (Revex) |
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