Term
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Definition
act on the same receptors as the primary alkaloids of opium "opiods"
mimic actions of the CNS neurochemicals called enkephalins and endorphins in relieving pain and producing other related effects
are antagonized by naloxone and related antagonists |
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Term
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Definition
"opioid" resemble natural alkaloids of opium, morphine, and codeine
"narcotic analgesic" misleading legally, narcotic literally means "sleep producing" |
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Term
| synaptic actions of opioids- presynaptic |
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Definition
peptide synthesis and microtubule transport
processing by peptidase and packaging
cell firing and release of peptides (endogenous opioids)
-responding to pain or stress |
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Term
| synaptic actions of opioids- postsynaptic |
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Definition
endogenous or exogenous opioids bind postsynaptic receptors and activate 2nd messengers
-inhibition of adenylyl cyclase and decrease of intracellular cAMP
-activation of K+ channels; efflux of K+ hyperpolarize cells
endogenous opioids are inactivated by membrane-bound endopeptidases
exogenous opioids are metabolized and eliminated |
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