Term
| What NSAID has the lowest risk of CV Effects |
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Definition
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Term
| What is the first cell affected by low dose Aspirin |
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Definition
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Term
| What are the adverse effects and their mechanisms of Aspirin |
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Definition
GI Upset: Lower PGE2 increases Acid and decreases mucous
Hypersensitivity: Nasal Polyps
Reye's Syndrome: Associated with use in viral infections(Encephalitis and Fatty Liver)
Gout: precipitate episodes
Salicylism: Uncouple Ox Phos-> Compensated Respiratory Acidosis
Toxic-> Uncompensated Respiratory Acidosis-> increase Aspirin brain absorption
Acute Renal Failure: In disease States |
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Term
| How do you treat salicylism |
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Definition
Rehydrate
Alkalization
Hemodialysis |
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Term
| How do you prevent the GI complications of Aspirin? |
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Definition
Misoprostol: PG agonist
PPI's |
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Term
| What are the adverse effects of Acetominophen and how are they treated? |
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Definition
Liver toxicity: p450, then Gltuathione
(Depletes glutathione-> ROS damage)
Rx: N-Acetyl Cysteine |
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Term
| What is the mechanism of Acetominophen |
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Definition
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Term
| What is the mechanism of action of Tramadol |
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Definition
| Weak opiod, Blocks NE and Serotonin Uptake |
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Term
| What is Indomethacin used for and what are the adverse effects |
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Definition
Use: Close Patent Ductus, Bad Arthritis
Adverse: Sigificant GI tox |
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Term
| What is ketorolac used for and how is it administered |
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Definition
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Term
| What are some differences between Aspirin and the other NSAIDS? |
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Definition
Non-Aspirins are Reversible
More analgesic
No Gout attacks or Acid-Base disturbances
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Term
| What are the complications of excessive analgesic use? |
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Definition
Chronic Morning Headaches
Low Pain Threshold |
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Term
| What is the treatment of choice for Arthritis |
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Definition
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Term
| What NSAID's are Antipyrictic, Analgesic, Anti-Inflamatory |
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Definition
Aspirin: All
Ibuprofen: All
Naproxen:All
Acetominophen: all except Anti-inflamatory
Tramadol: Just Analgesic
Ketorolac: Just Analgesic |
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