Term
| What are the receptors for the eicosanoids |
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Definition
Prostaglandins bind Gs-(cAMP)-Relaxation
Thromboxanes bid Gq-(Ca)-Contraction |
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Term
| What is the role of the eicosanoids in inflammation |
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Definition
PGE2 raises body temperation
Prostaglandins induce vasodilation, Post cap-venule leakiness
Thromboxanes: Chemoattractant for WBC
IL-1B induces COX-2 and PGE Synthase
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Term
| What is Prostaglandin effects on Female and male reproductive systems, Sleep and the eye |
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Definition
Male: PGE/PGF-> Fertility
Female: PGE and PGF Oxytocic
Sleep: PGD induces normal sleep
Eye: PgE and PGF decrease ocular pressure |
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Term
| What are the effects of Leukotrienes on the heart GI, and Blood cells |
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Definition
Heart: HETE SM chemoattractant, LTC/LTD decrease contractility and coronary flow
GI: LTB Chemoattract poly's
Blood Cells: LTB-Chemoattract poly's, LTD/LTC-Chemoattract Eosinophils
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Term
| What is the mechanism of Zileuton, Zafirlucast, and Montelucast |
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Definition
Zileuton: 5-LO Inhibitor
Zafir and Monte: CystLT1 Inhibitor |
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Term
| What is the drug of choice in Primary dysmenorrhea? |
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Definition
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Term
| What is donoprostone used for and what is the mechanism? |
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Definition
Synthetic PGE2
Abortion and Labor Induction
Uterine contractions and Cervical softening |
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Term
| What is Epoprostenol and what is it used for |
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Definition
| Prostacyclin used in Pulm HPTN |
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Term
| What is Misoprostol and what is it used for |
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Definition
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Term
| What is Latanoprost and what is it used for |
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Definition
| PGF2a derivative used for glaucoma |
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Term
| What is Carboprost and what is it used for |
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Definition
| PGF2a Analog used for 2nd trimester abortion or Post-partum Bleeding |
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Term
| Why do Omega-3 FAs help to prevent a cardiovascular problem |
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Definition
| PGI3 is more potent than TXA3, leading to less vasoconstriction and platelet aggregation |
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