Term
| What are the muscle relaxants that act on GABA receptors and what are the pharmacodynamics of each |
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Definition
Benzodiazepines: GABA-A:Increase Cl conductance(Ia=Efflux, Motor=Influx)
Baclofen: GABA-B: Increase K Conductance, decrease Ca Influx
Decrease Substance P-> less pain
Gabapentin: Antiepileptic |
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Term
| What is the mechanism of action of Tizanidine and what are the side effects? |
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Definition
Alpha 2 and Imidazoline Agonist
More Central than Peripheral
Sides: Dry mouth, Hypotension, Sedation |
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Term
| How is Baclofen administered and what are the side effects |
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Definition
Intrathecal Admin
Sides:Seizures if Oral dose withdrawn rapidly,
Teratogenic |
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Term
| What is the mechanism of Dantrolene and what are its uses |
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Definition
Blocks Ryanodine Ca Conductance in Skeletal muscle
Use: Malignant Hyperthermia, Muscle Relaxant |
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Term
| What is the mechanism or action and use of Cyclobenaprine |
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Definition
Decrease Serotonergics
Use: Local Trauma, Muscle Strains |
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Term
| What are the adverse effects of Cyclobenzoprime |
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Definition
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Term
| Which relaxants are anti-spastic and spasmotic |
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Definition
Both: Benodiazepine, Tirazidine
Spastic: Beclofen, Dantrolene
Spasmodic:Cycolbenaprime |
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