Term
| What is the mechanism of Action of each of the Antifungals? |
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Definition
Polylenes: Bind Ergosterol
Echinocandins: Block B1,3-Glucan Synthase
Azoles: Block Fungal P450
5-Flucytosine: Block DNA and RNA synthesis
Terbinafine: Block Squalene Epoxidase
Griseofulvin: Inhibits Microtubule formation (Mitosis)
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Term
| What is the mechanism and the adverse effects of Polyenes? |
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Definition
Bind Ergosterol
Adverse:Nephrotoxic
Electrolyte Wasting
Infusion Rxns |
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Term
| What is the mechanism and adverse effects of Echinocandins |
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Definition
1,3Beta-glycan Synthase Inhibition
Adverse: Hepatotoxic
Phlebitis
Expensive |
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Term
| What is the mechanism and the adverse effects of the Azoles |
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Definition
Block fungal P450
Adverse:Hepatotoxic |
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Term
| What is the mechanism and the adverse effects of 5-Flucytosine? |
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Definition
Block DNA synthesis and RNA Transcription
Adverse: Marrow Suppression
Hepatotoxic |
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Term
| What is the mechanism and the adverse effects of Terbinafine |
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Definition
Blocks Squalene Epoxidase
Adverse:Hepatotoxic
Neutropenia
Stephen's Johnson Syndrome |
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Term
| What is the mechanism and the adverse effects of Griseofulvin |
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Definition
Inhibits Microtubules Blocking Mitosis
Adverse: CNS (Headaches) |
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Term
| What is the drug of choice for Aspergillus infection? |
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Definition
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Term
| What are the formulations of Amphotericin and what is their purpose |
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Definition
Reduce Toxicity
Nephrotoxicity: ABCD=ABC>LAmB
Infusion Rxn: ABCD>ABC>LAmB
ABCD:AB colloidal dispersion
ABLC:AB Lipid Complex
LAmB: Liposomal AB |
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Term
| What are the echinocandins |
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Definition
Caspofungin
Micafungin
Anidulafungin |
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Term
| What is spectrum of activity for the Azoles? |
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Definition
Fluconazole: Yeast(Candida, Cryptococcus), not Glabrata, Krusei, or Aspergillus
Intraconizole: Yeast(Candida, Cryptococcus), Aspergillus
Voriconazole: Yeast(Candida, Cryptococcus), Aspergillus, Black Molds
Posaconazole: Yeast, Aspergillus, Zygomyces
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Term
| What is the spectrum of the Polyenes |
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Definition
Yeasts: Candida (Not Lusitaniae), Cryptococcus
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Term
| What is the spectrum of the Echinocandins |
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Definition
Cidal vs Yeast: Candida
Aspergillus
Not to Cryptococcus or Parapsitosis |
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Term
| What is the spectrum of 5-Flucytosine |
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Definition
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Term
| What is the spectrum of Terbinafine and Griseofulvin |
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Definition
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Term
| What are the antifungals used in Glabrata, Lusitaniae, Krusei, Parapsitosis |
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Definition
Glabrata: 5-FU or Candins
Lusitaniana: Anything but Ampho B
Krusei: Voriconazole, Posaconazole, Candins
Parapsitosis: Anything but Candins |
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Term
| Which systemic antifungal is not effective against Cryptococcus |
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Definition
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Term
| What should be taken with Posaconazole |
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Definition
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Term
| What should you be cognizant of with Voriconazole and Terbinafine use |
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Definition
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Term
| What anti-fungal and what rheumatoid drug is contra-indicated in CHF |
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Definition
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