Shared Flashcard Set

Details

Ophtho/Derm/Rheum-Path
Bone Tumors
24
Pathology
Graduate
11/30/2010

Additional Pathology Flashcards

 


 

Cards

Term
What is the most common tumor found in bone
Definition

Malignant Metastasis

Then Hematopoeitic malignancies

Term

What are the most common Primary bone Malignancies found in the following age groups

0-10, 10-20, 20-40,40-60

Definition

0-10: Ewing's

10-20: Osteosarcoma, Ewing's

20-40: Chondrosarcoma

40-60: Mets

Term
What are the radiological Indicators of benign versus malignant
Definition

Benign: Sharp Margin

Sclerotic

Malignant: Onion Skining(Ewing's)

Codman's Triangle(Osteosarcoma)

Spiculated

Osteoid Deposition

Term
What information is typically used to diagnose a bone tumor
Definition

Clinical

Radiologic

Histology

Term
Classify the bone tumors by origin
Definition

Epiphysis: Giant Cell

Chondroblastoma

Upper Metaphysis: Osteosarcoma

Osteoblastoma

Enchondroma

Diaphysis: Ewing's

Lymphoma/Myeloma

Term
What are the indications of a sclerotic verses a ratty/fuzzy margin of a bone tumor
Definition

Sclerotic: Benign

Fuzzy: malignant

Term
What circumstance would you suspect a metastatic lesion over and primary bone tumor
Definition

Older Patient

Multiple Foci

Axial or Proximal limb location

Term
What is a Non-ossifying Fibroma and who is most likely to get it
Definition

Kids

Most likely a metaphyseal fibrous defect which can lead to pathological fracture

Reddish Brown

Term
What is fibrous dysplasia and who is most likely to get it
Definition

Young Adults

Chinese characters formed by bony spicules

Term
What is Albright's (McCune's) Syndrome
Definition

Polystotis Fibrous dysplasia

Cutaneous Pigments(Cafe au Lait)

Endocrine Disturbances(Early Puberty)

Term
What is Osteochondroma and who is likely to get it
Definition

M>F

Epiphyseal defect leading to bone growth out and toward metaphysis (Benign)

Term
What is Multiple Heriditary Exostasis
Definition
Autosomal dominant disease with multiple Osteochondromas
Term
What is Osteoid Osteoma and who is likely to get it and how is it treated
Definition

M>F, Teens-20's

Prostaglandin Porducing Tumor-NSAID Relief

Looks like Osteogenic Sarcoma

Rx: Remove Surgically

Term
What is Osteoblastoma and who does it affect
Definition

Teens-20s

Large Version of Osteoid Osteoma occuring primarily in Axial skeleton

Term
What is an osteosarcoma and who does it typically affect
Definition

M>F Elderly with History of previous bone disease or Teenagers

Fuzzy irregular, Codman's Triangle, Malignant osteoid(Pink Amorphous)

Term
Where do osteosarcomas typically metastasize
Definition
Lung
Term
What is an Enchodroma, who do they affect and when can they be malignant
Definition

20-40 yrs old

Soap Bubble islands of epiphyseal cartilage left behind

Malignant in:

Olier's Disease-Multifocal Enchondromas

Marfucci's Syndrome- Olier's with Hemangiomas

Term
What are some indicators that a cartilagentous tumor is malignant
Definition

> 1 Cell per lacunae

Necrosis

Mitotic Figures

Term
What are the features of a chondroblastoma and who does it affect
Definition

10-20 yrs old

Epiphyseal tumor with sclerotic margin

Term
Who does Chondosarcoma typically affect
Definition
>50 typically in metaphysis
Term
What patients typically get Giant cell bone tumor and what should you know about it
Definition

20-50

Transform, recur in epiphyseal

Term
What's is Ewing's Sarcoma
Definition

Primative Neuroectodermal Tumor is diaphysis

Caused by 11;22 Translocation

Term
What is Jaffe-Campanaci Syndrome?
Definition
Cafe Au Lait Spots and Multiple Fibromas
Term
Most common sight of bone tumors in the body
Definition
Distal Femur and Proximal Tibia
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