Term
|
Definition
Icosahedral
Enveloped dsDNA
VP16 in Tegument
Ul and Us Dna segments: for Recobination and Cicularization
Glycoproteins: gB, gD, gH for cell entry |
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|
Term
| What is the replication sequence of HSV |
|
Definition
Heparin Sulfate binding
Fusion
Nucleus Injection
Immeadiate-Early: VP16 Enhances
Early: Replication Machinery, Degradation inhibition
Late: Capsid-> Tranported back to Nucleus
Enveloping from Nuclear membrane
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|
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Term
| What sex is more likely to be HSV Assymptomatic |
|
Definition
|
|
Term
| Can HSV be passed vertically |
|
Definition
| Yes by birth or Ascending infection |
|
|
Term
| What is the Pathogenesis of HSV |
|
Definition
Mucousal Entry
Vesicular Lesions
Cowdry's Type A Inclusions
Neuronal Spread
Latency: LAT-> Antisense to IE Gene, May block Apoptosis
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|
|
Term
| How is HSV diagnosed and treated |
|
Definition
Micro of lesion: Giant cells, Cowdry's Type A
Rx: Acyclovir |
|
|
Term
| What is the pathogensis of Varicella Zoster Virus |
|
Definition
Respiratory
Viremia
Reticuloendothelial Organs
Dermal Vesiculopustular Rash
Latency |
|
|
Term
| What is the Presentation of Varicella |
|
Definition
14 day incubation
Fever+Generalized Macropapular rash
Thrombocytopenia
More severe in adults |
|
|
Term
| What virus is easier to culture HSV or VZV |
|
Definition
|
|
Term
| What is the presentation of Herpes Zoster |
|
Definition
Pain
1 or more dermatomes
Postherpeutic Neuralgia |
|
|
Term
| What are some specific characteristics of Pox virus |
|
Definition
Most complex dsDNA(linear with fused ends)
Cytoplam replication(carries Enverything)
Guarneri Bodies |
|
|
Term
| What is the pathogenesis of Small Pox |
|
Definition
Respiratory
Lymphatics
Rash small vessel Hemorrhage
15-40% Mortality |
|
|
Term
| What is the presentation of Moluscum Contagioisum |
|
Definition
Contact with lesion
2-8 wk incubation
Wart-like growth with Caseous Plug |
|
|
Term
How do you diagnosis poxvirus
|
|
Definition
Eosinophillic Inclusions Guarneri
|
|
|
Term
| What is the characteristic lesion under microscopy for HSV |
|
Definition
|
|
Term
| What glycoprotein of HSV can differentiate between type II and Type I and which is necessary for viral penetration? |
|
Definition
Typing: gC
Penetration: gB |
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