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Ontogeny of Neural Cell Types
Medical School Devo
34
Other
Graduate
09/18/2011

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Term
What does neural tube neuroectoderm give rise too?
Definition
CNS cell types
Retina
Posterior Pituitary
Term
What does Neural Crest give rise too?
Definition
PNS cell types
Soft meninges
Andrenal Medulla
Term
What do Cranial neural crest give rise too?
Definition
Cranial primary sensory ganglia
cranial parasympathetic ganglia
cranial nerve glia (except CN2)
cranial soft meninges
Term
What do Truncal Neural Crest cells give rise too?
Definition
DRG
peripheral nerve glia
sympathetic ganglia
andrenal chromaffin cells
Term
What gives rise to parasympathetic (enteric) ganglia?
Definition
Circumpharyngeal/Vagal and Sacral neural crest cells
Term
What determines the final fate of neural crest cells?
Definition
The signalling they recieve during migration
Term
What determines the final fate of neural crest cells?
Definition
The signalling they recieve during migration
Term
What neural crest cells take a dorsalateral migration path?
Definition
melanocytes
Term
What neural crest cells take a ventral migration path?
Definition
DRG cell types
Term
What neural crest cells take a ventrolateral migration path?
Definition
sympathodrenal
Term
sympathoadrenal neural crest cells can be differentiated into two cells. What are these cells and what signals differentiate them?
Definition
Postganglionic sympathetic neurons:
-nerve growth factor

adrenal chromaffin cells
-glucocorticoids
Term
GDNF (glia derived neurotrophic factor) signals the neural crest into differentiation of what cells?
Definition
Parasympathetic plexuses of the gut
Term
Dura mater originates from what cells?
Definition
Mesoderm
Term
Pia and Arachnoid mater originate from what cells?
Definition
Neural crest cells
Term
What are the myelin forming cells of the CNS?
Definition
Oligiodendrogial cells
Term
What are the myelin forming cells of the PNS?
Definition
Schwann Cells
Term
What are the post-mitotic cells of the CNS?
Definition
Neurons, Astrocytes, Oligodendrocytes, and microglia
Term
Neuroblasts give rise to what cells in the CNS?
Definition
Neurons
Term
Glioblasts give rise to what cells in the CNS?
Definition
Astrocytes and Oligodendrocytes
Term
Mesoderm gives rise to what cells in the CNS?
Definition
Microglia
Term
What comes first? Neurogenesis or gliogenesis?
Definition
Neurogenesis
Term
What are the four functional groups of neurons that develop in cord?
Definition
GSA
GVA
GSE
GVE
Term
In the brainstem, what is the position of the basal and alar plate?
Definition
Basal plate is medial to the alar plate
Term
The developing medulla contains what cranial nerve?
Definition
Hypoglossal (CN 12)
Term
The developing pons contains which cranial nerves?
Definition
4 Trochlear and 6 Abducens
Term
The developing midbrain contains what cranial nerves?
Definition
CN 3
Term
What cells make up the CNS glia?
Definition
astrocyte
oligodendrocyte
microglia
Term
What is the peak time for neuron synthesis?
Definition
second trimester
Term
What is the one glial subtype that developes before neurons? What is the function?
Definition
Radial glia. Create temporary "scaffolding " that allows the neuron to reach its place
Term
What causes the tight junctions to form for the blood brain barrier?
Definition
Astrocytes
Term
What drugs can pass the blood-brain barrier?
Definition
lipophillic or hydrophobic drugs
Term
Completion of myelination of the anterior cerebellum happens in the 20's and grants what type of cognitive function?
Definition
Executive function:
wisdom
insight
judgement
foresight
"maturity"
personality
Term
Where does persistant neural growth occur in adults?
Definition
hippocampus
Term
What are the two neural stem cells?
Definition
lateral walls of lateral ventricles

hippocampus
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