Term
| Forms a complex between Topoisomerase II and DNA |
|
Definition
|
|
Term
Alkylates DNA
Tox: pulmonary fibrosis |
|
Definition
|
|
Term
Fragments DNA
Tox: pulmonary fibrosis |
|
Definition
|
|
Term
Blocks purine synthesis
Metabolized by xanthine oxidase |
|
Definition
|
|
Term
Cross links DNA
Tox: nephro and oto |
|
Definition
|
|
Term
Alkylates DNA (electrophil binds)
Nitrogen mustard |
|
Definition
|
|
Term
| Folic acid analog that inhibits dihydrofolate reductase |
|
Definition
|
|
Term
| Prevents tubulin disassembly |
|
Definition
|
|
Term
Intercalates DNA, produces oxygen free radicals
Tox: cardio |
|
Definition
|
|
Term
| DNA alkylating agents for brain cancer |
|
Definition
|
|
Term
| Prevents tubulin assembly |
|
Definition
| Vincristine and vinblastine |
|
|
Term
| Inhibits thymidylate synthase and decreases nucleotide synthesis |
|
Definition
|
|
Term
Selective estrogen receptor modulator
Blocks estrogen binding to ER + cells |
|
Definition
|
|
Term
| Mechanism similar to antivirals acyclovir and foscarnet |
|
Definition
|
|
Term
| Mechanism similar to fluoroquinolones |
|
Definition
|
|
Term
| Mechanism similar to trimethoprim |
|
Definition
|
|
Term
| Monoclonal antibody against erb-B2 (HER 2) |
|
Definition
|
|
Term
| Free radical induced DNA strand breakage |
|
Definition
| Bleomycin, doxorubicin/danirubicin |
|
|
Term
|
Definition
|
|
Term
| Reversible with leucovorin |
|
Definition
|
|
Term
| Treatment for choriocarcinoma |
|
Definition
| Methotrexate or vincristine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Treatment for testicular cancer |
|
Definition
Etoposide
Bleomycin
Cisplatin |
|
|
Term
| Applied topically for actinic keratosis and basal cell cancer |
|
Definition
|
|
Term
Treatment for childhood tumors
(Wilms Tumor, Ewings Sarcoma, rhabdomyosarcoma) |
|
Definition
|
|
Term
| Inhibits ribonucleotide reductase |
|
Definition
Hydroxyurea
(also increases HbF in sickle cell pts) |
|
|
Term
| Side effect of hemorrhagic cystitis |
|
Definition
|
|
Term
| Antibody against philadelphia chromosome tyrosine kinase |
|
Definition
|
|
Term
| Side effects of prednisone |
|
Definition
immunosuppression
acne
hyperglycemia
cataracts
insomnia
osteoporosis
psychosis
hypertension
cushingoid symptoms |
|
|
Term
| Prevent MTX toxicity with: |
|
Definition
| Leucovorin (folinic acid) |
|
|
Term
| Prevent 5-FU toxicity with: |
|
Definition
|
|
Term
| Use this drug to treat leukemia in a patient who is also being treated for gout |
|
Definition
| 6-TG (not metabolized by xanthine oxidase) |
|
|
Term
| Prevent doxorubicin toxicity with: |
|
Definition
|
|
Term
| Prevent cancer drug-induced hematuria with: |
|
Definition
| Mesna (prevents hemorrhagic cystitis caused by cyclophosphamide) |
|
|
Term
| Treatment of nHL in a patient with long-standing cirrhosis would most likely fail because: |
|
Definition
| Cyclophosphamide must be activated in the liver |
|
|
Term
| Prevent cisplatin/carboplatin nephrotoxicity with: |
|
Definition
|
|
Term
| 3 drugs (2 of which are antineoplastic) that cause pulmonary fibrosis |
|
Definition
Bleomycin
Busulfan
Amiodarone |
|
|
