Term
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Definition
| Interferes with the fx of thymidylate synthase, which is required for synth. of thymidine (cont. infusion); triphosphate metabolite is incoporated into RNA (bolus)... Inhibits dTMP synthesis |
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Term
| Wat helps increase stability of FdUMP-thymidylate synthase inhibition and enhances activity of 5-FU in certain cancers? |
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Definition
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Term
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Definition
| colorectal, breast, esophageal, pancreas, stomach, anal, head and neck cancers |
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Term
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Definition
| Stomatitis, diarrhea, cardiac, rare cerebellar tox (HA, visual distrubances, cerebellar ataxia), some alopecia. Ice chips 30 minutes while recieving bolus 5-FU decreases mucositis. Carciac SE seen by ST-seg elevation |
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Term
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Definition
| Interferes with the fx of thymidylate synthase, which is required for synth. of thymidine (cont. infusion); triphosphate metabolite is incoporated into RNA (bolus)... Inhibits dTMP synthesis |
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Term
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Definition
| colon, rectal, breast cancer |
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Term
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Definition
| Diarrhea, mucositis, hand-food synd, nausea, myelosuppresion. |
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Term
| Capecitabine major side effects (2) |
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Definition
| Significant increases in PT and INR in patients on warfarin (switch to LMWH) and elevated phenytoin levels (2C9 Inhibition) |
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Term
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Definition
| Inhibits DNA polymerase and the triphosphate form may incorporate into DNA resulting in chain termination. |
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Term
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Definition
| Acute Leukemias and some lymphomas |
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Term
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Definition
| Myelosuppression, cereballar syndrome (nystagmus, dysarthria, ataxia) and eye irritation requiring ATC steroid eye drop administration. REQUIRES RENAL DOSAGE ADJUSTMENT |
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Term
| Gemcitabine MOA (question on p 1455, doesnt make sense) |
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Definition
| Inhibits DNA polymerase and ribonucleotide reductase, |
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Term
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Definition
| Pancreas, breast, lung, ovary, lung, lymphomas. |
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Term
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Definition
| myelosuppression, flu-likle syndrome, fevers in first 24 hours after admin, rash that appears 48-72 hours after admin, and hemolytic uremic syndrome (life threatening) |
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Term
| What needs to be done for a fever 7-10 days after admin of Gemcitabine |
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Definition
| Tx with broad spec antibx becasue its more than likely febrile neutropenia |
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Term
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Definition
| Causes hypomethylation of the DNA, which normalizes the function of genes that control cell differentiation, promoting normal cell maturation |
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Term
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Definition
| Myelodysplastic syndromes (preleukemia) |
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Term
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Definition
| MSP, renal tubular acidosis, renal dysfx, injection site reactions |
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Term
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Definition
| Incorporated into DNA and inhibits DNA methyltransferase, causing hypomethylation of DNA |
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Term
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Definition
| MSP, constipation, edema, HA, nausea |
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Term
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Definition
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Term
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Definition
| Inhibition of DNA snthesis and cell death as it accumulates as the 5' triphosphate form in leukemic blasts |
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Term
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Definition
| T-cell acute lymphoblastic leukemia and lymphoma after two other chemo regimens have been tried |
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Term
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Definition
| Inhibits purine synthesis. |
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Term
| What enzyme is subject to genetic polymorphisms and can cause severe myelosuppression? |
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Definition
| Thiopurine S-methyl Transferase (TPMT) |
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Term
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Definition
| Acutye lymphocytic leukemia and chronic myelogenous leukemia |
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Term
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Definition
| myelosuppresion, mild nausea, skin rash, cholestasis. |
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Term
| What medication do you have to watch out for when giving 6-MP? |
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Definition
| Allopurinol, must dec. dose by 66-75% because it blocks metabolism of 6-MP |
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Term
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Definition
| Inhibits purine synthesis |
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Term
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Definition
| Acute + Chronic myelogenous leukemia |
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Term
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Definition
| Myelosuppression, mild nausea, cholestasis, rare veno-occlusive disease |
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Term
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Definition
| Interferes with DNA polymerase to cause chain termination and inhibits transcription by incorporation into RNA. |
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Term
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Definition
| chronic lymphocytic leukemia, some lymphoas, and refractory acute myelogenous leukemia |
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Term
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Definition
| myelosuppression and immunosupression. Mild nausea and vomiting and diarrhea. Rare interstitial pneumonitis. |
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