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Oncology Drugs
DAD IV TEST 5
41
Pharmacology
Graduate
04/27/2012

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Cards

Term
Which drugs are monoclonal antibodies?
Definition
Trastuzumab (Herceptin)
Cetuximab (Erbitux)
Term
How does Trastuzumab (Herceptin) work?
What does it primarily treat?
Definition
HER 2 receptor
Metastatic Breast Cancer
Term
How does Cetuximab (Erbitux) work?
What 2 caners does it treat?
Definition
HER 1 receptor
Advanced Squamous Cell Carcinoma (head and neck)
Colorectal Cancer
Term
Which drugs are the tyrosine kinase inhibitors?
Definition
Drugs ending in "nib" + Temsirolimus
Term
What does Imatinib (Gleevec) treat?
Definition
Chronic Mylogenous Leukemia (CML)
GIST (Gastrointestinal Stromal Tumor)
Term
What is Dasatinib used for?
Definition
In case of Gleevec Resistance
Term
How do Gefitinib and Erlotinib work?
Definition
Inhibit EGF receptor
Used for NSCLC, but not 1st choice
Term
How does Sorafinib work?
Definition
PDGF, VEGF, Kit, Raf
(alternative to Sunitinib)
Term
How does Sunitiib work?
Definition
PDGF, VEGF, SCF
GIST + REC > Highly Vascularized
Term
How does Lapatinib work?
Definition
HER 2/ ErbB-2
Breast Cancer
Term
How does Temsirolimus work?
Definition
Esterified rapamycin
Advanced renal cell carcinoma
Term
What are the Angiogenesis Inhibitors?
Definition
Avastin (bvacizumab)- used for colorectal cancer
Term
What are the DNA demethylating agents?
Definition
Decitabine- many leukemias + carcinomas
Term
What are the Proteasome Inhibitors?
Definition
Bortezomib (Velcade)
Vorinostat
Term
What is Bortezomib used for?
Definition
Multiple myelomas (bone marrow)
Term
What is Vorinostat used for?
Definition
Cutaneous T Cell Lymphoma
Term
What drugs use Passive Immunization?
Definition
Rituximab (Rituxan)
Irbritumomab (Zevalin)
Gemtuzumab
Term
How does Rituximab work?
What is it used for?
Definition
against CD20 antigen
treats NHL
Treats RA along with Methotrexate
Term
What is Ibritumomab used for and how does it work?
Definition
against CD20
treats NHL
Term
How does Gemtuzumab work and what is it used for?
Definition
against CD33 antigen
AML ( acute mylogenous leukemia)
Term
What all drug classes are antineoplastic agents- alkylating agents?
Definition
Nitrogen Mustards
Thiotepa
Busulfan
Organoplatinum Compounds
Nitrosoureas
Procarbazine, Dacarbazine, & Temozolomide
Altretamine
Term
What drugs are Nitrogen Mustards?
Definition
Mechloretharine
Chlorambucil
Melphalan
Bendamustine (Treanda)
Cyclophosphamide
Ifosfamide
Term
How does Mechoretharine work?
Definition
dialkylator
Very potent
Used for HL (given IV)
Term
What is the antidote for Mechloretharine?
Definition
Thiosulfate- reacts with electrophillic sites on mustard causing increase in H20 solubility of compound causing elimination
Term
Chlorambucil?
Definition
Oral
HL
Chronic Lymphocytic Leukemia
Term
Melphalan?
Definition
Oral
Multiple Myeloma
Breast- Ovarian Cancer
Bone Marrow Transplant
Term
Bendamustine?
Definition
IV
NHL
Term
Cyclophosphamide
Definition
Oral and IV
widely used (breast cancer)
Term
Ifosfamide
Definition
IV
widely used
causes neuro/kidney/ bladder toxicity
Term
What is Thiotepa used for?
Definition
bladder, ovarian, and breast cancers
monoalkylates
Term
What is Busulfan used for?
Definition
Refractory leukemias
bone marrow transplants
Term
What are the organoplatinum compounds?
Definition
ending in "platin"
Term
What is the dose limiting toxicity of organoplatinum compounds?
Definition
nephro/ neuro toxicity
Term
What are the nitrosoureas?
Definition
Carmustine
Lomustine
Streptozocin
Term
Carmustine?
Definition
IV
HL and NHL
Cross linking
Term
Lomustine
Definition
Oral
HL only
Term
Streptozosin
Definition
methylates DNA
IV
more water soluble; wont cross BBB
pancreatic/colon
HL
REnal Toxicity- dose limiting
Term
Do Procarbazine, Dacarbazine, and Temozolomide have Cross linking?
Definition
NO
Term
Procarbazine
Definition
Made for an MAOi
Oral
Brain Cancer
HL--> MOPP
broken down by cyp and mao
Myelosuppression
Term
Dacarbazine
Definition
alkylating agent
IV
HL; neuroblastoma
pair in injection site
Term
Temozolamide
Definition
oral
cyp not involved
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