Term
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Definition
ONCOGENE
Associated tumor: CML (BCR-abl)
Gene product: Tyrosine kinase |
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Definition
ONCOGENE
Associated tumor: Burkitt's lymphoma
Gene product: Transcription factor |
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Definition
ONCOGENE
Associated tumor: Follicular & undifferentiated lymphomas (inhibits apoptosis)
Gene product: anti-apoptotic molecule |
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Term
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Definition
ONCOGENE
Associated tumor: Breast, ovarian, and gastric carcinomas
Gene product: tyrosine kinase |
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Definition
ONCOGENE
Associated tumor: colon carcinoma
Gene product: GTPase |
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Term
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Definition
ONCOGENE
Associated tumor: Lung tumor
Gene product: Transcription factor |
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Term
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Definition
ONCOGENE
Associated tumor: neuroblastoma
Gene product: Transcription factor |
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Term
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Definition
ONCOGENE
Associated tumor: MEN IIA & IIB
Gene product: tyrosine kinase |
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Term
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Definition
ONCOGENE
Associated tumor: GIST
Gene product: Cytokine receptor |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 13q
Associated tumor: Retinoblastoma; osteosarcoma
Gene product: Rb gene product blocks G1 --> S phase of the cell cycle |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 17p
Associated tumor: most cancers; Li-Fraumeni syndome
Gene product: blocks G1 --> S phase of cell cycle |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 17q
Associated tumor: Breast & ovarian
Gene product: DNA repair |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 13q
Associated tumor: Breast cancer
Gene product: DNA repair |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 9p
Associated tumor: Melanoma
Gene product: inhibits cell cycle progression (CDK inhibitor) |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 5q
Associated tumor: colorectal cancer (FAP)
Gene product: inhibits beta-catenin signaling |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 11p
Associated tumor: Wilm's tumor
Gene product: transcription factor & may be involved w/ p53 signaling |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 11p
Associated tumor: Wilm's tumor
Gene product: transcription factor & may be involved w/ p53 signaling |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 17q
Associated tumor: Neurofibromatosis 1
Gene product: |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 22q
Associated tumor: neurofibromatosis 2
Gene product: |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 18q
Associated tumor: Pancreatic cancer
Gene product: AKA DPC ("deleted in pancreatic cancer") |
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Term
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Definition
TUMOR SUPPRESSOR GENE
Location: 18q
Associated tumor: Colon cancer
Gene product: DCC= "Deleted in colon cancer" |
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