Term
| Forms a complex between topoisomerase II and DNA |
|
Definition
|
|
Term
| Alkylates DNA, toxicity = pulmonary fibrosis |
|
Definition
|
|
Term
| Fragments DNA, toxicity - pulmonary fibrosis |
|
Definition
|
|
Term
| Blocks purine synthesis, metabolized by Xanthine oxidase |
|
Definition
|
|
Term
| Cross-links DNA, nephrotoxic, ototoxic |
|
Definition
|
|
Term
| Nitrogen mystard, alkylates DNA (electrophile that binds DNA) |
|
Definition
|
|
Term
| Folic acid analog that inhibits dihydrofolate reductase |
|
Definition
|
|
Term
| Prevents tubulin disassembly |
|
Definition
|
|
Term
| Intercalates DNA, produces oxygen free radicals, cardiotoxic |
|
Definition
| Doxorubicin, Daunorubicin |
|
|
Term
| DNA alkylating agents used in brain cancer |
|
Definition
|
|
Term
| Prevents tubulin assembly |
|
Definition
| vinca alkaloids: vincristine, vinblastine |
|
|
Term
| Inhibits thymidylate synthase |
|
Definition
|
|
Term
| SERM- blocks estrogen binding to ER + cells |
|
Definition
|
|
Term
| Mechanism similar to antivirals acyclovir/foscarnet |
|
Definition
Cytarabine
(--| DNA polymerase) |
|
|
Term
| Mechanism similar to fluoroquinolones |
|
Definition
Etoposide
(--| topoisomerase) |
|
|
Term
| Mechanism similar to trimethoprim |
|
Definition
|
|
Term
| Monoclonal Ab against HER-2 (erb B2) |
|
Definition
|
|
Term
| Free radical induced DNA strand breakage |
|
Definition
| Doxorubicin, Daunorubicin; Bleomycin |
|
|
Term
| Inhibitor of PRPP synthetase |
|
Definition
|
|
Term
| Reversible with leucovorin |
|
Definition
|
|
Term
Used to reverse
- MTX toxicity
- 5-FU toxicity
- Cyclophosphamide (hemorrhagic cystitis)
- Doxo/Daunorubicin (Cardiotoxicity)
- Cisplatin (nephrotoxicity) |
|
Definition
1. Leucovorin
2. Thymidine
3. Mesna
4. Dexrazoxane
5. Amifostine |
|
|
Term
| Treatment for choriocarcinoma |
|
Definition
| MTX, vincristine, vinblastine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Treatment for testicular cancer |
|
Definition
Etoposide
Bleomycin
Cisplatin
(Erradicate Ball Cancer) |
|
|
Term
| Applied topically for actinic keratosis and basal cell cancers |
|
Definition
|
|
Term
| Treatment for childhood tumors (and name them!) |
|
Definition
Dactinomycin
(Ewing's, Rhabdomyosarcoma, Wilm's tumor) |
|
|
Term
| Inhibits ribonucleotide reductase |
|
Definition
|
|
Term
| SE of hemorrhagic cystitis |
|
Definition
| Cyclophosphamide, Ifosphamide |
|
|
Term
| Antibody against mutated tyrosine kinase |
|
Definition
|
|
Term
| Treatment to dec MTX toxicity |
|
Definition
|
|
Term
| Treatment to dec 5-FU toxicity |
|
Definition
|
|
Term
| Treatment to dec Cyclophosphamide toxicity |
|
Definition
| Mesna (hemorrhagic cystitis) |
|
|
Term
| Treatment to dec Doxo/Daunorubicin toxicity |
|
Definition
| Dexrazoxane (Cardiotoxicity) |
|
|
Term
| Treatment to dec Cisplatin toxicity |
|
Definition
| Amifostine (nephrotoxicity) |
|
|
