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Old exams
Final Exam
29
Pharmacology
Graduate
11/13/2011

Additional Pharmacology Flashcards

 


 

Cards

Term

Ibuprofen

A: Reversibly inhibits COX

B: Analgesic and antipyritic effects

C: Highly protein bound

D: Chronic use inhibits renal PG production

Definition
All
Term
What TNF drug can be given for JRA if methotrexate and hydroxychloroquine don;t work?
Definition
Etanercept (Embrel)
Term
Aspirin triad includes aspirin intolerance and what other 2 symptoms?
Definition
Asthma & Nasal polyps.
Term

A child overdosed on aspirin what are the treatments?

 

Definition

Alkilization of the urine

Activated charcoal

Term
Chronic use of NSAIDS may result in.
Definition
Acute renal insufficiency
Term
To prevent bleeding problems during surgery, aspirin should be discontinued __ before surgery
Definition
1 week before surgery
Term

Which of the following regarding inflixinab is true?

  1. It is a chimeric monoclonal antibody
  2. It neutralizes TNF α
  3. It is used for RA
  4. Human antichimeric AB can limit it's use
Definition
all of the above
Term

NSAIDS are counter indicated for patients that have

  1. Allergy to sulfonamides
  2. Allergy to NSAIDS
  3. The aspirin triad
  4. Methemoglobinemia
Definition
1, 2, 3
Term

Treatment of osteoarthritis include

  1. Ibuprofen
  2. Ketorolac
  3. Celebrex
Definition
1 and 3
Term

Which of the following statements regarding aspirin are correct?

  1. As an antipyritic it is more effective than tylenol
  2. It is less likely than tylenol to cause GI irritation
  3. The late stage of overdose includes respiratory and metabolic acidosis
  4. NAC is the antidote
Definition
3
Term

The glucocorticoid hormones produce which of the following effects?

  1. Decrease fat deposition
  2. Inhibit release and synthesis of thromboxone and leukotrienes
  3. Increase protein synthesis in most tissue
  4. Lower plasma glucose levels
  5. An increase in the number of WBC
Definition
2
Term

Accepted use for celebrex include

  1. Osteoarthritis
  2. RA
  3. Famelial adenomatious polyps
  4. MS
Definition
1, 2, 3
Term
A patient is treated with a horse derivative Ab, and is experiencing hypersensitivity, what should be used?
Definition
Lymphocyte Immunoglobulin (Atgam)
Term

Renal impairment resulting from chronic NSAID use include

  1. AKI
  2. Intestinal nephritis
  3. papillary necrosis
  4. inhibition of renal PG production
Definition
All
Term
Which hypersensitivity involves the Penias?
Definition
Type 2
Term
In a recent study, short term use of recombinant __ reduced the risk of serious infection in CGD patients
Definition
Interferon gamma (actimmune)
Term

Which of the following are steroids not used for?

  1. RA
  2. eczima
  3. conjunctivitis
  4. glomerularnephritis
  5. lupus
Definition
4
Term

Signs seen in children OD on ASA

  1. Hyperthermia
  2. respiratory & metabolic acidosis at late stage
  3. Tinnitus
  4. respiratory alkilosis during early stage
Definition
all
Term

long term administration of Dexamethasone would include all except

  1. Osteoporosis
  2. Hypoglycemia
  3. Peptic ulcer
  4. Cataracts
  5. Adrenal cortical suppression
Definition
2
Term
how should a patient with a goiter and normal T3 and T4 be treated
Definition
subtotal thyroidectamy and T4
Term
administration of lugol's solution will result in
Definition
decreased T4 and T3 in the blood
Term
Alternating therapy should not be done to treat a patient with
Definition
Addison's disease
Term
The principle MOA of fosamax is to
Definition
inhibit osteoclast mediated bone resorption
Term

Which antiinflamatory steroid should not be given IV?

 

Definition
prednisone
Term
Which drug can causes TB?
Definition
Etanercept (embrel)
Term
glucocorticoid produces what effect
Definition
inhibit synthesis and release of thromboxone and leukotrienes
Term
a high 17-OH and cortisol in the urine means
Definition
adrenal insufficiency
Term
synthetic antiinflammatory steroids can induce synthesis of lipocortisin which decreases synthesis of proinflammatory
Definition
PG
Term
Calcitriol, the active form of vit D can treat osteoporosis because it
Definition
raises serum Ca, and lowers PTH
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