Term
| How are HSV, VZV, and Variola spread? |
|
Definition
HSV: direct contact
VZV: respiratory route
variola: respiratory or contact |
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|
Term
| Cowdry's Type A Acidophilic intranuclear inclusion bodies |
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Definition
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Term
|
Definition
HSV
see multinucleate giant cells |
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Term
| Where does the HSV replicate? |
|
Definition
|
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Term
| What is the immune response against HSV? |
|
Definition
ABs against glycoproteins to neutralize/limit the spread of EC virus
CMI: essential for controlling & resolving the infection |
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Term
| mutlinucleate giant cells |
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Definition
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Term
| What is the pathogenesis of VZV? |
|
Definition
replication in respiratory tract
viremia: blood & lymph to reticuloendothelial cells
skin lesions on entire body: dermal vesciulopapular rash, develops in successive crops
becomes latent in DR or CN ganglia |
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|
Term
|
Definition
| 1st herpes episode: acyclovir (oral or topical) |
|
|
Term
| What is the incubation period of VZV? |
|
Definition
|
|
Term
|
Definition
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|
Term
| successive crops with lesions in all different stages |
|
Definition
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|
Term
| unilateral lesions in a dermatome |
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Definition
|
|
Term
| postherpetic neuralgia (chronic pain syndrome) |
|
Definition
| can develop from herpes zoster |
|
|
Term
|
Definition
vaccine: live, attenuated
adults/immunocomp: acyclovir |
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Term
| What is the largest, most complex dsDNA virus? |
|
Definition
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|
Term
|
Definition
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|
Term
| What is special about the variola virus compared to other DNA viruses? |
|
Definition
| It replicates in the cytoplasm instead of the nucleus |
|
|
Term
| What are the 2 variola viruses that infect humans? |
|
Definition
orthopox virus (small pox)
molluscipox vireus (molluscum contagiousum) |
|
|
Term
| wart-like growth in clusters |
|
Definition
|
|
Term
|
Definition
| orthopox virus (small pox) |
|
|
Term
| rash starts on face/extremities and spreads inward |
|
Definition
|
|
Term
| Which human virus of variola can lead to death? |
|
Definition
orthopoxvirus: can lead to death
molluscipoxvirus: benign/self-limiting |
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Term
|
Definition
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|
Term
|
Definition
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|
Term
| How is measles transmitted? |
|
Definition
respiratory droplets
contagious 1-2 days before and up to 4 days after the rash
90% attack rate, 100% symptomatic |
|
|
Term
| What are the virulence factors of measles? |
|
Definition
HN: viral attachment
F: fusion of cells/viral entry
M: inside viral envelope; important in viral assembly |
|
|
Term
| cough, coryza, conjuctivitis, fever, Kaplik's spots |
|
Definition
|
|
Term
| What are some complications of measles? |
|
Definition
bacterial superinfection
post-infectious meningo-encephalitis
SSPE
progressive infectious encephalitis
giant cell PNA w/rash |
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Term
|
Definition
|
|
Term
| What is the clinical presentation of Rubeola Virus? |
|
Definition
| Cough, Coryza, Conjuctivitis, Kalik's spots, maculopapular rash that lasts for 5 days |
|
|
Term
| cough, coryza, conjuctivitis, kaplik's spots, maculopap rash |
|
Definition
|
|
Term
| How is Rubeola Virus spread? |
|
Definition
respiratory droplets
contagious 1-2 days before and up to 4 days after rash
peaks in winter & spring |
|
|
Term
| Explain the pathogenesis of Rubeola Virus |
|
Definition
1. HN: viral attachment
2. F: fusion of cells/viral entry
3. M: important in viral assembly inside envelope
4. 7-21 day incubation
5. local replication in respiratory epithelium
6. lymph spread
7. viremia
5. systemic infection
6. immune response/maculopap rash
7. complications: PNA, post-infectious encephalitis, subacute sclerosing panencephalopathy |
|
|
Term
| What virus does not replicate in the respiratory epithelium? |
|
Definition
|
|
Term
| What are some complications of Rubeola Virus? |
|
Definition
bact. superinfection i.e. PNA
post-infectious meningo-encephalitis
SSPE caused by defective virus assembly
progressive infectous enceph (2-10yrs after primary infection)
giant cell PNA w/rash |
|
|
Term
| When is the MMR vaccine administered? |
|
Definition
| 12-15 months and a booster during elementary school |
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|
Term
| What age group is most affected by Parvovirus B19? |
|
Definition
|
|
Term
| How is parvovirus B19 spread? |
|
Definition
| resp secretions and parenteral transmission |
|
|
Term
| What virus replicates in mitotically active cells of erythyroid origin? |
|
Definition
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|
Term
|
Definition
|
|
Term
| What are the 2 phases in fifth disease? |
|
Definition
1. flu-like Sxs
2. slapped-cheek rash, arthralgias |
|
|
Term
| Who is at risk for complications from parvovirus B19? |
|
Definition
chronic anemia: risk for aplastic crisis
seronegative women: at risk for fetal loss
immunocomp: progressive BM suppression |
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Term
|
Definition
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|
Term
|
Definition
| saliva and respiratory aerosols |
|
|
Term
| In what age group is Roseola most common? |
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Definition
|
|
Term
| What is the clinical presentation of Roseola (Human Herpesvirus-6)? |
|
Definition
| high fever, maculopapular rash seen in AIDS patients and children <4 |
|
|
Term
| syncytia formation/multinucleate giant cells |
|
Definition
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Term
|
Definition
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