Term
| Etiology of dentigerous (follicular) cyst |
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Definition
Developmental odontogenic cyst associated w/ crown of unerupted tooth
Epithelium from reduce enamel epithelium (enamel organ rests)
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Term
| Demographics of dentigerous (follicular) cyst |
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Definition
| Teens-20s, crown of impacted tooth, most common developmental odontogenic cyst, second most common odontogenic cyst |
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Term
| Clinical features of dentigerous cyst |
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Definition
| Attached at CEJ and covers crown of unerupted tooth, any unerupted tooh (esp third molars, maxillary canines), asympatomatic unless secondarily infected, delayed eruption of involved tooth +/- neighboring tooth |
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Term
| Radiographics of dentigerous cyst |
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Definition
| Radiolucency associated with crown of unerupted tooth, dentigerous cyst (>4 mm) vs. enlarged follicle (<4 mm), unilocular, root development complete |
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Term
| Histology of dentigerous cyst |
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Definition
| Fibrous to fibromyxomatous (more ground substance; less collagen) CT- normal dental follicle wall, 2-3 layers of non-keratinizing epithelial lining, +/- inflammation |
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Term
| Treatment for dentigerous cyst |
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Definition
| Enucleation +/- extraction of associated tooth |
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Term
| Prognosis of dentigerous cyst without treatment |
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Definition
| Continues to increase in size, significant bone destruction, root resorption of neighboring teeth, secondary infection if communication w/ oral cavity; rarely transforms into SCCA or ameloblastoma |
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Term
| Dentigerous cyst variant: eruption cyst |
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Definition
| Looks like mucocele but we don't get mucoceles on alveolar process; = soft tissue version, erupting tooth underneath surface as fluid filled soft tissue bump, blood in cyst may give bluish appearance |
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Term
| Treatment for eruption cyst |
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Definition
| None, usually resolves spontaneously; if not excise roof of cyst |
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Term
| Clinical features of buccal bifurcation cyst/inflammatory buccal cyst |
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Definition
| Cyst on buccal surface aspect of mandibular 1st molar and 2nd, form along furcation area on buccal surface --> tipping tooth, children, uncommon, roots displaced lingually |
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Term
| Etiology of buccal bifurcation cyst |
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Definition
Inflammation related to gingiva/eruption; don't really know
teeth are vital |
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Term
| Histopathology of buccal bifurcation cyst |
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Definition
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Term
| Treatment of buccal bifurcation cyst |
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Definition
| Curettage, tooth preservation |
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Term
| Clinical features of odontogenic keratocyst (OKC)/Keratocystic odontogenic tumor (KOT) |
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Definition
| Uncommon, 10% of odontogenic cysts; aggressive; high incidence of recurrence (30%), found anywhere in jaws, esp. posterior mandible (40% assoc w/ impaction, also not tooth associated); any age; 5% of cases assoc w/ NBCCS |
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Term
| Radiographic features of OKC |
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Definition
| Unilocular (small) or multilocular (large), smooth, corticated borders (slow growing), tooth displacement > resorption |
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Term
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Definition
Highly characteristic; epi lining, luminal (lining the cyst cavity) cells = parakeratinized giving cheese appearance
Parakeratin matures and falls off into the hole; basal cell layer: palisaded |
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Term
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Definition
| Aggressive usually, recurrent so need to keep eye on patient, (more aggressive for max. regions), chemical cautery, decompression/marsupialization and late surgery vs. resection; maybe extraction of tooth |
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Term
| Nevoid Basal cell carcinoma syndrome (=Gorlin Goltz syndrome) Major criteria: |
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Definition
Odontogenic keratocyst(s) (multiple); multiple basal cell carcinomas; calcified falx cerebri; palmar/plantar pits (three or more) first degree relative, bifid ribs, >90% of affected white patients dev BCCs, 40% of affected black pts develop BCCs
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Term
| Nevoid basal cell carcinoma syndrome Minor Criteria: |
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Definition
| Childhood medulloblastoma (CNS tumors), macrocephaly, cleft lip/palate, polydactyly (extra fingers/toes), ovarian/cardiac fibromas, ocular anomalies, other CNS tumors |
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Term
| ETiology of nevoid basal cell carcinoma syndrome |
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Definition
| Mutation of Patched-1 (PTCH) gene which is tumor suppressor gene, Autosomal dominant 75% inherit condition from parent, 25% de novo mutation |
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Term
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Definition
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Term
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Definition
| Two major and one minor criteria, one major and three minor criteria; VS. molecular genetic testing identifies muttaion about 80% of patients |
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Term
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Definition
| Cyst in which epithelium matures to parakeratotic surface, locally aggressive, can be very destructive, tendency to recur after tx, unilocular or multilocular; can be associated w/ impacted tooth, erupted tooth, jaw |
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Term
| Characteristics of orthokeratinizing odontogenic cyst |
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Definition
| Aggressive, low recurrence rate, orthokeratinizing |
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Term
| Etiology of lateral periodontal cyst |
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Definition
| Non-inflammatory developmental odontogenic cyst, dental lamina remnants (rests of Serres) |
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Term
| Clinical features of lateral periodontal cyst |
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Definition
| Asymptomatic radiolucency, in bone, adjacent to root of vital tooth, mandibular/PM area, canine area; maxillary lateral incisor area, wide age range |
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Term
| Radiographic features of lateral periodontal cyst |
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Definition
| Unilocular radiolucency, round-tear drop shaped, mid-root area, don't get very large |
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Term
| Histopathology of lateral periodontal cyst |
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Definition
| Characteristic**makes diagnosis, focal plaque-like thickening, glycogen-rich clear cells |
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Term
| Treatment of lateral periodontal cyst |
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Definition
| Surgical excision of cyst only, need to biopsy |
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Term
| Lateral periodontal cyst varient: botryoid odontogenic cyst etiology |
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Definition
| Multilocular, histopathology identical to lateral periodontal cyst |
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Term
| Lateral periodontal cyst variant: gingival cyst of the adult clinically |
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Definition
| soft tissue of LPC, no bone involvement, mandibular/PM, canine areas, should be able to make clinical Dx if classic appearance/location |
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Term
| Gingival cysts of newborns etiology |
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Definition
| Small superficial keratin-filled cysts on alveolar mucosa of infants, very common, developmental odontogenic vs. non-odontogenic |
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Term
| Clinical appearance of gingival cysts of newborns |
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Definition
| Single-multiple, off-white nodules, ~2mm diameter; Bohn's nodules = gingival alveolar bone; epstein's pearls = palatal midline |
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Term
| Glandular odontogenic cyst clinical |
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Definition
| Rare dev cyst of jaws, esp. anterior mandible, often crosses midline, +/- extensive destruction, impacted, erupted or no tooth association |
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Term
| Radiographic of glandular odontogenic cyst |
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Definition
| Radiolucent, esp. multiloculated, esp. anterior mandible, often crosses midline, border varies |
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Term
| Histopathology of glandular odontogenic cyst |
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Definition
| Cyst, non-keratinized epithelial lining, mucous cells +/- cilia, similarity to mucoepidermoid carcinoma (malignant salivary gland tumors), misdiagnosis a real possibility! |
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Term
| Treatment of glandular odontogenic cyst |
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Definition
| Locally aggressive, high recurrence (+25%), removal of block of involved bone, potential for misdiagnosis |
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Term
| Calcifying odontogenic cyst (=Gorlin cyst, "Calcifying cyst odontogenic tumor") etiology |
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Definition
| Rests of dental lamina (serres) |
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Term
| Clinical features of calcifying odontogenic cyst |
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Definition
| Uncommon, asymptomatic, esp anterior jaws, max>mand, esp <50 yo; sometimes assoc with impacted teeth |
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Term
| Radiographic of calcifying odontogenic cyst |
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Definition
| Unilocular radiolucency, well-defined margins, +/- scattered radiopacities ("calcifying...") |
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Term
| Histopathology of calcifying odontogenic cyst |
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Definition
| Cyst, "ghost cells" (keratinized epithelium) from calcifications within cyst lining, have to have a lot of them to see on radiograph; +/- calcification |
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Term
| Treatment of calcifying odontogenic cyst |
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Definition
| Slightly more aggresive than plain "cysts," slightly increased recurrence rate, generally, conservative removal recommended |
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Term
| Carcinoma developing in an odontogenic cyst clinical |
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Definition
| Very rare, Mandible>maxilla, paresthesia, +/- pain/swelling; teeth look like they are sitting in air |
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Term
| Carcinoma dev in odontogenic cyst radiographic |
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Definition
| Radiolucency; ill-defined, irregular margins |
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Term
| Histopathology of carcinoma dev in odontogenic cyst |
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Definition
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Term
| Treatment of carcinoma developing in odontogenic cyst |
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Definition
| Aggressive surgical resection +/- neck dissection |
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Term
| Prognosis of carcinoma developing in an odontogenic cyst |
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Definition
| High % metastases (very quickly to the neck, lung, high recurrence rate); poor prognosis |
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