Term
|
Definition
| Auto immune attack of eyelash melanocytes --> white lashes |
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Term
|
Definition
| staph bleph; albinism; Vog-Koyanagi-Harada syndrome |
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Term
|
Definition
| Vogt-Koyanagi-Harada syndrom |
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Term
|
Definition
| treat the bleph; refer if albinism/VKH present |
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Term
|
Definition
|
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Term
| What are s/sx of vitiligo? |
|
Definition
| usually bilateral eyelid presentation, frequently positive FHx |
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Term
| What age does vitiligo present? |
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Definition
|
|
Term
| What is the cause of vitiligo? |
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Definition
|
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Term
|
Definition
|
|
Term
| What is the occurrence of vitilgo? |
|
Definition
| 1-2% worldwide, more often in dark skinned people |
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Term
|
Definition
determine of FHx;
rule out associated syndromes,
use cosmetic camouflage,
sunscreen,
melanocyte stimulation and skin color blending w/ amino acids |
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Term
| What is the long term tx for vitiligo? |
|
Definition
|
|
Term
| What must be done with vitiligo pts? |
|
Definition
| Referred to dermatologist |
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Term
| What is Vogt Koyanagi Harada Syndrome? |
|
Definition
rare, multisystem disorder.
Common age 20-50 |
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Term
|
Definition
Prodromal phase
Lasts a few days with meningitis, encephalopathy, auditory disturbances |
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Term
|
Definition
| Acute uveitic phase: anterior and posterior uveitis |
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Term
|
Definition
Convalescent phase; first three of the sx below most common
Alopecia, poliosis, vitiligo, fundus lesions, depigmented limbal lesions |
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Term
|
Definition
Chronic-Recurrent phase
smoldering anterior uveitis w/ exacerbations |
|
|
Term
| Three of what four signs must be present to diagnose VKH? |
|
Definition
bilateral chronic anterior uveitis
posterior uveitis
cutaneous lesions
neurological features |
|
|
Term
| What is a severe hallmark sign of VKH? |
|
Definition
| acute serous retinal detachment |
|
|
Term
| Where is sunset glow fundus found? |
|
Definition
|
|
Term
| What is the tx plan for VKH? |
|
Definition
oral steroids
periocular injected steroids
topical steriods for anterior uveitis
If steroids are not sufficient, use immunosuppressive agents cyclosporine or chlorambucil |
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Term
|
Definition
| Ocular Cicatricial Pemphigoid |
|
|
Term
|
Definition
systemic autoimmune inflammatory disease
mucous membrane disorder involving the conjunctiva, often asymmetric |
|
|
Term
| What type of hypersensitivity is OCP? |
|
Definition
|
|
Term
| What is the prevalence of OCP? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is a significant side effect of OCP? |
|
Definition
| bilaterally blindness/visual loss |
|
|
Term
|
Definition
| Blisters form, swell, and burst repeatedly until scars are formed |
|
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Term
|
Definition
| skin and mucous membranes |
|
|
Term
| What can be asymmetric in OCP? |
|
Definition
time of onset
severity
rate of progression |
|
|
Term
| When is conjunctival dx seen in OCP? |
|
Definition
| 75% w/oral involvement; 25% w/ skin lesions |
|
|
Term
| Name some characteristics of OCP |
|
Definition
idiopathic
chronic
progressive
female > male |
|
|
Term
| What is the age of onset for OCP? |
|
Definition
| 6th or 7th decade, often subtle and hard to detect, though early detection crucial for preventing vision loss |
|
|
Term
|
Definition
|
|
Term
|
Definition
Conjunctival scarring and shrinkage
worsens over 3-4 years
continued scarring and shrinkage |
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|
Term
|
Definition
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|
Term
|
Definition
| end stage with corneal scarring and anklyblepharon |
|
|
Term
|
Definition
| fibrous tissue adhering bulbar to palpebral conj |
|
|
Term
|
Definition
| Severe overgrowth of tissue over the cornea? |
|
|
Term
| What is the endstage of OCP? |
|
Definition
|
|
Term
| What are other DDx related to OCP? |
|
Definition
Chemical trauma
radiation injury
other mucous membrane disorders |
|
|
Term
| What % of OCP cases are confirmed with a conjunctival biopsy? |
|
Definition
|
|
Term
| How can OCP cause dry eye? |
|
Definition
| destroys goblet cells and meibomian glands |
|
|
Term
| What is Dapsone used for? |
|
Definition
| Treating the acute inflammatory stage of OCP |
|
|
Term
| What are ocular therapies for OCP? |
|
Definition
treat w/ surgery:
trichiasis, entropion and symblepharon |
|
|
Term
| What is Stevens-Johnson Syndrome? |
|
Definition
| acute but self limiting (non-progressive) inflammation with minor and major variants |
|
|
Term
|
Definition
| skin and maybe a single mucosal membrane affected |
|
|
Term
|
Definition
| Involves skin and two or more mucosal membranes |
|
|
Term
|
Definition
|
|
Term
| What is usually seen with SJS? |
|
Definition
| Systemic toxicity causing malaise, fever, sore throat, HA |
|
|
Term
| What is the mortality rate of SJS? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What % of SJS is seen in children? |
|
Definition
|
|
Term
| Who are more likely to get SJS? |
|
Definition
| men, though no racial predilection |
|
|
Term
| What is the etiology of SJS? |
|
Definition
| Thought to be delayred hypersensitivity response to drugs and epithelial cell antigens |
|
|
Term
| What is common pharmacological cause of SJS reaction? |
|
Definition
sulfonamides***
penicillin, nsaids, etc |
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