Term
|
Definition
| Dz in workers in fluorescent light faqctories & nuclear weapoin industry |
|
|
Term
| pathophysiology of occupational lung disease: |
|
Definition
| inflammation and fibrosis |
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|
Term
| respiratory Sx of occupational lund dz |
|
Definition
| cough, dyspnea, wheezing, clubbing, cyanosis, breath sounds(crackles) |
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Term
| occupational lung dz tests: |
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Definition
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Term
|
Definition
| pulmonary fibrosis caused by inhalation of asbestos |
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|
Term
| asbestos was greatly used from ____ - ____ |
|
Definition
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Term
|
Definition
| 59X to get malignant mesothelioma |
|
|
Term
| dose dependant sx appear __yrs after exposure. |
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Definition
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|
Term
| clinical manifestations of asbestosis: (6) |
|
Definition
1. MOST COMMON: exertional dyspnea
2. nonproductive cough
3. nonspecific chest discomfort
4. clubbing
5. bibasilar crackles: persistent dry
6. cor pulmonale: cyanosis, jug v distension, pedal edema |
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Term
|
Definition
| infiltrates most prominenet at lung bases, shagy heart borders |
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Term
| PFT in asbestosis shows a __________ pattern |
|
Definition
|
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Term
|
Definition
1. medications not effective
2. O2 therapy
3. immunizations; flu, s pneumo
4. prompt antobiotic for infections |
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|
Term
| oldest known occupational Dz |
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Definition
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|
Term
| where does silica come from |
|
Definition
| naturally occuring mineral silicone dioxide, quarts is the most common form; others are sandstone, slat and shale |
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|
Term
| with silicosis there are increased risks for _____________ infections |
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Definition
|
|
Term
| silicosis may be reponsible for the development of ____ primarily in the form of _________ |
|
Definition
| responsible for COPD primarily emphysema |
|
|
Term
| which systemic dz are silicosis pts at risk for developing? |
|
Definition
|
|
Term
| who is at risk for silicosis? |
|
Definition
| miners, construction workers, ceramic workers, tunnel drillers, sandblasters, quarry workers, stone |
|
|
Term
|
Definition
| phagocytosis of material and assoc inflammation lead to destruc of lung parynchema and fibrosis from the continual rebuilding of the tissue from fibroblasts |
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|
Term
| Key sign in pathology study of silicosis: |
|
Definition
| onion skin surrounded by inflammitory cells, dust ladened macrophages, silica crystals in polarized light |
|
|
Term
|
Definition
asymptomatic
exertional dyspnea
PRODUCTIVE COUGH
pleuritic chest pain
fever wieght loss malaise
clubing is UNCOMMON |
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|
Term
| PFT results for silicosis: |
|
Definition
| mixed obstructive/restrictive patterns |
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|
Term
| pt with silicosis should have a ___ test done |
|
Definition
|
|
Term
|
Definition
no tx cures or alters the dz
corticosteroids may be helpful in acute silicosis
supplimental O2
lung txplnt |
|
|
Term
| which occupational lung dz has linear opacities on CXR? |
|
Definition
|
|
Term
| which occupational lung dz has nodular opacities on CXR |
|
Definition
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Term
| if you suspect occupational lung dz and pt has a normal CXR but abnormal PFT the next move is: |
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Definition
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|
Term
| highest potentials for berylliosis are: |
|
Definition
| nuclear power, aerospace, electronic industries |
|
|
Term
| which internal factor plays a a major role in the exposure to beryllium and the develoment of berylliosis? |
|
Definition
| genetic predisposition seems to play a major role |
|
|
Term
| which immune cells are assoc with berylliosis pathophys? |
|
Definition
|
|
Term
| which type of immune rxn is seen in berylliosis: |
|
Definition
| delayed hypersensativity rxn |
|
|
Term
| most comon sx of berylliosis: |
|
Definition
|
|
Term
|
Definition
1. cough
2. chest pain
3. athralgia
4. fatigue
5. weight loss
6. dyspnea sudden onset |
|
|
Term
|
Definition
inspiratory crackles
lymphadenopathy
dermatitis
hepatosplenomegaly |
|
|
Term
| blood test for berylliosis: |
|
Definition
| beryllium lyphocyte proliferation test |
|
|
Term
|
Definition
50% are normal
hilar adenopathy &/or increased interstitial markings |
|
|
Term
|
Definition
| ground glass opacities, parenchymal nodules |
|
|
Term
|
Definition
| obstructive in 40%, restrictive in 20% |
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|
Term
| BAL in berylliosis shows: |
|
Definition
|
|
Term
| berylliosis histiologic studies show |
|
Definition
| noncaseating granulomas on lung bx |
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|
Term
| 2 major Dx criteria for berylliosis: |
|
Definition
1. evidence of sensitization to beryllium: BeLPT, BAL
2. nonnecrotizing granuloma on lung bx |
|
|
Term
|
Definition
no controlled study therapies are avail.
corticosteroids may be benefitial
if corticosteroids fail: methotrexate
O2 therapy
lung txplnt |
|
|
Term
| commonalities in Tx btwn occupational lung dz: |
|
Definition
O2 therapy
corticosteroids may be helpful
no real tx/cure |
|
|
Term
| key words: shaggy heart border |
|
Definition
|
|
Term
| key words:restrictive PFT |
|
Definition
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|
Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
| key words: productive cough |
|
Definition
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|
Term
|
Definition
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|
Term
| key words: genetic predisposition |
|
Definition
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|
Term
| key words: polarized crystals |
|
Definition
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|
Term
| key word: hepatosplenomegaly |
|
Definition
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