Shared Flashcard Set

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OB/GYN
Guest Lecture Compilation
218
Medical
Graduate
09/04/2011

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Cards

Term
What is the transformation of bilaminar disk to trilaminar disc?
Definition
gastrulation
Term
when does gastrulation occur?
Definition
week 3
Term
Where is the ectoderm, mesoderm, and endoderm derived?
Definition
epiblast
Term
where is urogenital ridge derived from
Definition
intermediate plate
Term
when is the embryonic period?
Definition
weeks 4-8
Term
Genetic sex is determined...
Definition
at fertilization
Term
gonadal sex is determined....
Definition
8-11 weeks; determined by influence of the genetic sex on undifferentiated gonad
Term
ducal sex is determined...
Definition
9-12 weeks; determined by the presence or absence of testicular products
Term
genital sex is determined...
Definition
12-20 weeks determined by presence or absence of androgen
Term
where do germ cells originate?
Definition
in the primary ectoderm of the embryo and migrate into the yolk sac
Term
when does the urogenital ridge form?
Definition
week 5
Term
The y-chromosome consists of two very important regions that determine "maleness," which is...
Definition
SRY and TDF (sex determining region of y chromosome, and testis-determining factor)
Term
When do testis develop?
Definition
8th week
Term
what is the key product of sertoli cells of a male during fetal development?
Definition
anti-mullerian hormone
Term
What is the function of Leydig cells in the male during embryo-genesis?
Definition
produce testosterone for differentiation of external genitalia and formation of wolffian ducts
Term
What type of anomalies in the fetus account for highest of all body systems?
Definition
urogenital tract anomalies (10%)
Term
menarche is....
Definition
first period
Term
Is urinary/breat history part of gynecological history?
Definition
yes
Term
GaPbcde what do the subscripts stand for?
Definition
a=how many times they've been pregnant
b=to full term (at least 37 weeks)
c=to pre-term (20 weeks)
d=miscarriages/abortions
e=living children
Term
Analyze G3P1103
Definition
A woman with 2 kids who has had one pre-term delivery, no misscarriages, and is currently pregnant
Term
Bartholin's glands
Definition
Glands on the vagina that is disto-lateral to the vaginal opening
Term
introitus
Definition
entry into the vagina
Term
pouch of douglas is also known as
Definition
the recto-uterine pouch
Term
is the isthmus of the uterine tube fixed or flexible?
Definition
fixed
Term
The right ovary is drained to the....
Definition
inferior vena cava
Term
the left ovary is drained by the
Definition
left renal vein
Term
when is there a heartbeat? when can it be seen on ultrasound? on doppler?
Definition
3-4 weeks; 6-7 weeks; 12 weeks
Term
when is fetal movement first detected?
Definition
14-20 weeks
Term
What time period is the most important for major defects of the fetus?
Definition
first 8 weeks
Term
Number 1 birth defect:
Definition
hypospadias
Term
Does estrogen increase or decrease the risk of clots?
Definition
increases
Term
By what percentage does blood volume increase during pregnancy?
Definition
30%
Term
Pelvic inflammatory disease is defined as....
Definition
generic term for inflammation of uterus, fallopian tubes, and/or ovaries
Term
What is the concern with pelvic inflammatory disease and pregnancy?
Definition
Increased risk of tubal pregnancies
Term
What does TORCH stand for
Definition
toxoplasmosis
other (parvo, EBV, Varicella, Syphilis)
rubella
CMV
hepatitis (B and C) and herpes
Term
How many extra calories must a mother eat per day during pregnancy?
Definition
300
Term
Baby movement is not consistent until...
Definition
26-28 weeks
Term
When is the uterus first measure in pregnant mom?
Definition
14-16 weeks
Term
When is Rho-gam administered?
Definition
28-weeks
Term
When is GBS swab performed?
Definition
35-37 weeks
Term
When do doctors screen of TORCH?
Definition
Don't screen during pregnancy because nothing they can do about it, but be done postnatally only
Term
Toxoplasmosis has an increased risk of infection during which trimester?
Definition
the 3rd; although first trimester infection to fetus is more severe
Term
What is fetal toxoplasmosis infection associated with?
Definition
abortion, prematurity, growth retardation
Term
What are the symptoms of a mother with toxoplasmosis infection?
Definition
Mother only has mild, vague symptoms so prevention is the best method to prevent infection (i.e. don't clean litter box, keep indoor cats inside)
Term
What is the prognosis for an infant infected with CMV?
Definition
poor
Term
What are some of the symptoms associated with a fetus infected with CMV?
Definition
prematurity, lbw, microcephaly, chorioretinitis, thrombotic thrombocytopenic purpura...BLUEBERRY BABY
Term
Where does CMV attack?
Definition
hematopoetic centers of body (spleen, bone marrow) and forms ectopic hematopoetic sites
Term
A mother with a heterophile negative mononucleosis syndrome has...
Definition
CMV
Term
Herpes-1 vs. herpes 2
Definition
1 is mostly upper body (mouth) and 2 is lower body (2) although not set in stone anymore
Term
What preventative measures are given to a mother with herpes infection?
Definition
acyclovir @ 36 weeks regardless of active lesions or not
Term
If there are active lesions of herpes on mother during delivery what must be done?
Definition
c-section
Term
What are the symptoms of a baby infected with herpes during delivery?
Definition
seizures
Term
rubella is also known as...
Definition
german measles
Term
what are some of the symptoms of a fetus infected with rubella virus?
Definition
cataracts, deafness, patent ductus arteriosis
Term
The attack rate of this microbe is low but always results in death of fetus.
Definition
GBS
Term
What is the treatment for GBS
Definition
penicillin
Term
When is the worst time during pregnancy to be infected by parvovirus B-19
Definition
first 20 weeks
Term
During what season is parvovirus most prevalent?
Definition
Winter-spring
Term
Parvovirus has a predilection towards what cells in fetus?
Definition
erythroid progenitor cells
Term
What does parvovirus cause in fetus?
Definition
fetal hydrops (conjestive heart failure) secondary to aplastic anemia
Term
What is defined as a UTI?
Definition
greater than 100,000 pure colonies/cc of urine
Term
What are some of the common microbes that cause UTIs
Definition
E. Coli, proteus mirabilis, GBS, klebsiella pneumoniae
Proteus mirabilis and GBS have no nitrate-->nitrite
Term
Is gonorrhea intracellular or extracellular? Gram-negative or positive?
Definition
Intracellular, gram -, diplococci
Term
What is given to infant at birth to prevent blindness?
Definition
silver nitrate (for chlamydia and gonorrhea)
Term
What is the microbe that causes syphilis?
Definition
treponema pallidum
Term
What test can be done to see if mother is infected with syphilis?
Definition
fluorescent treponemal antibody screen
Term
What is the Jarisch-Herxheimer reaction?
Definition
Occurs after treatment of syphilis (penicillin)...begins 2-8 hours post therapy, gets chills fever because of release of endotoxin
Term
What are some of the symptoms of syphilis infection in utero?
Definition
hydrops, large placenta, hepatosplenomegaly
Term
Infant syphilis infection presentation
Definition
persistant rhinitis, generalized lymphadenopathy, osteochondritis (radiographs reveal alternating densities)
Term
Presentation of child with syphilis
Definition
hitchinson's teeth, intersititial keratitis, 8th nerve damage (hearing)
Term
Trichomonas is present in what vaginal pH
Definition
low (acidic) environment
Term
What is the plan for HIV infected mother during pregnancy?
Definition
Initiate Azt after 1st trimester, do C-section, azt to infant after birth, and no breast feeding
Term
AIDS CD4 level
Definition
less than 200 mm cubed
Term
Because there is a windo between HBsAg dissapearance and HBsAG appearance, ___ is used
Definition
HBcAB
Term
What is the percent loss after implantation?
Definition
30%
Term
What is the percent loss of fertilized oocytes before implantation?
Definition
46%
Term
In each ovulatory cycle, only ____ percent can of normally fertile couples can achive a live birth
Definition
25%
Term
pill has ___percent failure (inluding human error)
Definition
3%
Term
What does estrogen in the pill do?
Definition
stabilizes endometrium (reduces menstrual bleeding)
Term
What is the definition of pregnancy according to WHO?
Definition
Implanted embryo
Term
What is provera? what are some of the complications?
Definition
injected progesterone, exacerbate depression, appetite
Term
Copper t380 IUD vs. Mirena IUD
Definition
1. sterile inflammation, good for 10 years, sperm cannot survive, increased blood loss
2. Progesterone releasing, decreased blood loss, increased risk of ectopic pregnancy
Term
RU-486 works by
Definition
anti-progesterone
Term
Condoms have a ____ percent failure rate
Definition
12%
Term
Doing nothing has a ____ percent failure rate
Definition
30%
Term
What is the leading cause of pregnancy-related deaths (of mother) during the first trimester?
Definition
ectopic pregnancy
Term
What accounts for the increasingly high rate of ectopic pregnancies?
Definition
promiscuity, pelvic inflammatory disease, IUDs, tubal surgeries
Term
What is the worst place to have an ectopic pregnancy? The best?
Definition
corneal (where uterine tube and uterus meets)
fimbrial
Term
If a woman has abdominal pain, always always always do this...
Definition
pregnancy test (abdominal pain is the only sure symptom of ectopic pregnancy, other symptoms will vary)
Term
can you still have a period with ectopic pregnancies?
Definition
yes
Term
What is one of the major problems after delivery of an ectopic fetus?
Definition
bleeding (no contraction of uterus to prevent!)
Term
Of all ectopic pregnancies, ampullary accounts for _____%
Definition
40
Term
Are progesterone levels usually high or low in ectopic pregnancies?
Definition
low (0-15)
Term
What hCG levels are necessary to view ectopic pregnancies with abdominal u/s? vaginal u/s?
Definition
6500
1200-1500
Term
what is a Culdocentesis?
Definition
extraction of recto-uterine pouch fluid.
Term
A Culdocentesis reveals non-clotting blood. What is this indicative of?
Definition
ectopic pregnancy
Term
what is a treatment option for ectopic pregnancy?
Definition
methotrexate (need reliable patient)
this is an abortifacient
Term
what is the definition of abortion?
Definition
delivery of fetus weighing less than or equal to 500 grams or less than 20 weeks gestation
Term
what is a habitual abortion
Definition
3 miscarriages in a row
Term
what is a missed abortion
Definition
fetus died, but no bleeding
Term
what percentage of pregnancies will result in miscarriage in 1st trimester?
Definition
10-15%
Term
what are the 4 most common uterine abnormalities that accounts for miscarriage?
Definition
1. mullerian fusion abnormalities
2. synechiae (intrauterine adhesions)
3. leiomyoma (fibroid, muscle growth)
4. incompetent cervical os (2nd trimester loss)
Term
what is a cerclage?
Definition
stitching to fix an incompetent uterus
Term
What is a luteal phase defect?
Definition
insufficient progesterone support of implantation site
trophoblasts should take over the corpus luteum at apporximately 7 weeks gestation
Term
What are some of the methods of abortion/
Definition
dilation and curttage
pitocin
prostaglandin (contractions)
laminaria (sea-weed stick, expands, cervix dilates and contractions start)
dilation and evacuation
Term
Is DIC a potential complication after an abortion?
Definition
yesh
Term
How common is infertility?
Definition
Affects 10-15% of couples
Term
vaginismus
Definition
normal vaginal opening, but anxiety can clamp vagina together completely
Term
Factors for infertility, (give percentages):
male factor
ovulation factors
uterine/cervical factors
medical factors
unexplained
Definition
30-40%
20%
10-15%
5%
10%
Term
At what blood pressure should worsening HBP be given medication?
Definition
160/100 (DO NOT GIVE ACE INHIBITORS)
Term
When is pre-eclampsia most common?
Definition
after 20 weeks
Term
Morbidity/mortality of fetus/mom with eclamptic mother
Definition
20%
Term
C/s or vaginal delivery with eclampsia?
Definition
vaginal still preferable
Term
what is the antidote of magnesium sulfate
Definition
calcium gluconate
Term
what is the most common cause of 3rd trimester bleeding?
Definition
rupture of membranes (but rule out placental previa, vasa previa, placental abruption
Term
What must be done with placenta previa?
Definition
must have C/S because baby cannot come out before placenta
Term
misoprostol (cytotec)
Definition
help to open cervix for labor, also for uterine to contract after labor bleeding
put in rectum b/c vagina will bleed out
Term
Radiological treatment of severe post-partum bleeding
Definition
uterine artery embolization or ligation with O'leary stitch
Term
what std is associated with inguinal lymhpodenapathY/
Definition
chancroid
Term
painful ulcer
painless ulcer
Definition
chancroid
syphilis
Term
most common STD
Definition
herpes
Term
what STD presents with donovan bodies?
Definition
granuloma inguinale (lymphogranula venereum)
Term
what are some of the microbes (3) that cause purulent, non-gonoccocal urethritis?
Definition
chlamydia
ureaplasma
trich
Term
This STD is many times asymptomatic in females, but symptomatic in males
Definition
gonorhhea
Term
Gonorrhea is a gram____, ____cellular, ____cocci
Definition
negative, intra, diplo
Term
All cervical cancer patients have _____
Definition
HPV
Term
HPV infection is also present in 90% of these types of cancers
Definition
anus
Term
Which serotypes of HPV are most common
Definition
16 and 18
Term
How long does it take for viral clearance of HPV
Definition
24 months
Term
If someone has a monogamous relationship and gets HPV, is this a sign of unfaithfullness?
Definition
NO, hpv can be dormant for many years before it shows up
Term
Can hepatitis B be transmitted sexually?
Definition
yes
Term
By what mechanism does the uterus grow in the first trimester? the second trimester?
Definition
progesterone, estrogen
mechanical distention
Term
What are braxton-hicks contractions
Definition
irregular, painless contractions that are not real contractions of labor
Term
What is the source of progesterone during early pregnancy? Maximum at?
Definition
corpeus luteum; 6-7 weeks
Term
Luteoma
Definition
not a tumor but is very large and releases androgens!
Term
decidual reaction
Definition
patches of tissue on uterus that can cause pre-term bleeding
Term
In which way is the uterus rotated during pregnancy
Definition
dextrorotation (to the right)
Term
Chadwick's sign
Definition
cyanosis of vagina, cervix b/c of estrogen and an early sign of pregnancy!
Term
Vaginal changes during pregnancy
Definition
increased secretions, vascularity, length
Term
what bacteria keeps the vagina at a low pH during pregnancy
Definition
lactobacillus
Term
What is typical of urine contents during pregnancy?
Definition
Increased glucose and AA, thus increasing susceptibility to a UTI
Term
Which side of the pregnant women will the ureters and renal pelvis be dilated?
Definition
right side, b/c of sigmoid colon
Term
the right ovarian artery/vein empties into....
the left empties into...
Definition
aorta, IVC
Renal Artery/vein
Term
Changes during pregnancy:
RPF
GFR
FF (filtration fraction gfr/rpf)
clearance of creatinine
Definition
all increase except FF (rpf increase greater then gfr increase)
Term
renal changes:
BUN and Creatine
uric acid
plasma osmolality
sodium
renin/angiotensin
Definition
decrease
decrease (except in pre-eclampsia)
decrease
increase
increase
Term
Is there hyper or hypo secretion of respiratory fluids in mother?
Definition
hyper (always stuffy)
Term
What happens to the tidal volume of mother? How do the kidneys compensate?
Definition
Increase in tidal volume, causing respiratory alkolosis with metabolic compensation (increased bicarb clearance)
Term
What does the decrease in blood CO2 pressure allow for?
Definition
increased CO2 transfer from fetus to mother
Term
supine hypotension syndrome
Definition
When the mother is in the supine position (laying down), aortic/vena cava becomes compressed and causes hypotension
Term
Besides an increase in tidal volume, what also increases in pregnant mom?
Definition
minute ventilation
Term
how much does cardiac output increase? When is it maximal?
Definition
30-50% (Stroke volume x heart rate)
maximal at 10 weeks gestation
Term
what happens to blood pressure of mom during pregnancy?
Definition
increases at first but will decrease (because of decreased arterial resistance) in 2nd trimester and normal levels by term
Term
What happens to venous blood pressure
Definition
increase in lower extremities only, causing swelling, varicosities, hemorrhoids
Term
Why is there a 10-20% increase in cardiac output immediately after delivery?
Definition
associated with reflex bradycardia
Term
Hematological changes:
hematocrit
wbc
platelets
Definition
decrease ( dilutional effect of maternal plasma volume increase)
increase
decrease a little
Term
How much does the maternal plasma vloume increase?
Definition
50%
Term
What happens to RBC mass of mother?
Definition
increases 18-30%
Term
Changes in mother during pregnancy:
t-wave
murmurs
heart sounds
Definition
flattening
ejection murmur
s3 heard
Term
What is the total requirement of iron during pregnancy? How much per day? Does maternal deficiency lead to reduced stores in the fetus
Definition
1000mg, 60mg, no!
Term
Ptyalism
Definition
can't stand taste of own saliva
softening of gums and epulis gravidarum may also occur (tissue on gums)
Term
What are some of the GI changes during pregnancy?
Definition
slower emptying (increased constipation)
slower emptying of gall bladder (cholestastis of pregnancy)
Term
Colostrum
Definition
initial breast milk
Term
striae gravidarum
why hyperpigmentation?
chloasma
linea nigra
Definition
strech marks
increase MSH
mask of pregnancy
darkening of linea alba
Term
What causes lactation?
Definition
decrease in estrogen and progesterone levels
Term
Growth hormone change during pregnancy?
Definition
decrease
Term
thyroid size?
iodine uptake?
TBG?
Definition
all increase (free portion of T3-4 stays same)
Term
What happens to the beta cells of mother during pregnancy?
Definition
hypertrophy+hyperplasia
Term
Human placental lactogen has what effect on mother
Definition
causes insulin resistance
Term
What type of antibody can be transmitted to fetus via breast milk/cross placenta?
Definition
IgG
Term
What does progesterone do in the hypothalamus regarding fat content?
Definition
resets lipostat, increasing fat storage
Term
What is the major nutrient of fetus, that cannot be endogenously produced?
Definition
glucose
Term
HPL from fetus has what effect on fatty acids in mother?
Definition
increases free fatty acids, causes increase in ketone bodies in mother
Term
When is fetal insulin present?
Definition
@12 weeks
Term
Is the rate of diffusion of fats high or low to placenta?
Definition
low
Term
Explain course of blood flow in fetal circulation.
Definition
NUTRIENT RICH BLOOD
Umbilical vein source of nutrient-rich blood
skips liver via ductus venosus and enters IVC
nutrient rich blood skips right ventricle (foramen ovale) and goes to aorta/carotids
NUTRIENT POOR BLOOD
main source is superior/inferior vena cava, goes through right ventricle
ductus arteriosis allows blood to then enter descending aorta and out hypogastric arteries and go out through umbilical artery!
Term
FHR @ first trimester:
FHR 2nd and 3rd:
Definition
170-180
110-140
Term
Respiratory epithelium and bronchioles don't develop until...
Definition
20 weeks
Term
Amniotic fluid is key for development of what?
Definition
lung
Term
what is the purpose of surfactant?
Definition
decreases surface tension to prevent hyaline membrane disease
Term
what is surfactant derived from?
Definition
lecithin and phophatidylglycerol
Term
what is the lecithin/sphingomyelin ratio
Definition
greater than 2
Term
when does phosphatidylglycerol need to be present?
Definition
in diabetic patients
Term
early decels
variable decels
late decels
Definition
head compression (normal)
cord compression
utero/placenta defect (bad)
Term
what is the difference between fetal hemoglobin and maternal hemoglobin?
Definition
has 2 gamma chains that increases affinity for oxygen..also it is 18gm/dl in fetus (elevated)
decreased affinity to 2,3 BPG
Term
is fetal urine hyper or hypotonic
Definition
hypotonic
Term
what can the fetal kidney do better than adult?
Definition
increased glucose absorption
Term
what causes polyhydramnios?
Definition
if baby does not swallow (up to 450cc/day at term) will account for larger stomach
Term
What is treatment for uterine cancer?
Definition
surgical and may require postoperative radiation therapy
Term
what is the definition of menopause
Definition
cessation of menses for a year
Term
What is common about FSH and LH levels in a woman without a uterus?
Definition
they are elevated
Term
do eggs develop into the antral stage during perimenopause? (5 years prior)
Definition
no
Term
When cycles are 45 days, how long until menopause?
Definition
2 years
Term
Do FSH levels increase or decrease a year before menopause?
Definition
increase, as do estradiol levels
Term
what happens to FSH/LH levels after menopause
Definition
both increase, FSH to 25-30 and LH is more variable
Term
When does menopause begin for....
smokers
undernourished
alcohol
Definition
earlier
earlier
later
Term
Hot flashes caused by the decline of ______ and is always preceded by _______
Definition
estrogen; LH surge
Term
what happens to the pH level in a post menopausal women?
Definition
they increase, increasing the susceptibility to vaginosis
Term
Does menopause cause depression?
Definition
no but it can aggravate it, prozac is a therapy for hot flashes anyways
Term
Roles of estrogen
Definition
reduce risk of CV disease
higher HDL levels
prostacyclin and nitrous production
inhibits oxidation of LDL
supresses osteoclasts
aids in absorption of calcium and Vitamin D
increase number of vitamin D receptors on osteoblasts
Term
loss of estrogen leads to _____osteoclastic activity because the osteoclasts will have a _____response to parathyroid hormone
Definition
increase,increase
Term
Bone mass is dependent on.....
Definition
calcium intake before the age of 19
Term
What is a common vertebral problem in woman over age of 65?
Definition
50% will have vertebral compression fractures
Term
A woman is ____times more likely to have endometriosis if within immediate family and these endometrium (either eutopic or ectopic) is resistant to _______.
Definition
6-7
apoptosis
Term
The _____responsible for shedding endometrium during menses dont' work in patients with endometriosis.
Definition
proteinases
Term
What hormone is responsible for the development and growth of endometriosis?
Definition
estrogen dependent (aromatase activity in the endometrium seen in these patients)
Term
what are some of the changes seen in the macrophages/monocytes of endometriosis patients? NK cells?
Definition
secrete growth factors instead of destruction
overexpression of inhibitory receptors
Term
endometriosis is found in ____% of infertile woman
Definition
20-40%
Term
Endometriosis patients have _____peak estrogen levels
Definition
lower
Term
what is the risk of endometriosis in black woman? asian? mean age of diagnosis?
Definition
lower
higher
25-30
Term
symptoms of endometriosis
Definition
new, progressive, sever pain
pain dull and aching
painful intercourse with deep penetration, worse before menses
Term
endometriomas
Definition
ovarian cysts containing menstrual fluid
Term
what is a treatment option for endometriosis?
Definition
danazol (testosterone derivative)
Term
what is the evil twin of endometriosis?
Definition
adenomyosis
Term
what is adenomyosis
Definition
adeno=gland myo=muscle
Term
where is adenomyosis only found (in what woman)
Definition
women who have had children
Term
what are some of the symptoms of adenomyosis?
Definition
painful and frequent menses
Term
how can you distinguish adenomyosis from endometriosis?
Definition
adenomyosis does not respond to hormonal stimuli, normal age is 40 years, tender and boggy uterus
Term
what is the only treatment for adenomyosis?
Definition
histerectomy
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