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Nutrition and Health
I hate school.
172
Nutrition
Undergraduate 1
04/06/2014

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Cards

Term
Amino Acids
Definition
Building blocks for proteins

Carry C, H, O, N

Has an acid group, amino group, and a unique side (R) group.

20 different kinds: 11 nonessential and 9 essential

11 % of the total protein dietary requirement must be supplied by essential amino acids.

"Typical American diets" supply 50% as essential amino acids.
Term
Functions of Protein
Definition
Crucial to the regulation and maintenance of the body.

Producing vital body structures
Blood clotting
Fluid balance
Contributing to ccid-base balance
Hormone and enzyme production
Visual processes
Transport of many substances in the bloodstream
Cell repair
Immune Function
Glucose formation
Niacin formation (from tryptophan)
Providing Energy
Satiety
Term
Branched-chain Amino Acids
Definition
Side (R) group on these amino acids has a branched shape.

Primary amino acids used by muscles for energy needs

Include leucine, isoleucine, and valine (whey proteins)
Term
Protein Deficiency
Definition
Alcoholism can lead to it.

Body tries to conserve amino acids

Eventually, body progressively slows production of new proteins until proteins are broken down more quickly than they are made

Also, concentration of protein in the bloodstream drops below normal causing excessive fluid build up in surrounding tissues. Edema results.
Term
Estimated Essential Amino Acid Needs for Infants and Children
Definition
Infants and preschool children: 40% of total protein intake (Try breast milk or formula)

Later childhood: 20% of total protein intake (Try cow's milk)
Term
Phenylketonuria (PKU)
Definition
Limits body's ability to metabolize the essential amino acid phenylalanine

Causes activity of the enzyme used in processing phenylalanine to tyrosine is insufficient

Tyrosine becomes an essential amino acid

Phenylalanine levels in the blood can increase to toxicity and cause severe mental retardation
Term
Peptide Bonds
Definition
Link together amino acids to form proteins

Acids, enzymes, and other agents are able to break them.
Term
Protein Synthesis
Definition
Takes place in cytoplasm

Enzymes in nucleus read code on one segment (gene) of one DNA strand and transcribe the information onto mRNA

mRNA travels to the ribosomes

Ribosomes translate instructions to produce a specific protein

Amino acids are added one at a time to the polypeptide chain

tRNA brings specific amino acids to the ribosomes as needed during protein synthesis

Energy input is required to add each amino acid to the chain, making protein synthesis "costly" in terms of calorie use

Once polypeptide chain is complete, it twists and folds into the correct structure.
Term
Polypeptide Length
Definition
Chain of 50-2000+ amino acids bonded together.
Term
Sickle Cell Disease (Sickle Cell Anemia)
Definition
North Americans of African descent are esp. prone to this genetic disease

Causes defects in the amino-acid order of two of the four protein chains of hemoglobin

Red blood cells become a sickle shape and no longer carry oxygen efficently

Health deteriorates, and eventually episodes of severe pain in the bones and joints, abdominal pain, headaches, convulsions, and paralysis may occur
Term
Denaturation of Proteins
Definition
Alteration of a protein's structure by exposure to acid, alkaline, heat, or agitation

Uncoils or otherwise deforms the protein

Usually destroys its ability to function normally

Digestion denatures consumed proteins. Sometimes, this can reduce their tendencies to cause allergic reactions.
Term
All-or-None Principle
Definition
Either all essential amino acids are available or none can be used in protein synthesis

Remaining amino acids are used for energy needs or converted to carbohydrate or fat
Term
Soy and Nut Allergies
Definition
Food allergies occur in 8% of children 4 years of age or younger and 2% of adults.

90% of food allergies are soy, peanuts, tree nuts, wheat, milk, egg, fish, shellfish
Term
Protein Digestion
Definition
Food is cooked: protein is denatured, tough connective tissue is softened, generally easier to chew and swallow

Enzymatic digestion of protein in stomach
Stomach acid denatures proteins
Hormone gastrin regulates release of enzyme pepsin breaks unraveled polypeptide chains into shorter chains of amino acids

Partially digested proteins enter small intestine

Hormone cholecystokinin (CCK) released from intestine walls

CCK travels through the bloodstream to the pancreas. The pancreas releases protein-splitting enzymes, such as trypsin.

Chain sizes reduced to one or two-three amino acids.

Enzymes separate amino acids
Term
Gastrin
Definition
Hormone that controls release of pepsin and strongly stimulates stomach acid production

Triggered by thinking about food or chewing food
Term
Protein Absorption
Definition
Individual and short chains of amino acids in the small intestine are taken up by active transport into the absorptive cells lining the small intestine

Remaining peptide bonds are broken down to yield individual amino acids inside the intestinal cells.

Amino acids travel via the portal vein to the liver.

The liver can severely modify amino acids according to body's needs. Maybe combined into proteins, broken down for energy needs, released into the bloodstream, or converted to nonessential amino acids, glucose, or fat.
Term
Protein Absorption During Infancy
Definition
4-5 months of age: GI tract is somewhat permeable to small proteins, so some whole proteins can be absorbed.

Wait until 6-12 months before introducing commonly allergenic foods (like cow's milk and egg whites)
Term
Proteins Produce Vital Body Structures
Definition
Muscles, connective tissue, mucus, blood-clotting factors, transport proteins in the bloodstream, lipoproteins, enzymes, immune antibodies, some hormones, visual pigments, ans the support structure inside bones are primarily protein.

Excess protein in the diet cannot enhance synthesis, but inadequate consumption can prevent it.
Term
Protein Turnover
Definition
The process by which cells break down old proteins and resynthesize new proteins so that cells will have the proteins it needs to function at that time.

Daily, adults make and degrade ~250g of protein. 65-100g is consumed daily.
Term
Proteins Maintain Fluid Balance
Definition
Normal blood pressure in arteries force blood into capillary beds. Blood fluid moves from capillary beds into extracellular spaces to provide nutrients to cells.

Proteins are too large to move out of capillary beds into the tissues, so they attract the proper amount of fluid back to the blood, partially counteracting the force of blood pressure.
Term
Capillary Bed
Definition
Network of one-cell-thick vessels that create a junction between arterial and venous circulation. It is here that gas and nutrient exchange occurs between body cells and the blood.
Term
Edema
Definition
Buildup of excess fluid in extracellular spaces

May be a symptom of a variety of medical problems, so its cause must be identified.
Term
Proteins Contribute to Acid-Base Balance
Definition
Proteins located in cell membranes pump chemical ions in and out of cells, keeping the blood slightly alkaline.

Some blood proteins are esp. good buffers, maintaining acid-base conditions within a narrow range.
Term
Buffers
Definition
Compounds that cause a solution to resist changes in acid-base conditions
Term
Proteins Form Hormones and Enzymes
Definition
Some hormones like the thyroid hormones are made from only one type of amino acid, tyrosine.

One the other hand, insulin is a hormone composed of 51 amino acids.

Neurotransmitters are often derivatives of amino acids, like dopamine and norepinephrine (both synthesized from tyrosine) and serotonin (synthesized from tryptophan).
Term
Proteins Contribute to Immune Function
Definition
Antibodies are proteins produced by one type of white blood cell and bind foreign proteins in the body.

Low protein status can turn measles into a fatal disease for a malnourished child.
Term
Proteins Provide Energy
Definition
During prolonged exercise
During calorie restriction

The amino group is removed and the remaining carbon skeleton is metabolized for energy needs.

Proteins are a costly source of calories.
Term
Proteins Contibute to Satiety
Definition
Highest feeling of satiety after a meal.
Term
Protein Equilibrium (Protein Balance)
Definition
Protein leaves the body in the urea, hair loss, skin loss, feces, nail loss
Term
Positive Protein Balance
Definition
When body is growing or recovering from an illness or injury

Insuline, growth hormone, and testosterone stimulate positive protein balance
Term
Negative Protein Balance
Definition
Acute illness reduces the desire to eat and causes one to lose more protein than is consumed
Term
RDA for Protein
Definition
.8g per kg of healthy body weight
Higher during pregnancy, growth, infancy

10% of total calories. Experts also suggest 15% or up to 35%.
Term
High Protein Diets
Definition
Likely also a diet high in cholesterol and saturated fat and low in fiber, some vitamins, some minerals, and phytochemicals.

Moderate rather than high protein intake is better for kidney health. Limit protein in early stages of kidney disease because somewhat lessens kidney function.
Term
Protein-Calorie Malnutrition (PCM) or Protein-Energy Malnutrition (PEM)
Definition
A condition resulting from regularly consuming insufficient amounts of calories and protein. Results in body wasting, primarily of lean tissue and an increased susceptibility to infections.
Term
Kwashiorkor
Definition
A disease occurring primarily in young children who have an existing disease and consume a marginal amount of calories and insufficient protein in relation to needs. Infections, edema, poor growth, weakness, and an increased susceptibility to further illness occurs.

Ghana: "the disease that the first child gets when the new child comes". Breastfed to gruels.
Term
Marasmus
Definition
A disease resulting from consuming a grossly insufficient amount of protein and calories

Victims have little or no fat stores, little muscle mass, and poor strength

Death from infections is common
Term
Vitamins
Definition
Compounds needed in small amounts in the diet to help regulate and support chemical reactions and processes in the body

1. Is essential
2. Absence causes health decline. Return improves health.
Term
Fat Soluble Vitamins
Definition
A D E K
Term
Water Soluble Vitamins
Definition
B C

Readily excreted from the body with any excess in urine or stool. Very little is stored. Preserve in foods by light cooking methods, such as stir-frying, steaming, and microwaving.
Term
Megadoses
Definition
Intake of a nutrient beyond estimates of needs to prevent a deficiency or what would be found in a balanced diet; 2 to 10 times human needs is a starting point for such a pharmacological dosage.

Used in treatment of a few vitamin deficiencies.
Term
Quality of Vitamin Sources
Definition
Plant, animal, and laboratory (isolated or synthesized) are the same chemical compounds and generally work equally well.

Vitamin E is much more potent in its natural form han in its synthetic form. Synthetic folic acid (in cereal and flour) is 1.7 times more potent than the natural form.
Term
Storage of Vitamins in the Body
Definition
K is only fat soluble readily excreted from the body. Water soluble are rapidly lost from the body, except for B-6 and B-12, which are more readily stored.

Daily consumption necessary.
Term
Vitamin Toxicity
Definition
Vitamin A is the most frequently observed. Overconsumption of fish oils can cause it.

Vitamin E, niacin, B-6, and C must be consumed 15-100 times human needs to become toxic.

Toxicity usually caused by supplements.
Term
Preservation of Vitamins in Food
Definition
Water-soluble (thiamin, C, folate) can be destroyed with improper storage and excessive cooking.

Heat, light, exposure to the air, cooking in water, and alkalinity destroy vitamins.

Sooner a food is eaten after harvest, the less chance of nutrient loss. Maybe blanch (destroy enzymes that break down vitamins) then freeze if not eaten within a few days.
Term
Aborption of Fat-Soluble Vitamins
Definition
Absorbed with dietary fat.

Travel with dietary fat through bloodstream to body cells. Special carries in the bloodstream help distribute some of these vitamins. Stored mostly in the liver and fatty tissues.

Efficient absorption: 40-90% are absorbed.
Cystic fibrosis inhibits fat absorption and may cause fat-soluble vitamin deficiency.
Weight-loss drugs like Xenical can interfere with fat absorption.
Mineral oil is not absorbed and can carry fat soluble vitamins out of the body.

Unabsorbed fat and vitamins go to the large intestine and are excreted in the feces.
Term
Retinoids
Definition
Preformed vitamin A

Only found in foods of animal origin
Term
Carotenoids
Definition
Provitamin A

Plant pigments contain this.

Beta-carotene, orange-yellow pigment in carrots, is the most potent form of provitamin A.

Lutein and Zeaxanthin.
Term
Vitamin A Functions
Definition
Light-dark vision
Color vision (to a lesser extent)
Retinal: adjust from bright to dim light

Maintains health of the epithelial cells of internal and external surfaces of lungs, intestines, stomach, vagina, urinary tract, eyes, skin, and bladder

Certain immune system cells

Growth, Development, Reproduction

Cardiovascular Disease Prevention - carotenoids' antioxidant capability

Cancer prevention - skin, lung, bladder, breast cancers, prostate gland
Term
Night Blindness
Definition
Early sign of vitamin A deficiency
Inadequate retinol
Cannot quickly readjust from bright to dim light
Term
Vitamin A Deficiency
Definition
Cells that line the cornea of the eye lose ability to produce mucus.

Eye becomes dry and easily scratched by dirt and infected. Infection can cause blindness.

Only accidents case more cases of blindness in the world. Diabetes causes more in N. America.
Term
Mucus
Definition
A thick fluid secreted by many cells throughout the body. It contains a compound that has both carbohydrate and protein parts. It acts as a lubricant and means of protection for cells.

Present in cornea.
Term
Xerophthalmia
Definition
Dry eye: Cause of blindness from vitamin A deficiency. A lack of mucus production by the eye leaves it at a greater risk of damage from surface dirt and bacteria.
Term
Macular Degeneration
Definition
Leading cause of legal blindness among N. American adults over the age of 65.

Macular area of the eye provides the most detailed vision.

Age, smoking, and genetics are risk factors.

Carotenoids lower the risk for developing this and cataracts.
Term
Analog
Definition
A chemical compound that differs slightly from another, usually natural, compound. Analogs generally contain extra or altered chemical groups and may have similar or opposite metabolic effects compared with the native compound.
Term
Vitamin A and Acne Treatment
Definition
Retin-A is made of one analog form of vitamin A (topical treatment): irritates, peels skin. blocks skin bacteria from acne lesions.

Accutane (oral) for serious acne. Regulates development of cells in the skin.
Term
Vitamin A Sources
Definition
Preformed: Liver, fish oils, fortified milk, fortified yogurt, eggs, margarine.

Provitamin: dark green and yellow-orange vegetables and some fruits. Carrots, spinach, greens, winter squash, sweet potatoes, broccoli, mangoes, cantaloupe, peaches, and apricots.
Term
Upper Level of Vitamin A
Definition
High intake of preformed vitamin A can cause fetal malformations and spontaneous abortions.

The skin can turn yellow-orange.
Term
Vitamin D Metabolism
Definition
A cholesterol-like substance in the skin cells is converted to the prohormone vitamin D when exposed to ultraviolet B (UVB) rays.

Liver and kidney cells convert the prohormone into its active hormone form.

Provides about 80%-100% of the "average" individual's vitamin D needs. Affected by skin color, age, time of day, season, and location.
Term
Vitamin D Functions
Definition
Help regulate calcium and bone metabolism

Works with parathyroid hormone (PTH) to closely regulate blood calcium so that the appropriate amounts of it will be supplied to all cells.

Ensures normal development of some cells (skin, colon, prostate, ovary, and breast cells), decreasing their cancer risk.

Controls growth of parathyroid gland

Aids in immune function

Muscle and gum health

Blood pressure regulation
Term
Parathyroid Hormone (PTH)
Definition
A hormone made by the parathyroid glands that increases synthesis of the vitamin D hormone and aids calcium release from bone and calcium conservation by the kidneys, among other functions.
Term
Rickets
Definition
Decreased calcium and phosphorus deposition in bones due to less vitamin D hormone activity.

A disease characterized by poor mineralization of newly synthesized bones because of low calcium content. This deficiency disease arises in infants and children from insufficient amounts of the vitamin D hormone in the body.

Symptoms include enlarged head, joints, and ribcage, and a deformed pelvis.
Term
Osteomalacia
Definition
Soft bones, an adult disease comparable to rickets. The weakening of the bones seen in this disease is caused by low calcium content. A reduction in the amount of the vitamin D hormone in the body is one cause.
Term
Vitamin D Sources
Definition
Fatty fish (sardines, salmon), fortified milk, fortified yogurt, some cereals. A little is found in eggs, butter, liver, and some margarine.
Term
High Intake of Vitamin D
Definition
Increased calcium absorption

High blood calcium - calcium depositions in the kidneys and other organs (metabolic disturbances and cell death).

Weakness, loss of appetite, diarrhea, vomiting, mental confusion, increase urine output
Term
Vitamin E Functions
Definition
Mostly resides in cell membranes as an antioxidant barrier to donate electrons or hydrogens to free radicals. Otherwise, cell DNA can be altered, causing cancer or cellular damage.

Maybe prevents or delays heart disease and some cancer (but not as supplements).
Term
Free Radicals
Definition
Highly reactive compounds containing an unpaired electron

Production of these is a normal result of cell metabolism and immune system function
Term
Vitamin E Deficiency
Definition
Preterm infants are born with low vitamin E because mother transfers vitamin E late in pregnancy. Smoking destroys vitamin E in the lungs. Very low-fat diets and fat malabsorption also increases risk.

Cell membranes break down
Term
Hemolysis
Definition
Destruction of red blood cells. The red blood cell membrane breaks down, allowing cell contents to leak into the fluid portion of the blood.
Term
Tocopherols
Definition
Chemical name for some forms of vitamin E. The alpha form is the most potent. Gamma-tocopherol is the main form in foods. Others are beta, gamma, and delta.
Term
Sources of Vitamin E
Definition
Plant oils, salad dressings, mayonnaise, cereals, asparagus, tomatoes, green leafy vegetables, eggs, margarine, whole grains, nuts, seeds.

Oxygen, metals, light, and deep-fat frying destroys vitamin E.
Term
High Vitamin E Intake
Definition
Interfere with vitamin K's role in blood clotting, leading to hemorrhage.
Term
Vitamin K Sources
Definition
Plants, plant oils, fish oils, and meats. Liver, green leafy vegetables, kale, turnip greens, dark-green lettuce, spinach, broccoli, peas, green beans, soybeans, canola oils, fortified chocolate.

Resistant to cooking loss.

Also ~10% is synthesized by bacteria in the human intestine.

Infants do not have that bacteria and need routine injections.
Term
Vitamin K Functions
Definition
Vital for blood clotting, working along with various proteins and calcium

Activates proteins present in bone, muscle, and kidneys to give them calcium-binding ability.
Term
Vitamin K Deficiency
Definition
Caused by long-term fat malabsorption or antibiotics

Increase in hip fractures
Term
Vitamin K Toxicity
Definition
Generally, there is none. No Upper Level.

Megadose use causes reduced effectiveness of oral medications used to lessen blood clotting.
Term
B Vitamins
Definition
Thiamin, riboflavin, niacin, pantothenic acid, biotin, vitamin B-6, folate, vitamin B-12

Often occur together in same foods.

Function as coenzymes.

About 50-90% are absorbed.
Term
Bioavailability
Definition
The degree to which an ingested nutrient is absorbed and thus is available to the body
Term
Vitamin B Deficiency
Definition
Caused by not eating enough. Alcoholism makes it worse.

Fatigue.

Increased risk of cardiovascular disease, cancer, and cataracts is suspected.
Term
Vitamin B Sources
Definition
Unmilled or fortified grains
Term
Thiamin (Vitamin B-1) Deficiency
Definition
Beriberi
Term
Beriberi
Definition
"I can't, I can't" in Sri Lanka's Sinhalese. Thiamin deficiency disorder characterize by muscle weakness, loss of appetite, nerve degeneration, irritability, nervous tingling throughout the body, poor arm and leg coordination, deep muscle pain in the calves, and sometimes and enlarged heart and edema.
Term
Thiamin Sources
Definition
Pork, whole grains with wheat germ, cereals, enriched grains, green beans, milk, orange juice, organ meats, peanuts, dried beans, and seeds.
Term
Riboflavin (Vitamin B-2) Functions
Definition
Coenzyme: energy yielding, esp. through oxygen-requiring pathways. Vitamin and mineral metabolism.

Antioxidation.
Term
Riboflavin Deficiency
Definition
Inflammation of the mouth and tongue, dermatitis, cracking of tissue around the corners of the mouth (cheilosis), various eye disorders, sensitivity to the sun, confusion

Symptoms take 2 months of deficiency.

Likely also a deficiency of niacin, thiamin, vitamin B-6.
Term
Sources of Riboflavin
Definition
Milk, milk products, enriched grains, cereals, meat, eggs, asparagus, broccoli, spinach, various greens
Term
Riboflavin Toxicity
Definition
No specific symptoms indicate that it exists. No Upper Level.
Term
Niacin (Vitamin B-3) Functions
Definition
Functions in the body as one of two related compounds: nicotinic acid and nicotinamide

Niacin coenzyme: energy release from energy nutrients and used by cells, synthetic pathways in cell that make new compounds (fatty acid synthesis), and almost every cellular metabolic pathway

Raises HDL-cholesterol by 15-35%
Term
Niacin Deficiency
Definition
Alcoholism, poor tryptophan metabolism, or malnutrition

Pellegra is the group of symptoms.

Poor appetite, weight loss, and weakness.

Dementia, diarrhea, and dermatitis (esp. on areas exposed to the sun).

Death.
Term
Niacin Sources
Definition
Poultry, cereals, beef, wheat bran, tuna, fish, asparagus, peanuts, and a little coffee and tea.

Heat stable, so little is lost in cooking.

~50% synthesized from tryptophan
Term
Niacin Toxicity
Definition
Headache, itching, increased blood flow to the skin

GI tract and liver damage
Term
Pantothenic Acid Functions
Definition
Helps release energy from carbohydrates, fats, and proteins.

By forming its coenzyme (coenzyme A or CoA), it allows many energy-yielding metabolic reactions to occur, activates fatty acids so they can yield energy.
Term
Pantothenic Acid Sources
Definition
Sunflower seeds, mushrooms, peanuts, eggs, meat, milk, many vegetables.
Term
Pantothenic Acid Deficiency
Definition
Deficiency is probably hidden among deficiencies of thiamin, riboflavin, B-6, and folate.
Term
Pantothenic Acid Toxicity
Definition
No known symptoms and no Upper Level
Term
Biotin Functions
Definition
Aids in fat and carbohydrate metabolism
Assists in addition of CO2 to other compounds
Promotes synthesis of glucose and fatty acids
Helps break down certain amino acids
Term
Biotin Deficiency
Definition
Scaly inflammation of the skin
Changes in the tongue and lips
Decreased appetite
Nausea
Vomiting
A form of anemia
Depression
Muscle pain and weakness
Poor growth
Term
Biotin Sources
Definition
Cauliflower, egg yolks, peanuts, cheese (avidin in raw egg white inhibits biotin absorption)

Intestinal bacteria synthesize and supply some biotin
Term
Biotin Toxicity
Definition
None.
Term
Vitamin B-6
Definition
Can exist in three chemical forms, all of which can be changed to the active vitamin B-6 coenzyme.

Pyridoxine is the general vitamin name and form added to foods
Term
Vitamin B-6 Functions
Definition
Needed in many areas of metabolism, particularly protein and amino acid and homocysteine and neurotransmitter metabolism

Coenzyme helps remove the nitrogen group from certain amino acids, making nitrogen available to another amino acid, so nonessential amino acids can be forms.

Synthesis of hemoglobin and its function to carry oxygen

Synthesis of white blood cells

Treat nausea for the first trimester of pregnancy
Term
Vitamin B-6 Deficiencies
Definition
Alcholism destroys B-6.

Depression, vomiting, skin disorders, irritation of the nerves, impaired immune response

Convulsions (lack of neurotransmitters)
Term
Vitamin B-6 Sources
Definition
Animal products, cereal, potatoes, milk, bananas, cantaloupes, broccoli, spinach
Term
Vitamin B-6 Toxicity
Definition
Easy with supplementation

Risk of developing irreversible nerve damage

Walking difficulties, hand/foot numbness
Term
Folate and Folic Acid
Definition
Folate comes from food. Contains extra units of glutamic acid (amino acid).

Folic acid is a synthetic chemical added to foods and supplements (1.7 times more easily absorbed)
Term
Folate Function
Definition
Supplies or accepts single carbon compounds.
Coenzymes help form DNA and metabolize various amino acids and their derivatives, such as homocysteine.
Term
Folate Deficiency
Definition
Pregnancy problems - neural tube defects or anencephaly (absence of a brain)

Inflammation of the tongue, diarrhea, poor growth, mental confusion, depression, and nerve function problems

Decreased red blood cell synthesis
Immature cells cannot divide and cannot form new DNA
Cells grow larger, forming megaloblasts.
Less able to carry oxygen
Term
Neural Tube Defects
Definition
A defect in the formation of the neural tube occurring during early fetal development.

This type of defect results in various nervous system disorders, such as spina bifida. Folate deficiency in the pregnant woman increases the risk that the fetus will develop this disorder.
Term
Folate Sources
Definition
Cereal, supplements, green leafy vegetables, organ meats, sprouts, dried beans, vegetables, orange juice, some in milk and bread

Susceptible to destruction by heat (50-90% by processing and preparation). Raw, steam, stir-fry, or microwave to prevent this.
Term
Folate Toxicity
Definition
Large doses can hide B-12 deficiency, so Upper Level is set.

Otherwise, no toxicity.
Term
Vitamin B-12
Definition
Family of compounds that contain the mineral cobalt. All are synthesized by bacteria, fungi, and other lower organisms.
Term
Vitamin B-12 Absorption
Definition
Enters stomach in food, digested from other materials (stomach acid, etc)

Free B-12 binds with a protein produced by the salivary glands in the mouth, protecting itself from stomach acid.

Freed in small intestine by the intrinsic factor. The intrinsic factor/B-12 complex travels to the last portion of the small intestine for absorption.

50% is absorbed.
Term
Vitamin B-12 Deficiency
Definition
At risk: Breastfed-by-vegetarian/vegan infants

Caused from defective absorption more than from inadequate intake, esp. in older individuals.

Folate deficiency, nerve destruction (after 3 years of deficiency), paralysis, death
Term
Vitamin B-12 Function
Definition
Folate metabolism
Maintaining myelin sheaths that insulate neurons from each other
Homocysteine metabolism
Certain minor metabolic pathways
Term
Pernicious Anemia
Definition
The anemia that results from a lack of vitamin B-12 absorption

It is pernicious because of associated nerve degeneration that can result in eventual paralysis and death

Weakness, sore tongue, back pain, apathy, tingling in the extremities
Term
Vitamin B-12 Sources
Definition
Meat, milk, cereal, poultry, seafood, eggs, organ meats, liver, kidneys, heart

Over 50, try synthetic sources
Term
Vitamin B-12 Toxicity
Definition
None.
Term
Vitamin C Functions
Definition
In all living tissues

Antioxidant - reduces formation of carcinogenic nitrosamines in stomach and keeps folate coenzymes intact.

Iron Absorption

Immune Function
Term
Vitamin C Toxicity
Definition
Diarrhea (unabsorbed vitamin C stays in small intestine and attracts water)

Stomach inflammation
Term
Collagen Synthesis
Definition
Vitamin C increases cross-connections between amino acids in collagen, greatly strengthening structural tissues
Term
Vitamin C Deficiency
Definition
At risk: smokers, alcoholics, old people
Widespread changes in tissue metabolism. Decrease in collagen synthesis.

Scurvy - Weakness, slow wound healing, opening of previously healed wounds, bone pain, fractures, bleeding gums, diarrhea, pinpoint hemorrhages around hair follicles on the back of the arms and legs.
Term
Vitamin C Sources
Definition
Citrus fruits, green peppers, cauliflower, broccoli, cabbage, strawberries, papayas, romaine lettuce. Also, potatoes, cereal, fortified fruit drinks.

Lost in heat, iron, copper, oxygen, and thrown-out water.
Term
Choline Functions
Definition
Part of acetylcholine, a neurotransmitter associated with attention, learning and memory, muscle control.

Part of phospholipids, such as lecithin, the major component of the cell membrane.

Participates in some aspects of homocysteine metabolism.
Term
Choline Deficiency
Definition
Only one published study - liver damage

Essential, but not yet a vitamin
Term
Choline Sources
Definition
Milk, liver, peanuts. Lecithins.
Term
Choline Toxicity
Definition
Fishy body odor and low blood pressure, so Upper Level set.
Term
Vitamin-like Compounds
Definition
Only essential during disease states.
Term
Should You Take a Supplement?
Definition
Talk to your doctor.

Supplement use cannot fix a poor diet in all respects and uninformed megadose supplement use can lead to harm.

Experts say only certain groups benefit.
Women of childbearing age may need extra folic acid.
Women with excessive bleeding during menstruation may need extra iron.
Women who are pregnant/breastfeeding may need extra iron, folate, and calcium.
Strict vegans may need extra calcium, iron, zinc, and B-12/
People with low-caloric intakes (less than 1200 kcal/day).
Newborns need a single dose of vitamin K
Older infants may need flouride supplements
People with limited milk intake and sunlight exposure may need extra vitamin D.
People with dairy allergies may need extra calcium.
People over age 50 may need a synthetic source of B-12.
People on low-fat diets may need extra vitamin E.
Term
Water Functions
Definition
Acts as a solvent
Allows for chemical reactions to occur
Contributes to body temperature regulation
Helps remove waste products
Primary component of body fluids, such as in joints
Term
Water Content in Body
Definition
50-70% of body weight
73% of lean muscle tissue
20% of adipose tissue
Term
Intracellular Fluid
Definition
Fluid contained within a cell
2/3 of body fluid
Term
Extracellular Fluid
Definition
Fluid contained outside a cell
1/3 of body fluid
Term
Electrolytes
Definition
Ions (sodium, potassium, chloride, phosphate, magnesium, and calcium) attract water
Term
Urea
Definition
Nitrogenous waste product of protein metabolism
Major source of nitrogen in the urine

By limiting excess protein and salt intakes, it is possible to limit urine output.
Term
Adequate Intake for Water
Definition
3.7 liters (15 cups) for men. 2.7 liters (11 cups) for women.
Term
Body Weight Loss Due to Fluid
Between 0-2%
Between 2-4%
Between 4-6%
Between 6-8%
Between 8-10%
Over 10%
Definition
Between 0-2% - thirst

Between 2-4% - Nausea, emotional instability, impatience, weariness, lagging pace, flushed skin

Between 4-6% - Tingling in arms, hands, feet; stumbling, headache, heat exhaustion (faintness, dizziness, fatigue, nausea, headache, increase body temperature, pulse, and respiratory rate)

Between 6-8% - Labored breathing, dizziness, cyanosis (bluish color of the skin), indistinct speech, increasing weakness, mental confusion

Between 8-10% - muscle cramps, inability to balance with eyes closed, general incapacity, delirium and wakefulness, swollen tongue, circulatory insufficiency, marked hemoconcentration and decreased blood volume, failing kidney function
Over 10% - Death
Term
Health Beverage Consumption Guidelines
Definition
Beverages should provide less than 10% of total calories consumed for a 2200 kcal diet.
Term
Water Toxicity
Definition
Kidneys cannot excrete
Electrolyte concentration too low

Blurred vision
Nausea
Term
Tap or Bottled Water?
Definition
Tap may be contaminated with the parasite Cryptosporidium. AIDS and other immune system deficiencies should boil water to kill it, but healthy people are fine.
Term
Oxalic Acid (Oxalate)
Definition
An organic acid found in spinach, rhubarb, and other leafy green vegetables that can depress the absorption of certain minerals present in the food, such as calcium.
Term
Animal and Plant Sources of Minerals
Definition
Animal sources are superior because they do not have the binders like fiber than plants do.

Also, plant sources are very dependent on soil type.

Yeast can break some of the binders in bread.
Term
Phytic Acid (Phytate)
Definition
A constituent of plant fibers that binds positive ions to its multiple phosphate groups
Term
Sodium Absorption
Definition
About 100%
Term
Sodium (Na) Functions
Definition
Major positive ion in extracellular fluid
Helps body retain water
Nerve impulse conduction
Absorption of some nutrients (glucose)
Term
Sodium Deficiency
Definition
Caused by diet low in sodium with excessive perspiration, persistent vomiting, or diarrhea

Muscle cramps, nausea, vomiting, dizziness, shock, coma
Term
Sodium Sources
Definition
Everything, esp. milk.

White bread, rolls, hot dogs, lunch meats, cheese, soups, tomato sauce, snack foods, French fries, potato chips, sauces, gravies
Term
Potassium (K) Functions
Definition
Fluid balance inside cells
Nerve impulse transmission
Term
Potassium Absorption
Definition
90%
Term
Potassium Deficiency
Definition
Life-threatening.

Loss of appetite, muscle cramps, confusion, constipation

Irregular heartbeat
Term
Potassium Sources
Definition
Unprocessed foods. Fruits, vegetables, whole grains, dried beans, meats, milk, potatoes, beef, coffee, tomatoes, orange juice.
Term
Diuretics
Definition
Substance that increases the volume of urine. Can lower blood pressure and deplete body's potassium.
Term
Potassium Toxicity
Definition
If kidneys function normally, no Upper Level needed.
Term
Chloride (Cl) Function
Definition
Important negative ion for the extracellular fluid
Ions are a component of the acid produced in the stomach
Used during immune responses
Term
Chloride Deficiency
Definition
Caused by low intake, frequent and lengthy bouts of vomiting
Term
Chloride Sources
Definition
Salt
Term
Calcium (Ca) Functions
Definition
99% used to strengthen bones and teeth
40% of all minerals present in body
Present in all cells
Growth and bone development
Blood clotting
Assists flow of ions in and out of nerve cells
Regulates cellular metabolism by influencing the activities of various enzymes and hormonal responses
Reduces risk of certain cancers, kidney stones, hypertension, high blood cholesterol, obesity
Term
Calcium Absorption
Definition
Primarily in upper part of the small intestine (most acidic portion). Depends on active vitamin D hormone.

Enhanced by blood levels of parathyroid hormone, presence of glucose and lactose in the diet, gradual flow of digestive contents through the intestine.

Limited by large amounts of phytic acid in fiber, great excess of phosphorus in the diet, polyphenols in tea, vitamin D deficiency, diarrhea, old age.
Term
Osteoporosis
Definition
Decreased bone mass related to the effects of aging, genetic background, and poor diet in both genders, and hormonal changes at menopause in women
Term
Tetany
Definition
Body condition marked by sharp contraction of muscles and failure to relax afterward

Usually caused by abnormal calcium metabolism
Term
Calcium Deficiency
Definition
Bone loss
Term
Calcium Sources
Definition
Cheese, milk, bread, rolls, crackers, leafy greens, spinach, broccoli, sardines, canned salmon
Term
Calcium Toxicity
Definition
High blood and urinary calcium concentrations, irritability, headache, kidney failure, soft tissue calcification, decreased absorption of other minerals
Term
Phosphorus (P) Function
Definition
Component of enzymes, DNA, cell membranes, (85%) bone
Term
Phosphorus Absorption
Definition
70%
Active vitamin D enhances
Term
Phosphorus Sources
Definition
Milk, cheese, meat, bread, cereal, bran, eggs, nut, fish, baked goods, processed meats, soft drinks
Term
Phosphorus Deficiencies
Definition
Found in preterm infants, vegans, alcoholics, older people, long-term diarrhea
Term
Phosphorus Toxicity
Definition
Imbalance in calcium-to-phosphorus balance
Hurts kidneys
Term
Magnesium (Mg) Functions
Definition
Nerve and heart function
Enzyme reactions
60% is in bone
Term
Magnesium Sources
Definition
Milk, meats, whole grains, broccoli, potatoes, squash, beans, nuts, seeds, chocolate, tap, coffee
Term
Magnesium Deficiency
Definition
Irregular heartbeat
Weakness
Muscle pain
Disorientation
Seizures
Term
Magnesium Toxicity
Definition
Diarrhea
Term
Sulfur (S) Sources
Definition
Found in amino acids, biotin, thiamin, proteins, preservatives
Term
Sulfur Functions
Definition
Helps balance of acids and bases in body
Part of liver's drug-detoxifying pathways
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