Term 
         | 
        
        
        Definition 
        
        Building blocks for proteins
  Carry C, H, O, N
  Has an acid group, amino group, and a unique side (R) group. 
  20 different kinds: 11 nonessential and 9 essential
  11 % of the total protein dietary requirement must be supplied by essential amino acids. 
  "Typical American diets" supply 50% as essential amino acids. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Crucial to the regulation and maintenance of the body.
  Producing vital body structures Blood clotting Fluid balance Contributing to ccid-base balance Hormone and enzyme production Visual processes Transport of many substances in the bloodstream Cell repair Immune Function Glucose formation Niacin formation (from tryptophan) Providing Energy Satiety |  
          | 
        
        
         | 
        
        
        Term 
        
        | Branched-chain Amino Acids |  
          | 
        
        
        Definition 
        
        Side (R) group on these amino acids has a branched shape. 
  Primary amino acids used by muscles for energy needs
  Include leucine, isoleucine, and valine (whey proteins) |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Alcoholism can lead to it. 
  Body tries to conserve amino acids
  Eventually, body progressively slows production of new proteins until proteins are broken down more quickly than they are made
  Also, concentration of protein in the bloodstream drops below normal causing excessive fluid build up in surrounding tissues. Edema results. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Estimated Essential Amino Acid Needs for Infants and Children |  
          | 
        
        
        Definition 
        
        Infants and preschool children: 40% of total protein intake (Try breast milk or formula)
  Later childhood: 20% of total protein intake (Try cow's milk) |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Limits body's ability to metabolize the essential amino acid phenylalanine
  Causes activity of the enzyme used in processing phenylalanine to tyrosine is insufficient
  Tyrosine becomes an essential amino acid
  Phenylalanine levels in the blood can increase to toxicity and cause severe mental retardation |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Link together amino acids to form proteins
  Acids, enzymes, and other agents are able to break them. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Takes place in cytoplasm
  Enzymes in nucleus read code on one segment (gene) of one DNA strand and transcribe the information onto mRNA 
  mRNA travels to the ribosomes
  Ribosomes translate instructions to produce a specific protein
  Amino acids are added one at a time to the polypeptide chain 
  tRNA brings specific amino acids to the ribosomes as needed during protein synthesis
  Energy input is required to add each amino acid to the chain, making protein synthesis "costly" in terms of calorie use
  Once polypeptide chain is complete, it twists and folds into the correct structure. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Chain of 50-2000+ amino acids bonded together. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Sickle Cell Disease (Sickle Cell Anemia) |  
          | 
        
        
        Definition 
        
        North Americans of African descent are esp. prone to this genetic disease
  Causes defects in the amino-acid order of two of the four protein chains of hemoglobin
  Red blood cells become a sickle shape and no longer carry oxygen efficently
  Health deteriorates, and eventually episodes of severe pain in the bones and joints, abdominal pain, headaches, convulsions, and paralysis may occur |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Alteration of a protein's structure by exposure to acid, alkaline, heat, or agitation
  Uncoils or otherwise deforms the protein
  Usually destroys its ability to function normally
  Digestion denatures consumed proteins. Sometimes, this can reduce their tendencies to cause allergic reactions. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Either all essential amino acids are available or none can be used in protein synthesis
  Remaining amino acids are used for energy needs or converted to carbohydrate or fat |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Food allergies occur in 8% of children 4 years of age or younger and 2% of adults.
  90% of food allergies are soy, peanuts, tree nuts, wheat, milk, egg, fish, shellfish |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Food is cooked: protein is denatured, tough connective tissue is softened, generally easier to chew and swallow
  Enzymatic digestion of protein in stomach Stomach acid denatures proteins Hormone gastrin regulates release of enzyme pepsin breaks unraveled polypeptide chains into shorter chains of amino acids
  Partially digested proteins enter small intestine
  Hormone cholecystokinin (CCK) released from intestine walls
  CCK travels through the bloodstream to the pancreas. The pancreas releases protein-splitting enzymes, such as trypsin.
  Chain sizes reduced to one or two-three amino acids.
  Enzymes separate amino acids |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Hormone that controls release of pepsin and strongly stimulates stomach acid production
  Triggered by thinking about food or chewing food |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Individual and short chains of amino acids in the small intestine are taken up by active transport into the absorptive cells lining the small intestine
  Remaining peptide bonds are broken down to yield individual amino acids inside the intestinal cells. 
  Amino acids travel via the portal vein to the liver.
  The liver can severely modify amino acids according to body's needs. Maybe combined into proteins, broken down for energy needs, released into the bloodstream, or converted to nonessential amino acids, glucose, or fat. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Protein Absorption During Infancy |  
          | 
        
        
        Definition 
        
        4-5 months of age: GI tract is somewhat permeable to small proteins, so some whole proteins can be absorbed. 
  Wait until 6-12 months before introducing commonly allergenic foods (like cow's milk and egg whites) |  
          | 
        
        
         | 
        
        
        Term 
        
        | Proteins Produce Vital Body Structures |  
          | 
        
        
        Definition 
        
        Muscles, connective tissue, mucus, blood-clotting factors, transport proteins in the bloodstream, lipoproteins, enzymes, immune antibodies, some hormones, visual pigments, ans the support structure inside bones are primarily protein. 
  Excess protein in the diet cannot enhance synthesis, but inadequate consumption can prevent it. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        The process by which cells break down old proteins and resynthesize new proteins so that cells will have the proteins it needs to function at that time.
  Daily, adults make and degrade ~250g of protein. 65-100g is consumed daily. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Proteins Maintain Fluid Balance |  
          | 
        
        
        Definition 
        
        Normal blood pressure in arteries force blood into capillary beds. Blood fluid moves from capillary beds into extracellular spaces to provide nutrients to cells. 
  Proteins are too large to move out of capillary beds into the tissues, so they attract the proper amount of fluid back to the blood, partially counteracting the force of blood pressure. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Network of one-cell-thick vessels that create a junction between arterial and venous circulation. It is here that gas and nutrient exchange occurs between body cells and the blood. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Buildup of excess fluid in extracellular spaces
  May be a symptom of a variety of medical problems, so its cause must be identified. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Proteins Contribute to Acid-Base Balance |  
          | 
        
        
        Definition 
        
        Proteins located in cell membranes pump chemical ions in and out of cells, keeping the blood slightly alkaline. 
  Some blood proteins are esp. good buffers, maintaining acid-base conditions within a narrow range. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Compounds that cause a solution to resist changes in acid-base conditions |  
          | 
        
        
         | 
        
        
        Term 
        
        | Proteins Form Hormones and Enzymes |  
          | 
        
        
        Definition 
        
        Some hormones like the thyroid hormones are made from only one type of amino acid, tyrosine.
  One the other hand, insulin is a hormone composed of 51 amino acids. 
  Neurotransmitters are often derivatives of amino acids, like dopamine and norepinephrine (both synthesized from tyrosine) and serotonin (synthesized from tryptophan). |  
          | 
        
        
         | 
        
        
        Term 
        
        | Proteins Contribute to Immune Function |  
          | 
        
        
        Definition 
        
        Antibodies are proteins produced by one type of white blood cell and bind foreign proteins in the body. 
  Low protein status can turn measles into a fatal disease for a malnourished child. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        During prolonged exercise During calorie restriction
  The amino group is removed and the remaining carbon skeleton is metabolized for energy needs. 
  Proteins are a costly source of calories. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Proteins Contibute to Satiety |  
          | 
        
        
        Definition 
        
        | Highest feeling of satiety after a meal. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Protein Equilibrium (Protein Balance) |  
          | 
        
        
        Definition 
        
        | Protein leaves the body in the urea, hair loss, skin loss, feces, nail loss |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        When body is growing or recovering from an illness or injury
  Insuline, growth hormone, and testosterone stimulate positive protein balance |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Acute illness reduces the desire to eat and causes one to lose more protein than is consumed |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        .8g per kg of healthy body weight Higher during pregnancy, growth, infancy
  10% of total calories. Experts also suggest 15% or up to 35%. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Likely also a diet high in cholesterol and saturated fat and low in fiber, some vitamins, some minerals, and phytochemicals.
  Moderate rather than high protein intake is better for kidney health. Limit protein in early stages of kidney disease because somewhat lessens kidney function. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Protein-Calorie Malnutrition (PCM) or Protein-Energy Malnutrition (PEM) |  
          | 
        
        
        Definition 
        
        | A condition resulting from regularly consuming insufficient amounts of calories and protein. Results in body wasting, primarily of lean tissue and an increased susceptibility to infections. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        A disease occurring primarily in young children who have an existing disease and consume a marginal amount of calories and insufficient protein in relation to needs. Infections, edema, poor growth, weakness, and an increased susceptibility to further illness occurs.
  Ghana: "the disease that the first child gets when the new child comes". Breastfed to gruels. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        A disease resulting from consuming a grossly insufficient amount of protein and calories
  Victims have little or no fat stores, little muscle mass, and poor strength
  Death from infections is common |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Compounds needed in small amounts in the diet to help regulate and support chemical reactions and processes in the body
  1. Is essential 2. Absence causes health decline. Return improves health. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        B C
  Readily excreted from the body with any excess in urine or stool. Very little is stored. Preserve in foods by light cooking methods, such as stir-frying, steaming, and microwaving. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Intake of a nutrient beyond estimates of needs to prevent a deficiency or what would be found in a balanced diet; 2 to 10 times human needs is a starting point for such a pharmacological dosage.
  Used in treatment of a few vitamin deficiencies. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Quality of Vitamin Sources |  
          | 
        
        
        Definition 
        
        Plant, animal, and laboratory (isolated or synthesized) are the same chemical compounds and generally work equally well. 
  Vitamin E is much more potent in its natural form han in its synthetic form. Synthetic folic acid (in cereal and flour) is 1.7 times more potent than the natural form. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Storage of Vitamins in the Body |  
          | 
        
        
        Definition 
        
        K is only fat soluble readily excreted from the body. Water soluble are rapidly lost from the body, except for B-6 and B-12, which are more readily stored. 
  Daily consumption necessary. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Vitamin A is the most frequently observed. Overconsumption of fish oils can cause it. 
  Vitamin E, niacin, B-6, and C must be consumed 15-100 times human needs to become toxic. 
  Toxicity usually caused by supplements. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Preservation of Vitamins in Food |  
          | 
        
        
        Definition 
        
        Water-soluble (thiamin, C, folate) can be destroyed with improper storage and excessive cooking. 
  Heat, light, exposure to the air, cooking in water, and alkalinity destroy vitamins.
  Sooner a food is eaten after harvest, the less chance of nutrient loss. Maybe blanch (destroy enzymes that break down vitamins) then freeze if not eaten within a few days. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Aborption of Fat-Soluble Vitamins |  
          | 
        
        
        Definition 
        
        Absorbed with dietary fat. 
  Travel with dietary fat through bloodstream to body cells. Special carries in the bloodstream help distribute some of these vitamins. Stored mostly in the liver and fatty tissues.
  Efficient absorption: 40-90% are absorbed. Cystic fibrosis inhibits fat absorption and may cause fat-soluble vitamin deficiency.  Weight-loss drugs like Xenical can interfere with fat absorption.  Mineral oil is not absorbed and can carry fat soluble vitamins out of the body.
  Unabsorbed fat and vitamins go to the large intestine and are excreted in the feces. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Preformed vitamin A
  Only found in foods of animal origin |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Provitamin A
  Plant pigments contain this. 
  Beta-carotene, orange-yellow pigment in carrots, is the most potent form of provitamin A. 
  Lutein and Zeaxanthin. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Light-dark vision Color vision (to a lesser extent) Retinal: adjust from bright to dim light
  Maintains health of the epithelial cells of internal and external surfaces of lungs, intestines, stomach, vagina, urinary tract, eyes, skin, and bladder
  Certain immune system cells
  Growth, Development, Reproduction
  Cardiovascular Disease Prevention - carotenoids' antioxidant capability
  Cancer prevention - skin, lung, bladder, breast cancers, prostate gland |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Early sign of vitamin A deficiency Inadequate retinol Cannot quickly readjust from bright to dim light |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Cells that line the cornea of the eye lose ability to produce mucus.
  Eye becomes dry and easily scratched by dirt and infected. Infection can cause blindness.
  Only accidents case more cases of blindness in the world. Diabetes causes more in N. America. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        A thick fluid secreted by many cells throughout the body. It contains a compound that has both carbohydrate and protein parts. It acts as a lubricant and means of protection for cells. 
  Present in cornea. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Dry eye: Cause of blindness from vitamin A deficiency. A lack of mucus production by the eye leaves it at a greater risk of damage from surface dirt and bacteria. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Leading cause of legal blindness among N. American adults over the age of 65. 
  Macular area of the eye provides the most detailed vision. 
  Age, smoking, and genetics are risk factors. 
  Carotenoids lower the risk for developing this and cataracts. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | A chemical compound that differs slightly from another, usually natural, compound. Analogs generally contain extra or altered chemical groups and may have similar or opposite metabolic effects compared with the native compound. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Vitamin A and Acne Treatment |  
          | 
        
        
        Definition 
        
        Retin-A is made of one analog form of vitamin A (topical treatment): irritates, peels skin. blocks skin bacteria from acne lesions.
  Accutane (oral) for serious acne. Regulates development of cells in the skin. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Preformed: Liver, fish oils, fortified milk, fortified yogurt, eggs, margarine.
  Provitamin: dark green and yellow-orange vegetables and some fruits. Carrots, spinach, greens, winter squash, sweet potatoes, broccoli, mangoes, cantaloupe, peaches, and apricots. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        High intake of preformed vitamin A can cause fetal malformations and spontaneous abortions. 
  The skin can turn yellow-orange. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        A cholesterol-like substance in the skin cells is converted to the prohormone vitamin D when exposed to ultraviolet B (UVB) rays.
  Liver and kidney cells convert the prohormone into its active hormone form. 
  Provides about 80%-100% of the "average" individual's vitamin D needs. Affected by skin color, age, time of day, season, and location. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Help regulate calcium and bone metabolism
  Works with parathyroid hormone (PTH) to closely regulate blood calcium so that the appropriate amounts of it will be supplied to all cells. 
  Ensures normal development of some cells (skin, colon, prostate, ovary, and breast cells), decreasing their cancer risk.
  Controls growth of parathyroid gland 
  Aids in immune function
  Muscle and gum health
  Blood pressure regulation |  
          | 
        
        
         | 
        
        
        Term 
        
        | Parathyroid Hormone (PTH) |  
          | 
        
        
        Definition 
        
        | A hormone made by the parathyroid glands that increases synthesis of the vitamin D hormone and aids calcium release from bone and calcium conservation by the kidneys, among other functions. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Decreased calcium and phosphorus deposition in bones due to less vitamin D hormone activity.
  A disease characterized by poor mineralization of newly synthesized bones because of low calcium content. This deficiency disease arises in infants and children from insufficient amounts of the vitamin D hormone in the body.
  Symptoms include enlarged head, joints, and ribcage, and a deformed pelvis. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Soft bones, an adult disease comparable to rickets. The weakening of the bones seen in this disease is caused by low calcium content. A reduction in the amount of the vitamin D hormone in the body is one cause. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Fatty fish (sardines, salmon), fortified milk, fortified yogurt, some cereals. A little is found in eggs, butter, liver, and some margarine. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Increased calcium absorption
  High blood calcium - calcium depositions in the kidneys and other organs (metabolic disturbances and cell death).
  Weakness, loss of appetite, diarrhea, vomiting, mental confusion, increase urine output |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Mostly resides in cell membranes as an antioxidant barrier to donate electrons or hydrogens to free radicals. Otherwise, cell DNA can be altered, causing cancer or cellular damage.
  Maybe prevents or delays heart disease and some cancer (but not as supplements). |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Highly reactive compounds containing an unpaired electron
  Production of these is a normal result of cell metabolism and immune system function |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Preterm infants are born with low vitamin E because mother transfers vitamin E late in pregnancy. Smoking destroys vitamin E in the lungs. Very low-fat diets and fat malabsorption also increases risk.
  Cell membranes break down |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Destruction of red blood cells. The red blood cell membrane breaks down, allowing cell contents to leak into the fluid portion of the blood. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Chemical name for some forms of vitamin E. The alpha form is the most potent. Gamma-tocopherol is the main form in foods. Others are beta, gamma, and delta. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Plant oils, salad dressings, mayonnaise, cereals, asparagus, tomatoes, green leafy vegetables, eggs, margarine, whole grains, nuts, seeds. 
  Oxygen, metals, light, and deep-fat frying destroys vitamin E. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Interfere with vitamin K's role in blood clotting, leading to hemorrhage. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Plants, plant oils, fish oils, and meats. Liver, green leafy vegetables, kale, turnip greens, dark-green lettuce, spinach, broccoli, peas, green beans, soybeans, canola oils, fortified chocolate.
  Resistant to cooking loss.
  Also ~10% is synthesized by bacteria in the human intestine.
  Infants do not have that bacteria and need routine injections. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Vital for blood clotting, working along with various proteins and calcium
  Activates proteins present in bone, muscle, and kidneys to give them calcium-binding ability. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Caused by long-term fat malabsorption or antibiotics
  Increase in hip fractures |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Generally, there is none. No Upper Level. 
  Megadose use causes reduced effectiveness of oral medications used to lessen blood clotting. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Thiamin, riboflavin, niacin, pantothenic acid, biotin, vitamin B-6, folate, vitamin B-12
  Often occur together in same foods. 
  Function as coenzymes.
  About 50-90% are absorbed. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | The degree to which an ingested nutrient is absorbed and thus is available to the body |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Caused by not eating enough. Alcoholism makes it worse.
  Fatigue.
  Increased risk of cardiovascular disease, cancer, and cataracts is suspected. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Unmilled or fortified grains |  
          | 
        
        
         | 
        
        
        Term 
        
        | Thiamin (Vitamin B-1) Deficiency |  
          | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | "I can't, I can't" in Sri Lanka's Sinhalese. Thiamin deficiency disorder characterize by muscle weakness, loss of appetite, nerve degeneration, irritability, nervous tingling throughout the body, poor arm and leg coordination, deep muscle pain in the calves, and sometimes and enlarged heart and edema. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Pork, whole grains with wheat germ, cereals, enriched grains, green beans, milk, orange juice, organ meats, peanuts, dried beans, and seeds. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Riboflavin (Vitamin B-2) Functions |  
          | 
        
        
        Definition 
        
        Coenzyme: energy yielding, esp. through oxygen-requiring pathways. Vitamin and mineral metabolism. 
  Antioxidation. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Inflammation of the mouth and tongue, dermatitis, cracking of tissue around the corners of the mouth (cheilosis), various eye disorders, sensitivity to the sun, confusion
  Symptoms take 2 months of deficiency. 
  Likely also a deficiency of niacin, thiamin, vitamin B-6. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Milk, milk products, enriched grains, cereals, meat, eggs, asparagus, broccoli, spinach, various greens |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | No specific symptoms indicate that it exists. No Upper Level. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Niacin (Vitamin B-3) Functions |  
          | 
        
        
        Definition 
        
        Functions in the body as one of two related compounds: nicotinic acid and nicotinamide 
  Niacin coenzyme: energy release from energy nutrients and used by cells, synthetic pathways in cell that make new compounds (fatty acid synthesis), and almost every cellular metabolic pathway 
  Raises HDL-cholesterol by 15-35% |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Alcoholism, poor tryptophan metabolism, or malnutrition
  Pellegra is the group of symptoms. 
  Poor appetite, weight loss, and weakness.
  Dementia, diarrhea, and dermatitis (esp. on areas exposed to the sun).
  Death. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Poultry, cereals, beef, wheat bran, tuna, fish, asparagus, peanuts, and a little coffee and tea. 
  Heat stable, so little is lost in cooking.
  ~50% synthesized from tryptophan |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Headache, itching, increased blood flow to the skin
  GI tract and liver damage |  
          | 
        
        
         | 
        
        
        Term 
        
        | Pantothenic Acid Functions |  
          | 
        
        
        Definition 
        
        Helps release energy from carbohydrates, fats, and proteins. 
  By forming its coenzyme (coenzyme A or CoA), it allows many energy-yielding metabolic reactions to occur, activates fatty acids so they can yield energy. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Sunflower seeds, mushrooms, peanuts, eggs, meat, milk, many vegetables. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Pantothenic Acid Deficiency |  
          | 
        
        
        Definition 
        
        | Deficiency is probably hidden among deficiencies of thiamin, riboflavin, B-6, and folate. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Pantothenic Acid Toxicity |  
          | 
        
        
        Definition 
        
        | No known symptoms and no Upper Level |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Aids in fat and carbohydrate metabolism Assists in addition of CO2 to other compounds Promotes synthesis of glucose and fatty acids Helps break down certain amino acids |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Scaly inflammation of the skin Changes in the tongue and lips Decreased appetite Nausea Vomiting A form of anemia Depression Muscle pain and weakness Poor growth |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Cauliflower, egg yolks, peanuts, cheese (avidin in raw egg white inhibits biotin absorption)
  Intestinal bacteria synthesize and supply some biotin |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Can exist in three chemical forms, all of which can be changed to the active vitamin B-6 coenzyme.
  Pyridoxine is the general vitamin name and form added to foods |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Needed in many areas of metabolism, particularly protein and amino acid and homocysteine and neurotransmitter metabolism
  Coenzyme helps remove the nitrogen group from certain amino acids, making nitrogen available to another amino acid, so nonessential amino acids can be forms.
  Synthesis of hemoglobin and its function to carry oxygen
  Synthesis of white blood cells
  Treat nausea for the first trimester of pregnancy |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Alcholism destroys B-6.
  Depression, vomiting, skin disorders, irritation of the nerves, impaired immune response
  Convulsions (lack of neurotransmitters) |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Animal products, cereal, potatoes, milk, bananas, cantaloupes, broccoli, spinach |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Easy with supplementation 
  Risk of developing irreversible nerve damage
  Walking difficulties, hand/foot numbness |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Folate comes from food. Contains extra units of glutamic acid (amino acid).
  Folic acid is a synthetic chemical added to foods and supplements (1.7 times more easily absorbed) |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Supplies or accepts single carbon compounds. Coenzymes help form DNA and metabolize various amino acids and their derivatives, such as homocysteine. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Pregnancy problems - neural tube defects or anencephaly (absence of a brain)
  Inflammation of the tongue, diarrhea, poor growth, mental confusion, depression, and nerve function problems
  Decreased red blood cell synthesis Immature cells cannot divide and cannot form new DNA Cells grow larger, forming megaloblasts. Less able to carry oxygen |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        A defect in the formation of the neural tube occurring during early fetal development.
  This type of defect results in various nervous system disorders, such as spina bifida. Folate deficiency in the pregnant woman increases the risk that the fetus will develop this disorder. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Cereal, supplements, green leafy vegetables, organ meats, sprouts, dried beans, vegetables, orange juice, some in milk and bread
  Susceptible to destruction by heat (50-90% by processing and preparation). Raw, steam, stir-fry, or microwave to prevent this. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Large doses can hide B-12 deficiency, so Upper Level is set. 
  Otherwise, no toxicity. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Family of compounds that contain the mineral cobalt. All are synthesized by bacteria, fungi, and other lower organisms. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Enters stomach in food, digested from other materials (stomach acid, etc)
  Free B-12 binds with a protein produced by the salivary glands in the mouth, protecting itself from stomach acid.
  Freed in small intestine by the intrinsic factor. The intrinsic factor/B-12 complex travels to the last portion of the small intestine for absorption. 
  50% is absorbed. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        At risk: Breastfed-by-vegetarian/vegan infants
  Caused from defective absorption more than from inadequate intake, esp. in older individuals.
  Folate deficiency, nerve destruction (after 3 years of deficiency), paralysis, death |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Folate metabolism Maintaining myelin sheaths that insulate neurons from each other Homocysteine metabolism  Certain minor metabolic pathways |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        The anemia that results from a lack of vitamin B-12 absorption
  It is pernicious because of associated nerve degeneration that can result in eventual paralysis and death
  Weakness, sore tongue, back pain, apathy, tingling in the extremities |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Meat, milk, cereal, poultry, seafood, eggs, organ meats, liver, kidneys, heart
  Over 50, try synthetic sources |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        In all living tissues
  Antioxidant - reduces formation of carcinogenic nitrosamines in stomach and keeps folate coenzymes intact. 
  Iron Absorption
  Immune Function |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Diarrhea (unabsorbed vitamin C stays in small intestine and attracts water)
  Stomach inflammation |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Vitamin C increases cross-connections between amino acids in collagen, greatly strengthening structural tissues |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        At risk: smokers, alcoholics, old people Widespread changes in tissue metabolism. Decrease in collagen synthesis.
  Scurvy - Weakness, slow wound healing, opening of previously healed wounds, bone pain, fractures, bleeding gums, diarrhea, pinpoint hemorrhages around hair follicles on the back of the arms and legs. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Citrus fruits, green peppers, cauliflower, broccoli, cabbage, strawberries, papayas, romaine lettuce. Also, potatoes, cereal, fortified fruit drinks. 
  Lost in heat, iron, copper, oxygen, and thrown-out water. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Part of acetylcholine, a neurotransmitter associated with attention, learning and memory, muscle control.
  Part of phospholipids, such as lecithin, the major component of the cell membrane.
  Participates in some aspects of homocysteine metabolism. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Only one published study - liver damage
  Essential, but not yet a vitamin |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Milk, liver, peanuts. Lecithins. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Fishy body odor and low blood pressure, so Upper Level set. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Only essential during disease states. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Should You Take a Supplement? |  
          | 
        
        
        Definition 
        
        Talk to your doctor. 
  Supplement use cannot fix a poor diet in all respects and uninformed megadose supplement use can lead to harm. 
  Experts say only certain groups benefit.  Women of childbearing age may need extra folic acid. Women with excessive bleeding during menstruation may need extra iron. Women who are pregnant/breastfeeding may need extra iron, folate, and calcium. Strict vegans may need extra calcium, iron, zinc, and B-12/ People with low-caloric intakes (less than 1200 kcal/day). Newborns need a single dose of vitamin K Older infants may need flouride supplements People with limited milk intake and sunlight exposure may need extra vitamin D. People with dairy allergies may need extra calcium. People over age 50 may need a synthetic source of B-12. People on low-fat diets may need extra vitamin E. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Acts as a solvent  Allows for chemical reactions to occur Contributes to body temperature regulation  Helps remove waste products Primary component of body fluids, such as in joints |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        50-70% of body weight 73% of lean muscle tissue 20% of adipose tissue |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Fluid contained within a cell 2/3 of body fluid |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Fluid contained outside a cell 1/3 of body fluid |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Ions (sodium, potassium, chloride, phosphate, magnesium, and calcium) attract water |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Nitrogenous waste product of protein metabolism Major source of nitrogen in the urine
  By limiting excess protein and salt intakes, it is possible to limit urine output. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Adequate Intake for Water |  
          | 
        
        
        Definition 
        
        | 3.7 liters (15 cups) for men. 2.7 liters (11 cups) for women. |  
          | 
        
        
         | 
        
        
        Term 
        
        Body Weight Loss Due to Fluid Between 0-2%  Between 2-4% Between 4-6% Between 6-8% Between 8-10% Over 10% |  
          | 
        
        
        Definition 
        
        Between 0-2% - thirst
  Between 2-4% - Nausea, emotional instability, impatience, weariness, lagging pace, flushed skin
  Between 4-6% - Tingling in arms, hands, feet; stumbling, headache, heat exhaustion (faintness, dizziness, fatigue, nausea, headache, increase body temperature, pulse, and respiratory rate)
  Between 6-8% - Labored breathing, dizziness, cyanosis (bluish color of the skin), indistinct speech, increasing weakness, mental confusion
  Between 8-10% - muscle cramps, inability to balance with eyes closed, general incapacity, delirium and wakefulness, swollen tongue, circulatory insufficiency, marked hemoconcentration and decreased blood volume, failing kidney function Over 10% - Death |  
          | 
        
        
         | 
        
        
        Term 
        
        | Health Beverage Consumption Guidelines |  
          | 
        
        
        Definition 
        
        | Beverages should provide less than 10% of total calories consumed for a 2200 kcal diet. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Kidneys cannot excrete Electrolyte concentration too low
  Blurred vision Nausea |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Tap may be contaminated with the parasite Cryptosporidium. AIDS and other immune system deficiencies should boil water to kill it, but healthy people are fine. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | An organic acid found in spinach, rhubarb, and other leafy green vegetables that can depress the absorption of certain minerals present in the food, such as calcium. |  
          | 
        
        
         | 
        
        
        Term 
        
        | Animal and Plant Sources of Minerals |  
          | 
        
        
        Definition 
        
        Animal sources are superior because they do not have the binders like fiber than plants do. 
  Also, plant sources are very dependent on soil type. 
  Yeast can break some of the binders in bread. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | A constituent of plant fibers that binds positive ions to its multiple phosphate groups |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Major positive ion in extracellular fluid Helps body retain water Nerve impulse conduction  Absorption of some nutrients (glucose) |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Caused by diet low in sodium with excessive perspiration, persistent vomiting, or diarrhea
  Muscle cramps, nausea, vomiting, dizziness, shock, coma |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Everything, esp. milk.
  White bread, rolls, hot dogs, lunch meats, cheese, soups, tomato sauce, snack foods, French fries, potato chips, sauces, gravies |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Fluid balance inside cells Nerve impulse transmission |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Life-threatening.
  Loss of appetite, muscle cramps, confusion, constipation
  Irregular heartbeat |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Unprocessed foods. Fruits, vegetables, whole grains, dried beans, meats, milk, potatoes, beef, coffee, tomatoes, orange juice. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Substance that increases the volume of urine. Can lower blood pressure and deplete body's potassium. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | If kidneys function normally, no Upper Level needed. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Important negative ion for the extracellular fluid Ions are a component of the acid produced in the stomach Used during immune responses |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Caused by low intake, frequent and lengthy bouts of vomiting |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        99% used to strengthen bones and teeth 40% of all minerals present in body Present in all cells Growth and bone development Blood clotting Assists flow of ions in and out of nerve cells Regulates cellular metabolism by influencing the activities of various enzymes and hormonal responses Reduces risk of certain cancers, kidney stones, hypertension, high blood cholesterol, obesity |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Primarily in upper part of the small intestine (most acidic portion). Depends on active vitamin D hormone.
  Enhanced by blood levels of parathyroid hormone, presence of glucose and lactose in the diet, gradual flow of digestive contents through the intestine.
  Limited by large amounts of phytic acid in fiber, great excess of phosphorus in the diet, polyphenols in tea, vitamin D deficiency, diarrhea, old age. |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Decreased bone mass related to the effects of aging, genetic background, and poor diet in both genders, and hormonal changes at menopause in women |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Body condition marked by sharp contraction of muscles and failure to relax afterward
  Usually caused by abnormal calcium metabolism |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Cheese, milk, bread, rolls, crackers, leafy greens, spinach, broccoli, sardines, canned salmon |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | High blood and urinary calcium concentrations, irritability, headache, kidney failure, soft tissue calcification, decreased absorption of other minerals |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Component of enzymes, DNA, cell membranes, (85%) bone |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        70% Active vitamin D enhances |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Milk, cheese, meat, bread, cereal, bran, eggs, nut, fish, baked goods, processed meats, soft drinks |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Found in preterm infants, vegans, alcoholics, older people, long-term diarrhea |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Imbalance in calcium-to-phosphorus balance Hurts kidneys |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Nerve and heart function Enzyme reactions 60% is in bone |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Milk, meats, whole grains, broccoli, potatoes, squash, beans, nuts, seeds, chocolate, tap, coffee |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Irregular heartbeat Weakness Muscle pain Disorientation Seizures |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
         | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        | Found in amino acids, biotin, thiamin, proteins, preservatives |  
          | 
        
        
         | 
        
        
        Term 
         | 
        
        
        Definition 
        
        Helps balance of acids and bases in body Part of liver's drug-detoxifying pathways |  
          | 
        
        
         |