Term
|
Definition
They inhibit the sodium-potassium pump and increase intracellular calcium. This causes the cardiac muscle fibers
to contract better. |
|
|
Term
| What three effects does Glycosides have on the heart: |
|
Definition
1. A positive inotropic action that increases cardiac muscle contraction.
2. Negative chronotropic action that decrease the heart rate.
3. A negative dromotropic action that decreases conduction of the electrical
stimulus. |
|
|
Term
| What is the antidote for Glycosides? |
|
Definition
The antidote for
glycoside toxicity is digoxin immune Fab (Ovine, Digibind). |
|
|
Term
| What are the three groups of Cardiac Drugs? |
|
Definition
| glycosides, antianginals, and antidysthythmics |
|
|
Term
| What does Antianginals Do? |
|
Definition
They are used to treat angina pectoris by increasing
blood flow either by increasing oxygen supply or by decreasing oxygen demand
of the heart. |
|
|
Term
| What are the three antianginal classes? |
|
Definition
| Nitrates, Beta Blockers, and Calcium Channel Blockers |
|
|
Term
|
Definition
They reduce venous tone resulting in decreased workload of the heart and
increased vasodilation. These are used to treat variant angina pectoris. |
|
|
Term
| How do Beta-Blockers work? |
|
Definition
They decrease the workload of the heart and decrease
the heart’s oxygen demands. |
|
|
Term
| How Calcium Channel Blocker work? |
|
Definition
They decrease the workload of the heart and decrease the
heart’s oxygen demands and are used to treat variant angina pectoris. |
|
|
Term
| What are the 5 mechanisms of action for Antidysrhythmics? |
|
Definition
- Block adrenergic stimulation of the heart
2. Depress myocardial excitability and contractility
3. Decrease conduction velocity in cardiac tissue
4. Increase recovery time (repolarization) of the myocardium
5. Suppress automaticity (spontaneous depolarization to initiate beats)
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