Term
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Definition
- Muscarininc Agonist Activator
- Reversibly activates mAChR; on ParsympNS & sweat glands
- Tx: urinary retention; inc bladder emptying
- SE's: Dec HR, Inc sweat, salivation, gastric acid sec, gi motility, bronchoconstriction, vasodilation, miosis
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Term
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Definition
- Muscarinic receptor antagonist
- Reversibly inhibits mAChR by Ach; acts at mAChr w/ therapeutic doses, nAChr at high doses
- Mydriasis eye exams; Inc HR; dec GI motility; OD mAChr agonist
- Inhibition of mAChR; tachycardia, inc urinary retention, constipation; dec sweating, gastric acid; mydriasis;
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Term
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Definition
- Cholinesterase Inhibitor (Cholinergic = M and NM receptors) - Blocks the action of the enzyme that breaks down ACh... allowing ACh to have it's affects longer
- Reversibly inhibits AChE, with tx affecting mAChR's and nAChR's only
- Tx: Myesthenia Gravis, reverses effects of Tubocurarine
- SE's: Excessing mAChR activation, ACh remains in NMJ for too long = respiratory paralysis
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Term
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Definition
- Competative Neuromuscular Blocker (non-depolarizing)
- Competeatively inhibits ACh from binding to Nm receptors, NO CNS effects due to + charge, no access across BBB(thus pain/concious remains)
- Tx: Causes flaccid paralysis, used for mechanical ventilation, endotracheal intubation, surgery
- SE's: Resp. depression, dec. BP, dec. HR - all reversed by AChE inhibitor
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Term
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Definition
- Depolarizing neuromuscular blocker
- Short acting (compared to tubocurarine), binds to Nm, initially activating receptor-causing contraction, does not readily release from Nm, blocking ACh from binding
- Tx: Muscle relaxation (muscle paralysis), used for short procedures (endotracheal intubation, endoscopy
- SE's: malignant hyperthermia, post-op muscle pain, does not cross BBB due to + charge.
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Term
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Definition
- Adrenergic Receptor Agonist
- Sympathetic-acting drug; activates alpha1, alpha2, beta1 and beta2 receptors
- a1 vasoconstriction: dec absorption, bleeding, decongestion; inc BP; b1 restores cardiac funtion; b2 inc bronchodilation
- HTN, angina pectoris, dysrhythmias, hyperglycemia in diabetics
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Term
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Definition
- Alpha1 Adrenergic Receptor Agonist
- dilation of arterioles & veins, relaxation of smooth muscle in bladder
- Tx: HTN; benign prostatic hyperplasia
- SE's: Orthostatic hypotension; reflex tachycardia; nasal congestion
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Term
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Definition
- B1 and B2 adrenergic receptor antagonist
- Competitive antagonist; dec HR, contractility renin (dec CO, BP); inc bronchoconstriction, vasoconstriction, dec glycogenolysis
- Tx: HTN, dysrhythmias, angina, MI
- SE's: Dec HR, bronchoconstriction, glycogenolysis, CAN cross BBB, so CNS is affected
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Term
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Definition
- B1 Adrenergic Receptor Antagonist
- Dec. HR, force of contraction, renin release, AV conduction velocity
- Tx: HTN, angina pectoris
- SE's:Bradycardia, dec CO, AV heartblock, rebound cardiac excitation
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