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| Elimination rate (not constant) is directly proportional to the drug concentration in the plasma. This is considered a non-linear process. Mathematically platting concentration vs. time will give you a straight line. |
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| Elimination rate is independent of drug concentration in the plasma. A set amount of drug is eliminated at each interval. This is a linear process. |
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| Bind to and activate receptor to produce effect |
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| A relationship between the quantity of a certain drug in the body to the concentration (C) of that same drug in the blood or plasma. May be in relation to blood, plasma, or water. Equation: Vd= Amount of drug in the body/C. A high volume of distribution means the drug did not stay in the vasculature but rather dispersed into the extravascular tissue. A low vd is defined when drugs are retained within the vascular space |
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Harm, injury, or unpleasant affect associated with taking medication of normal dose during normal use. Adverse drug reaction (ADR) can happen following a single dose or after prolonged use. It can also occur when using a combination of drugs. ADR is different from “side effect”. ADRs can be classified by 6 types: dose-related (Augmented), non-dose-related (Bizarre), dose-related and time-related (Chronic), time-related (Delayed), withdrawal (End of use), and failure of therapy (Failure) . Adverse effects can be local, or systemic.
Reference: www.ncbi.nlm.nih.gov/pubmed/11062960 |
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| Actions of the drug on the body, including pharmacologic effect and clinical response (effectiveness vs. toxicity). |
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| Governs the absorption, distribution, and elimination of drugs and are of great importance in the choice and administration of a particular drug for a particular patient. |
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| Pharmacotherapy for Advanced Nursing Roles |
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University of Wisconsin
College of Nursing
Graduate Program |
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