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NSAIDs, DMARDs, Analgesia, Asthma and COPD, Histamines
Assessment 6 - block 2
43
Pharmacology
Graduate
09/26/2011

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Cards

Term
COX1/2 inhibitor
Definition
What does ASA work on?
Term
Salicylic acid
Definition
What is ASA metabolized to?
Term
GI
Definition
Biggest side effect of NSAIDs?
Term
ASA
Definition
What drug can cause tinnitus?
Term
Acetominophen
Definition
If someone is pregnant, what drug should be used for peripheral pain relief?
Term
Ketorlac; diclofenac; arthrotec
Definition
What are the heteroaryl acetic acid derivatives?
Term
Ketorlac
Definition
Which of the NSAIDs can be administered parenterally?
Term
Ketorlac
Definition
Which of the NSAIDs is not very useful for long term pain?
Term
Diclofenac and ASA
Definition
Which of the NSAIDs has a transdermal application?
Term
Ibuprofen; naproxen; oxaprozin
Definition
What are the proprionic acid derivatives?
Term
False
Definition
T/F-Acetominophen is a good antiinflammatory.
Term
Longer half life- therefore once daily administration
Definition
What is the advantage of oxaprozin over naproxen
Term
piroxicam; meloxicam
Definition
what are the enolic acid NSAIDs?
Term
less GI side effects and once daily admin
Definition
what is an advantage of meloxicam?
Term
Celebrex
Definition
What is the only selective COX2 still available?
Term
Acetaminophen; indomethacin
Definition
What are the para-aminophenol derivatives?
Term
dihydrofolate reductase and de novo purine biosynthesis
Definition
WHat is the target of methotrexate?
Term
Orally
Definition
How is methotrexate adiministered?
Term
Yes. This allows immunosuppression effects of GC immediately while methotrexate kicks in over the nex few weeks
Definition
Can methotrexate be coadministered with glucocorticoids?
Term
Increased risk of infection
Definition
What is the most serious side effect that all DMARDs have in common?
Term
Leflunomide adn hydroxychloroquine
Definition
What are the 2nd line treatments after methotrexate?
Term
pyrimidine synthesis inhibitor
Definition
What is leflunomide's mechanism of action?
Term
Sulfasalazine
Definition
What DMARD is a prodrug that is converted by colonic bacteria?
Term
false receptor
Definition
MOA of etnaercept
Term
No
Definition
can two TNF inhibitors be used in combination therapy?
Term
Yes
Definition
Can a TNF inhibitor be used with methotrexate or NSAIDs?
Term
RA; psoriatic arthritis; AS; and psoriasis
Definition
what is etanercept used to treat?
Term
RA; psoriatic arthritis; AS; psoriasis; UC; and Crohn's
Definition
what is infliximab used to treat?
Term
RA; psoriatic arthritis; AS; psoriasis; and Crohn's
Definition
What is adalimumab used to treat?
Term
IV
Definition
How is infliximab administered?
Term
SC injection
Definition
how is etanercept administered?
Term
false receptor
Definition
MOA of infliximab
Term
false receptor
Definition
MOA of adalimumab
Term
SC injection
Definition
How is adalimumab administered?
Term
RA; psoriatic arth; and AS
Definition
what is simponi used to treat?
Term
SC injection
Definition
How is simponi administered?
Term
Cimzia
Definition
Which DMARD is conjugated to polyethlene glycol?
Term
SC injection
Definition
How is cimzia administered?
Term
RA and Crohn's
Definition
what does cimzia treat?
Term
IL-1 receptor antagonist
Definition
MOA of anakinra
Term
patients who failed treatment with methotrexate
Definition
Who is anakinra indicated for.
Term
No
Definition
Can anikinra be used with TNF inhibitors?
Term
SC injections
Definition
How is anakinra administered?
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