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Details

NSAIDs
Overview
19
Audiology
4th Grade
10/20/2013

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Cards

Term
Diclofenac (Voltaren)
Definition
Acetic Acid
Term
Indomethacin (Indocin)
Definition
Acetic Acid
Term
Ketorolac (Toradol)
Definition
Acetic Acid
Term
Celcoxib (Celexa)
Definition
COX-2 Specific
Term
Nabumetone Relafen)
Definition
Non-Acidic Agent
Term
Ibuprofen (Motrin, Advil)
Definition
Propionic Acid
Term
Naproxen (Naprosyn, Anaprox, Aleve)
Definition
Propionic Acid
Term
constitutive
Definition
COX-1
Term
inducible
Definition
COX-2
Term
decreased GI complications short term, but not long term; increased cardiovascular risk; possible cross sensitivity with sulfa allergies
Definition
Celecoxib (Celebrex)
Term
avoid in patients with renal failure or in high risk of bleeding; treatment should not exceed 5 days
Definition
Ketorolac (Toradol)
Term
NSAIDs Black Box Warnings
Definition
increased risk of serious CV thrombotic events, MI, stroke; CI for txt of peri-operative pain in the setting of CABG surgery
Term
preferred for the short term before NSAIDs to reduce CV events
Definition
short-acting opioids
Term
preferred NSAID to be used
Definition
Naproxen
Term
used in NSAID patients at increased risk of GI ulceration
Definition
PPI
Term
NSAIDs effect on the afferent arteriole
Definition
constriction
Term
constriction of the afferent arteriole
Definition
decreases renal blood flow leading to renal decompensation
Term
NSAID constriction on the afferent arteriole causes impairment of GFR
Definition
reversible
Term
NSAIDs Pearls
Definition
Synergistic with acetaminophen and/or opioids; Ceiling effect; not recommended in heart failure; use caution with warfarin
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