Term
|
Definition
| blocks synthesis of PGs and TX w/o blocking LT synthesis |
|
|
Term
|
Definition
| fever, tendonitis, sunburn, rheumatoid arthritis |
|
|
Term
| what are NSAIDs ineffective against? |
|
Definition
| sharp pain assoc w/mechanical stimulation of pain fibers |
|
|
Term
|
Definition
|
|
Term
| side effect of aspirin on kidney |
|
Definition
| oliguria, fluid retention, decreased sodium excretion and renal failure. |
|
|
Term
| active agent inhibiting COX |
|
Definition
|
|
Term
| this changes potency on salicylics |
|
Definition
| substitution on OH group or benzene ring |
|
|
Term
| what is asprin hydrolyzed to in the plasma |
|
Definition
| acetic acid and salicylate(longer half life) |
|
|
Term
| effect of Vd on salicylates |
|
Definition
| drop in pH doubles amount available |
|
|
Term
| what is salicylates contra'd in |
|
Definition
|
|
Term
| adverse effects of salicylates |
|
Definition
**tinnitus**
hyperventilation and respiratory alkalosi |
|
|
Term
| moderate intoxication via salicylates cause |
|
Definition
increase in metabolic rate
respiratory acidosis
metabolic acidosis
**most observed in children and infants** |
|
|
Term
| treatment of salicylate treatment |
|
Definition
emesis or gastric lavage
alkalinize the urine
hemodialysis
diazepam |
|
|
Term
|
Definition
hemophilia, pregnancy or hypersensitivity
SLE, Reye's syndrome |
|
|
Term
| low dose of ibuprofen/high dose |
|
Definition
analgesic
anti-inflammatory |
|
|
Term
| serious side effects of ibuprofen |
|
Definition
| agranulocytosis, aplastic anemia, renal failure |
|
|
Term
|
Definition
|
|
Term
|
Definition
most potent inhib of prostaglandin synthesis.
DOC for patent ductus arteriosus
used also in gouty arthritis, spondylitis |
|
|
Term
|
Definition
short term mgmt of acute pain and inflammation.
used in comb w/opiate |
|
|
Term
|
Definition
partial Cox 2 inhib
20hr half life
osteo and rh arthritis |
|
|
Term
|
Definition
Cox 2 inhib
dysmenorrhea, arthritis |
|
|
Term
| side effects of celecoxib |
|
Definition
elevated blood pressure
inhibition of PGI synthesis (risk of heart attack) |
|
|
Term
| how does colcichine treat gout |
|
Definition
| inhibiting neutrophil activation |
|
|
Term
| 2 ways of normalizing gout |
|
Definition
increasing uric acid elimination
inhibiting synthesis of uric acid |
|
|
Term
| these drugs inhibit urate reabsorption and increase excretion |
|
Definition
| Probenecid and sulfinpyrazone |
|
|
Term
| allopurinol mech of action |
|
Definition
| inhibits xanthine oxidase |
|
|
