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NSAIDS and Steroids
NSAIDS, Acetaminophen, Steroids General
14
Pharmacology
Graduate
10/25/2009

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Cards

Term
Aspirin
Definition
irreversible, antipyretic, anti-inflammatory, analgetic
Term
Sodium Salicylate
Definition
aspirin class, same action
Term
Mesalamine
Definition
asprinim class, same action
Term
Ibuprofen
Definition
non-salicylic class, same action, COX
Term
Naproxen
Definition
non-salicylic class, same action, COX
Term
Diclofenac
Definition
LT, COX, anti-inflammatory more
Term
Ketorolac
Definition
LT, COX, analgesic more
Term
Piroxicam
Definition
COX 1 > 2, anti-inflammatory more, more potent (w/Inndomethacin)
Term
Meloxicam
Definition
COX 2 > 1, anti/all 3
Term
Indomethacin
Definition
PLA 2, COX 1, PMN migration, T/B proliferation, more potent antiinflammation than aspirin, but not used much b/c toxicity
Term
Celecoxib
Definition
COX 2, anti-inflammatory selectivity, less SE, RA/OsteoArthritis treatment
Term
Acetaminophen
Definition
COX inhibition in CNS, Liver toxicity
Term
Steroid AI
Definition
PLA 2, COX 2, early + late phase (leukocytes, M?); complement; STRONG – cellular immunity inhibition; WEAKER – humoral; Synthetic Analog preferred (less Na retained); Prolonged therapy – toxicity; Abrupt cessation – adrenal insufficiency
Term
Dexamethasone
Definition
Diagnose of Cushing Syndrome, Level of Cortisol reduced if present; DD of Depressive psychiatric states
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