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ns4410 quiz 1
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4
Accounting
Kindergarten
09/12/2013

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Term
what does hormone sensitive lipase do?
Definition

helps release free FA into the blood stream.

(Normally HSL would be inhibited by insulin but because intra-abdominal fat is insulin resistant, HSL is not inhibited hence release of NEFA’s.)

Term
what does excessive delivery of NEFA’s to liver result in?
Definition
fatty liver, dyslipidemia and IR.
Term
how do NEFA’s contribute to insulin resistance?
Definition

excess VAT is IR which makes them more LIPOLYTICALLY active--> increasing release of free FA into the blood. Leading to:

·      IR in LIVER AND MUSCLE cells

·      influences insulin secretion by beta-pancreatic cells

·      promote vasoconstriciton.

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