Term
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Definition
- required for transpor tof lipid in the blood
- maintains solubility
- composed of pro, PL, chol, & TAG
- classified according to density |
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Term
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Definition
- protein components
- provide stability
- distinquish bw LP |
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Term
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Definition
- packaged in golgi
- LP formed after meal in mucosal cell of SI
- rich in TAG, enter blood via lymph |
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Term
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Definition
| - catalyzes hydrolysis of chylomicra TA to allow for cellular uptake |
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Term
| Synthesis of Chylomicrons |
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Definition
- recombining of FA +2MG in SER->TG
- transported in LP; intestinal cells package TG w/pro, PL, CE |
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Term
| Transport of Chylomicrons |
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Definition
- Exocytosis->lymph->blood
- enter blood w/i 1-2hrs post meal
- prevents huge "spike" in BL) |
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Term
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Definition
- LP formed in circulation when TAG is removed from IDL by LPL
- major chol carrying LP
- removed by LDL receptors or processes in other organs
- most atherogenic LP |
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Term
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Definition
- formed in liver, secreted into blood
- transports TG made in liver to other tissues
- contains chol & CE
- converted to LDL in blod by LPL |
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Term
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Definition
- transmembrane glycoprotein w/5 defined domains
- interacts w/apo B-100 & apo-E on surface of LDL (facilitating internalization)
- # of receptros found on cells varies according to chol requirement |
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Term
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Definition
- formed in blood by removal of TG from VLDL
- intermediate density
- little nutritional importance |
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Term
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Definition
- synth & taken up by liver
- promotes reverse cholesterol transport
- LCAT forms CE from free chol
- low levels = risk for CVD |
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Term
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Definition
- activates LPL
- impt in CM & VLDL |
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Term
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Definition
- stimulates receptor-mediated endocytosis of LDL
- impt in CM & VLDL |
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Term
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Definition
- activates LCAT
- impt to allow HDL to reform into VLDL in liver |
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Term
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Definition
-stimulate receptor-mediated endocytosis of HDL
- impt in uptake of LDL by liver |
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Term
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Definition
- largest repository of E in body (TG)
- thermal insulation/temp reg
- protects organs |
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Term
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Definition
- Release of FA from adipose TG
- increased cAMP = phosphorylation of lipases
- complete hydrolysis requires 3 lipases
- free glycerol not used in adipocyte |
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Term
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Definition
| -increased insulin = increased LPL = FA enter cell=FA CoA -> TG(stored) |
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Term
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Definition
- free FA's circulate as complexes
- ionic association w/albumin
- from mobilization of fat stores
- turnover is rapid |
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Term
| Role of adipose tissue im lipid metabolism |
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Definition
- abs TG & chol from CM & VLDL thru LPL
- stores TAG
- adipocytes: lipoylysis, release FA ito blood |
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Term
| Role of liver in lipid metabolism |
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Definition
- synth of bile acids, LP, new lipids from non-lipid precursors
- produces KB, continues to synth VLDL & HDL |
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Term
| transport of LCFA Acetyl CoA into mito |
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Definition
- CPTI: obtained from diet or synth from lys & meth(Vit C)
- inner mito membrane=impermeable
- malonyl CoA inhibits
- each dbl bond present i USFA = 2 fewer ATP produced during oxidation |
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