Pasireotide

Somatostain analog

Cushings disease

Everolimus

 renal angiomyolipoma associated with tuberous sclerosis complex (TSC)

subependymal giant cell astrocytoma (SEGA) associated with TSC

Everolimus

Inhibitor of mammalian target of rapamycin (mTOR) mechanistic target of rapamycin or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1). mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcriptio^n.

Oncology

Letrozole

non-steroidal aromatase inhibitor

hormonally-responsive breast cancer after surgery.

Nilotinib

Tyrosine-kinase inhibitor

CML (first-line-treatment)

Zoledronic acid

bisphosphonate

Prevention of bone fractures in cancer patients

Ocreotid

Somatostatin-Analoga

Acromegaly

ruxolitinib

Ruxolitinib is a Janus kinase inhibitor

Myelofibrosis

Imatinib

competitive tyrosine-kinase inhibitor

CML

Deferasirox

Iron chelator

Chronic iron overload

zoledoronic acid

Bisphosphonate

Osteoporosis

Preparation: Reserpine, Dihydralazine, Hydrochlothiazide

Reserpine: vesicular monamin transport blocker

Dihydralazine: smooth muscle relaxant

Hydrochlorthiazide: Thiazid diurectic

Hypertension

Everolimus

Inhibitor of mammalian target of rapamycin (mTOR) mechanistic target of rapamycin or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1). mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcriptio^n.

Immunosuppressant (renal rejection)

Everolimus

Inhibitor of mammalian target of rapamycin (mTOR) mechanistic target of rapamycin or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1). mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcriptio^n.

Immunosupressant (renal rejection)

Preparation

Alisikren: direct renin inhibitor

Amlodipine : calcium channel blocker

Hydrochlorthiazide: Thiazid Diuretic

Hypertension

Clomipramine

Tricyclic Antidepressant

Major depression, Obsessive-compulsive disorder

Indacaterol

Beta adrenoceptor agonist

COPD

Indacaterol

Beta-Adrenoceptor Agonist

COPD

Clopamide

Thiazid like diuretic

Hypertension

Clozapine

Atypic Antipsychotic

Treatment resisten schizophrenia

Clozapine

Atypic antipsychotic

Treatment resistant schizophrenia

artemether/lumefantrine

Artemisinin based comibination therapy

(mechanism unknown)

Plasmodium falciparum malaria (uncomplicated)

artemether/lumefantrine

Artemisinin based comibination therapy

(mechanism unknown)

Plasmodium falciparum malaria (uncomplicated)

Entacapone

COMT inhibitor (prevents COMT from metabolizing L-DOPA)

Parkinson

Valsartan

AT II receptor antagonist

Hypertension

Preparation

Vildagliptin: inhibits the inactivation of GLP-1and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin

Metformin : suppressing glucose production by the liver

DM II

Preparation

Vildagliptin: inhibits the inactivation of GLP-1and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin

Metformin : suppressing glucose production by the liver

DM II

Rivastigmine:

parasympathomimetic or cholinergic agent

Alzheimer

Preparation

Amlodipin

Valsartan

Hypertension

Famciclovir

guanosine analogue

Herpes infections

Iloperidone

atypical antipsychotic

schizophrenia

dexmethylphenidate

norepinephrine-dopamine reuptake inhibitor (NDRI)

ADHD

Formoterol

long acting β2-Agonist

Asthma, COPD

Vildagliptin

DDP4 Inhibitor

DM II

Fingolimod

immunmodulating drug

Fingolimod is a sphingosine 1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction.

MS

Chlortalidone

Thiazid diuretic

Hypertension

Canakinumab

monoclonal antibody targeted at interleukin-1 beta.

Cryopyrin-associated periodic syndrome (CAPS)

a spectrum of autoinflammatory syndromes

Terbinafine hydrochloride

Inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway.

Fungal infections

Fluvastatin

HMG-CoA reductase inhibitor

Hypercholesterolemia

Baclofen

GABA derivate

Spasticity

Amlodipine

Benazepril: ACE-inhibitor

Hypertension

Ranibizumab

monoclonal antibody fragment

Age related macula degeneration

maprotiline

tetracyclic antidepressant

major depressive disorder

thioridiazin

antipschotic

schizphrenia

Mycophenolic acid

 immunosuppressant:  the growth of T cells and B cells.

Prevention of transplant rejection

Tropisetron

5HT3 Receptor antagonist

Chemotherapy induced nausea and vomiting

Methyphenidate

norepinephrine-dopamine reuptake inhibitor

ADHD

Ciclosporine

Immunosuppressant

Transplant

Ciclosporin

Immunosuppressant

Transplant

Basiliximab

monoclonal antibody to the IL-2 receptor of T cells

Transplant rejection

Tizanidine

Muscle relaxant/ alpha2 adrenergic agonist

Spasticity

Preparation

Antazoline : Antihistamine

Tetrahydrozoline: Alpha Agonist

Allergic conjuctivitis

Preparation

Carbidopa: inhibits aromatic-L-amino-acid decarboxylase  an enzyme important  in the biosynthesis of L-DOPA to Dopamine (DA).

Levodopa: precurser of dopamine

Entacapone: catechol-O-methyl transferase (COMT) inhibitor.

Parkinson

Carbamazepine

Anticonvulsant, mood-stabilizer

Epilepsy, bipolar disorder

Preparation

Aliskiren, Amlodipine

Hypertension

Aliskiren

Hypertension

Aliskiren

Hypertension

Tobramycin

Aminoglycoside

Prevention of Pseudomonas aeruginosa infection in cystic fibrosis

Imipramine

Tricyclic antidepressant

major depression, enuresis, panic disorder

Oxcarbazepine

Anticonvulsant, mood stabilizer

Epilepsy, bipolar disorder

Telbivudine 

antiviral drug (thymidine nucleoside analogue)

Hep B

Telbivudine

 antiviral drug7

HepB

Verteporfin

photosensitizer for photodynamic therapy

wet form of macula degeneration

Omalizumab

humanized antibody : binds to IgE

Asthma (severe)

Ketotifen

Antihistamine, mast stabilizer

Asthma, allergic conjuctivitis