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Norovirus
ONU med micro r-anderson
16
Microbiology
Undergraduate 2
10/20/2011

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Term
adult version of...
Definition
rotavirus
Term
etiology
Definition
ssRNA, polyhedral capsid, nonevnveloped
Term
reservoir
Definition
infected humans
Term
transmission
Definition
common vehicle - food or water
contact - direct, fomites, droplets (aersolization of vomit)
Term
ID50
Definition
10
Term
entry
Definition
pharynx - fecal contamination
Term
attachment
Definition
capsid protein attaches to receptor on small intestine epithelium
Term
avoid host defenses
Definition
intracellular pathogen, protected environment
Term
damage
Definition
cell lysis
inflammation response
Term
exit
Definition
feces/vomit
Term
clinical presentation
Definition
incubation period 24-48 hours
vomiting, diarrhea, cramps, nausea
fever
dehydration
symptoms last 24-60 hours
Term
diagnosis
Definition
not typically done
specimen: feces
Test: reverse transcriptase polymerase chain reaction
Term
treatment
Definition
no antiviral therapy
fluids and electrolytes
Term
personal prevention
Definition
strict handwashing after using bathroom and before handling food
disinfection of surfaces
isolation of ill
Term
community prevention
Definition
food and water protection
can survive up to 10ppm chlorine
Term
immunity
Definition
strain specific and may only last a few months
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