Term
| why is acetominophen no longer part of the NSAIDs? |
|
Definition
| it has no anti-inflammatory properties |
|
|
Term
| the ______ phase of the inflammatory response is characterized by increased capillary permeability |
|
Definition
|
|
Term
| the _______phase of the inflammatory response is characterized by infiltration of leukocytes and phagocytice cells |
|
Definition
|
|
Term
| what is the chronic proliferative phase of the inflammatory response characterized by? |
|
Definition
| tissue degeneration and fibrosis |
|
|
Term
| a defense reaction caused by tissue damage or injury |
|
Definition
|
|
Term
| what is inflammation characterized by? |
|
Definition
| heat, redness, swelling, pain, and loss of function |
|
|
Term
| What are the major enzymes inhibited by NSAIDs? |
|
Definition
|
|
Term
| the most relevant mediators of inflammation are ___________. |
|
Definition
| arachidonic acid metabolites |
|
|
Term
| name some mediators of inflammation: |
|
Definition
| vasoactive amines, platelet activating factor, complement system, kinin system, cytokines, nitric oxide, adhesion molecules, arachidonic acid metabolites |
|
|
Term
| Which cox enzyme is always present? |
|
Definition
|
|
Term
| which cox enzyme is induced by a stimulus? |
|
Definition
|
|
Term
| What are some physiological regulations of COX-1 |
|
Definition
| GI, protection, platelet function, regulation of blood flow, kidney function |
|
|
Term
| what is the inflammatory response by newly expressed COX-2 |
|
Definition
| inflammation, pain, fever |
|
|
Term
| how do prostaglandins cause inflammation? |
|
Definition
| vasodilation and opening of the endothelial cells that allow inflammatory cells to move from the blood stream to the site of injury. |
|
|
Term
| blocking prostaglandin production may cause |
|
Definition
| increased acid production and decreased mucous production |
|
|
Term
| NSAIDs lack the unwanted side effects of the________ |
|
Definition
|
|
Term
| how do NSAIDs reduce fever? |
|
Definition
| by blocking the production of prostaglandins. |
|
|
Term
| an emerging use for NSAIDs is the in the prevention of _________ and __________ |
|
Definition
| colon cancer and cardiovascular disease |
|
|
Term
| salicylates, propionic acid derviatives, enolic acids, arylacetic acid derivatives, selective COX-2 inhibitors |
|
Definition
|
|
Term
| most widely used and prescribbed analgesic-antipyretic-anti-inflammatory drug |
|
Definition
| Aspirin- (Salicylate)- acetylsalicylic acid |
|
|
Term
| _______ are highly bound to the plasma protein albumin. Thus, they will have interactions with other medications leading to higher free drug levels |
|
Definition
|
|
Term
| mild intoxication as a result of repeated high doses intake of aspirin |
|
Definition
|
|
Term
| The main side effect of salicylates is |
|
Definition
| gastric irritation because of decreased mucous and increased aspirin |
|
|
Term
| is the induction of asthma attack with asprin an immune response? |
|
Definition
| No, treat this with an antihistamine |
|
|
Term
| in children, this is characterized by the acute onset of encephalopathy, liver dysfunction, and fatty infiltration of the liver and other viscera |
|
Definition
|
|
Term
| irreversibly modifies both Cox-1 and Cox-2 by acetylating serine-530 in the active site. |
|
Definition
| Mechanism of action of aspirin |
|
|
Term
| Aspirin is metabolized by_________ |
|
Definition
|
|
Term
| an enzymatic reaction that can be saturated |
|
Definition
|
|
Term
|
Definition
| propionic acid derivative |
|
|
Term
| arylacetic acid derivative prescribed for rheumatoid arthritis and other types of arthriis. toxicity limits its use |
|
Definition
|
|
Term
| this arylacetic acid derivative is used as in IM injection in the ER because its effects are very close to that of the opiods |
|
Definition
|
|
Term
| this enolic acid can be better toleratend than aspirin or indomethacin and its advantage is its long half life |
|
Definition
|
|
Term
| most NSAIDs can increase the anticoagulant effect of ______ |
|
Definition
|
|
Term
| potentially all NSAIDs can blunt the actions of these diuretics |
|
Definition
|
|
Term
| Specific COX-2 inhibitors |
|
Definition
celecoxib
refecoxib
valdecoxib |
|
|
Term
| this drug is a well tolerated analgesic and an antipyretic it lacks many of the side-effects of aspirin and other NSAIDs |
|
Definition
|
|
Term
| what can happen in an overdose of acetopminophen? |
|
Definition
| hepatic and renal necrosis- failure of both organs- death |
|
|
Term
| what do you administer in an acetominophen overdose? |
|
Definition
|
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