Term
|
Definition
aka acetylsalicylic acid
Salicylate |
|
|
Term
|
Definition
aka Votaren XR
Nonselective NSAID |
|
|
Term
|
Definition
aka Advil, Motrin IB
Nonselective NSAID |
|
|
Term
|
Definition
aka Toradol (Canada)
Nonselective NSAID |
|
|
Term
|
Definition
aka Aleve, Naprosyn
Nonselective NSAID |
|
|
Term
|
Definition
aka Celebrex
Selective NSAID |
|
|
Term
|
Definition
aka Tylenol, paracetamol (in other countries), Ofirmev (IV)
miscellaneous |
|
|
Term
|
Definition
natural product
contains salicylate |
|
|
Term
|
Definition
aka Acetadote
administered IV
antidote for acetaminophen |
|
|
Term
|
Definition
| drug that interferes with the clotting cascade - does not dissolve clots, just keeps them from forming |
|
|
Term
| antiplatelet drug/platelet inhibitor |
|
Definition
| suppresses platelet activation and aggregation |
|
|
Term
|
Definition
| antiplatelet drug or anticoagulant (misleading) |
|
|
Term
|
Definition
| drug that actually dissolves clots |
|
|
Term
| Mechanism of action: aspirin |
|
Definition
decrease PG synthesis by inhibiting COX 1 & 2 irreversibly
affects peripheral and central (CNS) |
|
|
Term
| Mechanism of action: acetaminophen |
|
Definition
decrease PG synthesis by inhibiting COX 1 & 2 weakly in the CNS
decrease PG synthesis by inhibiting COX 3 strongly in the CNS |
|
|
Term
| Mechanism of action: nonselective NSADS |
|
Definition
decrease PG synthesis by inhibiting COX 1 & 2, reversibly
peripherally and centrally |
|
|
Term
| mechanism of action: selective NSAIDS |
|
Definition
decrease PG synthesis by inhibiting primarily COX 2, reversibly
peripherally and centrally |
|
|
Term
| which nonopioid analgesic is not high protein binding? |
|
Definition
|
|
Term
| what are the absorption issues for nonopioid analgesics? |
|
Definition
| no major issues - may take with food if desired |
|
|
Term
| how does ibuprofen affect fetus/neonates? |
|
Definition
| not detected in breastmilk in significant amounts, but crosses placenta |
|
|
Term
| at what point should pregnant women change their NSAID use? |
|
Definition
| Avoid NSAIDs in the second half of pregnancy |
|
|
Term
| where are the nonopioid analgesics metabolized |
|
Definition
|
|
Term
| when is a person at risk for analgesic nephropathy? |
|
Definition
| with chronic high-dose NSAID/acetaminophen use |
|
|
Term
| how are nonopioid analgesics excreted |
|
Definition
| renally, some of the excretion is of active drug |
|
|
