Term
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Definition
-Competitive agonst at Nicotinic receptors (NM jxn)
Non depolarizing NM blocker |
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Term
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Definition
-Fine movements
-Limbs
-Trunk
-Intercostals
-Diaphragm |
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Term
| Non-depolarizing NM blockers |
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Definition
| -Block Ach binding to nicotinic receptors and NM jxn |
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Term
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Definition
Get decreased BP
Get more w/ d-TP than with pancuronium than with atracurium and vecuronium |
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Term
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Definition
Non-depolarizing NM blocker
-Long Half-life
-Not good for renal failure (real long half-life) |
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Term
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Definition
Non-depolarizing NM blocker
-Intermediate duration of action |
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Term
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Definition
Non-depolarizing NM jxn
-Spontaneous breakdown (hoffman elimination)
-Good for elderly and decreased Renal Fxn (because doesn't need to be cleared) |
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Term
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Definition
Non-depolarizing NM blocker
-Cleared by plasma esterases (taken off market) |
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Term
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Definition
-Shortest time of onset and short duration of action
Two phases of Block
1) Endplate is depolarized (cholinesterase inhib intensify block)
2)Partially repolarized (cholinesterase inhib partially reverse block) |
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Term
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Definition
Depolarizing NM blocker
-Myalgia
-K+ release (arrhythmias)
-BEWARE with Burn patients
-If they have atypical pseudocholinesterase, get prolonged paralysis
-Malignant hyperthermia |
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Term
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Definition
GABA agonist (Skeletal muscle relaxant)
Tx: Spasticity w/ MS/spinal cord injury, trigeminal neuralgia |
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Term
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Definition
Inhibits Ca++ release from SR in skeletal muscle
Tx: treatment of malignant hyperthermia |
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Term
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Definition
-Depolarizing NM blocker
-Dont use with cholinesterase inhibitors (can't predict) |
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