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Nm 617
Ante exam 1
35
Other
Graduate
04/13/2014

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Term
Sensitivity
Definition
Proportion of + screens among those known to have the condition of interest.
Term
Specificity
Definition
Proportion of negative screens among those known not to have the condition
Term
Positive predictive value
Definition
True positives among all positive screens
Term
Negative predictive value
Definition
Tue negative among those with negative screens
Term
Absolute risk vs relative risk
Definition
Absolute risk=probability that an event will occur (rate of uterine rupture for VBAC pt is 2 per 1000 or 0.2%)
Relative risk=estimate of the probability of an adverse event in one group relative to another group. I.e. Risk of rupture after csection is 2/1000 vs .06 per 1000 without prior csection - increase of 37 fold
Term
How use of both absolute and relative risk can influence woman's perception of risk
Definition
Telling a women her risk of uterine rupture is increased 37 fold is much different than saying that her risk is less than 1% (0.2%). Health care providers can convey their own perceptions in how they present risk
Term
Informed compliance
Definition
This term refers to communication patterns about medical risk that are biased to influence women's decisions. Example: woman is given handout about quad screen, told this is done at 16weeks and told to ask care provider any questions. This is informed compliance not informed consent
Term
Illusion of choice
Definition
How provider gives info can be framed toward offering a superior choice over another to avoid perceived risks. Example: pt is told her baby is "big" and is offered an induction to avoid problems related to suspected macrosomia. Possible fetal risks are not quantified and risks of labor induction are not discussed, nor is the possibility that no harm may occur by waiting
Term
Concept of language as "control"
Definition
Shifts focus from woman
Pregnancy as a diagnosis- confirmed by professional not woman
Seeing fetus on US:separation
Labor as diagnosis "false labor vs real labor"
Rushed delivery of placenta
Presenting the baby to mom
Term
Predictive value
Definition
See: positive and negative predictive values

Predictive values are very dependent on the prevalence of the condition in the population being screened
Term
Calculate gravida and para using 5 digit system
Definition
Gravida=number of pregnancies
Para=births over 20 weeks, multiples are counted as one birth event
Term
Preterm
Abortion (spontaneous or induced less than 20weeks)
Living children
Term
Contraindications to exercise in pregnancy
Definition
Absolute contraindications according to ACOG
Hemodynamically significant heart disease
Restrictive lung disease
Incompetent cervix
Multiple gestation
Premature labor in present pregnancy
Ruptured membranes
Preeclampsia or PIH
Persistent second or third trimester bleeding
Placenta previa
Term
Immunizations to avoid in pregnancy
Definition
HPV- finish series after pregnancy if already started
LAIV- live attenuated inhaled influenza vaccine
MMR- live virus vaccine
Varicella- live attenuated
Zoster- live attenuated
BCG-not enough studies
Term
Vaccines that are recommended in pregnancy
Definition
Hep A- if otherwise indicated only
Hep B- in some circumstances
Influenza- *recommended for all preg women in flu season
Td- if otherwise indicated. If not previously vaccinated she will need a 3 dose series with one of the shots replaced with Tdap in the 27-36 week time frame
Tdap- recommended once each pregnancy between 27-36 weeks regardless of history of receiving Tdap
Meningococcal- ok if otherwise indicated
Polio- ok if needed only
Anthrax- only if high risk of exposure. Not recommended if Low-risk of exposure
Rabies- ok if otherwise indicated
Smallpox- recommended post-exposure only. Pre-exposure not recommended
Yellow fever- May be used if benefit outweighs risk
Term
Other vaccines: inadequate data
Definition
Inadequate data exists for PCV13, PPSV23, Japanese encephalitis, typhoid
Term
When is Hep B vaccine recommended in pregnancy?
Definition
Hep b vaccine is recommended for women identified as being at risk for HBV infection in pregnancy- more than one sex partner in past 6 months, evaluated or treated for std, recent or current IV drug use, or HBsAg positive sexual partner.
Term
Components of first prenatal visit: history and screenings
Definition

Begin to establish relationship with woman

Comprehensive health history: primary care, medical and surgical, family history, family and personal genetic history for both partners, menstrual, obstetric and gyn histories, sexual history, history of contraceptive use and safety. 

Depression screening and intimate partner violence screeening, immunization screening

Risk history- substance abuse, environmental exposures, other potential harms

Also: symptoms of pregnancy, women's concerns, acceptance of pregnancy 

 

Term
First Prenantal Visit- Education and Guidance
Definition

Topics- stopping all harmful substances (tobacco, alcohol, drugs, teratogens such as medications and occupational exposures)

Seatbelt use, travel, dental care, employment or education plans, appropriate exercise and activity, hot tub/sauna use, nutrition, vaccines, over-the-counter meds.

Anticipatory guidance: fetal growth, common discomforts, pregnancy related changes with related appropriate treatments, mood changes. 

Orientation to midwifery care, schedule of visits, when to call midwife, food safety, options for genetic/chromosomal anomaly screening, toxoplasmosis, sexuality, myths/superstitions, breast support, establishing EDD, weight gain guidelines, pica, perineal and vaginal care 

 

Term
First Prenatal Visit- Physical exam components
Definition

Height and weight

Vital signs

Complete physical with pelvic exam and clinical pelvimetry

Assessent of uterine size/gestational age/compare with LMP

Term
Relevant history, physical, lab and risk assessment data for each trimester: First trimester
Definition

Labs: Review results for initial visit (blood type, antibody screen, RH. hbg/hct or CBC to include PLC, HepBsAg, chlamydia with or without gonorrhea, syphilis (rpr/vdrl), rubella titer, pap, UA and culture, offer cystic fibrosis testing-- possibly lead level, hemoglobin electrophoresis, diabetes screening, free beta hCG).

 

?nuchal tranlucency, PAPP-A, free beta hCG, CVS

 

Physical: weight, blood pressure, fhr with doppler after 8 weeks, assess uterine size and change from previous visit

 

Screenings: Interval history, risk assessment, woman's concerns. Review medications, any symptoms, travel... 

 

 

Term
Relevant history, physical, lab and risk assessment data for each trimester: Second trimester
Definition

Labs: Follow-up on previous results, amniocentesis after 15 weeks if indicated, Quad screening or multiple markers (15-20weeks), Anatomy US (18-20weeks). 

 

Physical: weight, blood pressure, Abdominal exam (fundus halfway to umbilicus at 16 weeks, 2 fungerbreaths below umbilicus at 18 weeks, immediately below umbilicus at 20 weeks, over 20 weeks fundaus should equal weeks gestation +/- 2-3cm). FHR with doppler.

 

Screenings: Risk assessment, woman's symptoms and concerns need to add specifics re:risk assesment for each trimester

Term
Relevant history, physical, lab and risk assessment data for each trimester: Third trimester
Definition

Labs: Gest diabetes screening (24-28weeks), hbg/hct 28weeks, ?repeat antibody screen if Rh negative- prepare to give Rhogam. Follow up on prev. results. ? repeat STI testing as per state law or history. Group B test at 35-37weeks unless unnessary based on history). 

 

Physical: Weight, blood pressure, OB Abd. exam (fundal height), fetal lie and presentation, Leopolds 35-40 weeks for fetal lie, presentation, position, variety, and EFW. FHR. SVE for bishop score if over 40 weeks. AFI, nonstress test, BPP over 40weeks if indicated

 

Screenings: Risk, woman's concerns. Fetal kick counts if high-risk at 28 weeks/start at 35 weeks for all/ Depression screen, intimate partner violence screen. 

Term
Benefits of exercise in pregnancy
Definition

increased energy

Improved sleep

help with weight control

increased strength and endurance

greater sense of wellbeing

fewer back aches

decreased risk of pre-e

possible decreased risk for gest diabetes

may help control blood sugar in combination with diet for women with gest diabetes when diet alone if ineffective. p>?may have significantly shorter second stage of labor but no overall decrease in labor length has been found 

Contradictary evidence re: exercise and vag vs csection and exercise effect on prenatal weight gain

Term

Anticipatory Guidence:Exercise in Pregnancy

 

Definition

Women may start or maintain exercise programs at moderate or vigorous intensities in preg without adverse fetal effects. Use talk test to determine intensityp>

 

Women who are sedentary will benefit from adding exercise to their routines. Advising an increase in activity via daily walking, pregnancy exercise class etc is part of optimal prenatal care. Pregnancy can be a major motivator to make positive health changes 

30 minutes daily of Moderate activity equivalent to brisk walking is recommended
Term
Physiologic changes of pregnancy that impact exercise ability/tolerance
Definition

Women will feel short of breath sooner in pregnancy- due to progesterone effects. Reassure that this is normal 

 

Advise warm up and cool down periods with each exercise session-- musculoskeletal changes may predipose women to injury

 

Avoid supine positions sexism and third trimesters. Pregnancy does not increase risk of hyperthermia with exercise Avoid activities that have high potential for and trauma, falling, twisting of joints suddenly. Nausea, wt gain and fatigue may cause women to need to change expectations re: exercise p>add more here?

Term
More commonly used medication in pregnancy that appear to be safe: GI issues
Definition

N/V- antihistamines (Benadryl, doxylamine (unisom), doxylamine/pyridoxine (Diclegis). Phenothiazines (compazine, phenergan). Benzamides (Metoclopramide- Reglan), Serotonin agonists (Ondansetron). 

 

Acid reflux- antacids- Aluminum/mag hydroxide (rolaids, maalox) and calcium carb (tums). These agents are preferred.

 

Mucosal protectants- Sucralfate (Carafate)

 

H2 antagonists (Cimetidine (tagamet), famotidine (pepcid), nizatidine (axid), ranitidine (zantac). Zantac is preferred agent

 

PPIs-esomeprazole (nexium), omeprazole (prilosec, lansoprazole (prevacid), pantaprazole (protonix), rabeprazole (aciphex): increased risk of hypospadias has been reported

Term
More commonly used medication in pregnancy that appear to be safe: diarrhea/constipation
Definition

Diarrhea: Antidiarrheals: Alosetron (lotronex), diphenoxylate/atropine (lomotil), loperamide (imodium). Alosetron only for IBS-related diarrhea who have failed conventional treatment

 

Constipation: osmotic laxatives: lactulose (Enulose), Mag citrate (Citroma), PEG (MiraLax)

Stimulant laxatives- Bisacodyl (Correctol), Senna-- for short term use only for these agents

Stool softener- Docusate- Colace (short term also)

Term
Medications to avoid in pregnancy
Definition

MEDS to AVOID in pregnancy: Caution esp in first trimester when organogenesis occurs

From Pharmacolgy for Women’s Health 1047-1048

Warfarin

Isotretinion

Valporic acid

Tetracycline

Lithium

DES

Biazin

Erythromycin estolate (Ilosom)

Ergot alkaloids (abortifacients)

Aminoglycosides

Amiodarone

Androgenis steroids

ACE Inhibitors

ARBs

Antithyroid drugs

SSRI- Paxil

Statins

Benzodiazepines

Tegretol

Aspirin- low doses (81mg/daily) appear to be ok- higher doses may cause prolonged gestation, prolonged labor, bleeding probs in neonate, IUGR, perinatal mortality

Iodine

Lindane (Kwell)

Methotrexate

Misoprostol (unless used to induce labor/ripen cervix as off label use)

Mifepristone

Dilantin

Cyclophosphamide

NSAIDs- AVOID ESP first and third trimesters

(increase risk of miscarriage, also risk of premature closure of ductus arteriosus esp third trimester, fetal renal toxicity, inhibition of labor)

Magnesium trisilicate (gaviscon): increase risk of fetal nephrolithiasis.

Sodium bicarb (Neut): metabolic acidosis and fluid overload

Bismuth subsalicylate (peptobismol, kaopectate): salicylate moiety can cause increased perinatal mortality

Thalidomide

Valproic acid

Vitamin A- over 8000IU/day. deficiencies may also cause malformations


Term
Centering Pregnancy: theorectical basis, how it works, how this empowers women. Also benefits and limitations
Definition

Theorectical basis: based on feminist theory, midwifery model of care, social support theory, adult learnign theory and social cognitive theory

 

Comprehensive care in a group setting. melds midwifery philosophy of care with empowering women

 

How it works: takes advantage of fact that women in preg are open to learning and want to share concerns, reactions and experiences. involves self-care activities, faciliator leadership style, includes overall plan and core content each session, stables group composition, provides social opportunity, ongoing eval of outcomes. 10 2-hour sessions, similar due dates. includes education and prenatal care. includes focused physical assessment by provider, group size 8-12 women, meet in a circle. family involvement optional. meet monthly than every 2 weeks and then weekly as per traditional prenatal schedule

 

How this empowers women: shift in relationship so that women take on the decision-making power re:topics discussed and for self-care. individual contribution of each memeber is valued. self-care activities (wt, bp, self-assessment of learning needs). consumer as equal partner. Woman as expert on her own needs

 

Benefits: increased attendance at care, increased preg-related knowledge and increase satisfaction with care. builds community, increased birth weights for infants

Limitatons: resistance to change, need to recruit women, changes scheduling for careproviders/women

Term
More commonly used medications in pregnancy that are safe
Definition

Tylenol, opiates, flexeril

analgesic creams- mentholated or capsacin

 

Allergies and colds: frist generation antihistamines: Chlorpheniramine (Chlortrimeton) first choice; also benadryl, triprolidine, doxylamine. Zyrtec most studied second generation. 

Oral decongestants: pseudoephedrine ok after first trimester (increase risk of gastroschisis in first tri)

Nasal decongestants: Afrin, phenylephrine, xylometazoline all ok. Saline nasal spray ok

 

Nasal corticosteriods- budesomide, becamethasome, and intranasal cromolyn sodium 

 

Antibiotics: PCN, EES, Augmentin, amox, cefizol, ceftin. Zithromax, macrobid, rocephine, third generation cephalosporin + macrolide for pneumonia

 

Antifungals- topical for yeast=butoconazol, clotrimazole, miconazole, terconazole, nystatin, Avoid diflucan in firt trimester. Metronidazole (flagyl) ok. 

 

Dental care: lidocaine and xylocaine ok, xrays ok (would need 5000 dental xrays to exceed safe radiation dose), PCN, augmentin, amox, cleocin all ok. 

Term
hCG levels
Definition
3-4 weeks 150-1000mIU/mL US: decidual thickening
4-5weeks >1000-2000mIU/mL US: gest sac visible tvus at 1000
5-6weeks 1000-7200mIU/mL, yolk sac present when gest sac >10mm. Embryo present if gets sac> 18mm. Cardiac activity present when crown rump >5mm
6-7weeks >10,800mIU/mL; crown rump 4-9mm
Term
Presumptive signs of pregnancy
Definition
Woman experience/reports:
N/V
Cessation of menses in women with prev regular cycles
Tingling, tightness, increased nodularity +\- enlargement of breast or nipples
Urinary frequency
Fatigue
Sustained increased basal body temp
Skin pigment changes
Term
Probable signs of pregnancy
Definition
Physical exam or lab test:
Breast changes- colostrum, enlargement of breasts/nipples
Skin changes- striae, chloasma, linea nigera
Enlarges abdomen, enlarged uterus
Palpable fetal outline
Ballottement
Piskacek's sign
Hegar, goodell, Chadwick signs
Palpation of Braxton hicks
Positive preg test
Positive fetal movement- palpable
Term
Positive signs of pregnancy
Definition
Sonogram
Audible fetal heart rate
Term
More on hCG
Definition
Detectable at 8-10 days after ovulation- coincides with implantation of fertilized egg.
Doubles every 48-72 hours in 85% of normal preg and continues to do so until peak at 100,000 mIU/mL then slowly decrease to stable level of 20,000
Serial levels are useful but 48hours may not be enough to see doubling due to individual differences
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