Term
|
Definition
inhibits FA oxidation to enhance FA to glucose so less O2 is needed
*used in chronic angina* |
|
|
Term
|
Definition
| prolongation of the QT interval |
|
|
Term
| Has substantial vasodilator activity in nitroglycerin |
|
Definition
|
|
Term
| Which relax at lower concentration? arteries or veins? |
|
Definition
| veins- release NO more efficiently |
|
|
Term
| Which relax at lower concentration? arteries, or arterioles |
|
Definition
|
|
Term
| therapeutics of stable angina w/nitros, isosorbid |
|
Definition
|
|
Term
| Sustained stable angina treatment |
|
Definition
oral nitro or iso/mono
transdermal nitro |
|
|
Term
| Treatment of variant angina |
|
Definition
| Nitro plus Ca chan blocker- relieving coronary artery spasm |
|
|
Term
| Unstable angina treatment |
|
Definition
nitroglycerin plus aspirin (platelet inhib) plus Ca chan blocker
decrease O2 demand and dilating epicardial coronary arteries |
|
|
Term
| What is the effect of systemic venodilation |
|
Definition
decrease preload
decreased right vent size
decrease end-diastolic pressure |
|
|
Term
| what is the effect of decreased arterial pressure? |
|
Definition
|
|
Term
| what is the effect of epicardial coronaries? |
|
Definition
|
|
Term
| What effects do nitrates play in MI's? |
|
Definition
|
|
Term
| effects of nitrates on CHF |
|
Definition
reduction of ventricular filling pressure
also preload |
|
|
Term
|
Definition
excessive vasodilation
*caution w/incr cranial pressure* |
|
|
Term
|
Definition
hypertensive emergencies- short term reduction of cardiac pre/afterload
controlled hypotension during anesthesia (b-blocker helps with heart rate) |
|
|
Term
| PCKN of sodium nitroprusside |
|
Definition
| unstable and decomposes when exposed to light |
|
|
Term
| Long term toxicity of sodium nitroprusside |
|
Definition
| conversion to cyanide and thiocyanate |
|
|
Term
| This drug prevents accumulation of cyanide |
|
Definition
|
|
