Term
| Drugs can have what affects on neurotransmitters(6)? |
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Definition
1) Allow neurotransmitters to leak out of the storage vesicle
2) Block newly synthesized neurotransmitters from entering the storage vesicle
3) Block the synthesis of the neurotransmitter
4) Block the uptake of the released neurotransmitters
5) Block the binding of the neurotransmitter to its receptor on post-synaptic membranes
6) Blok the release of the neurotransmitter |
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Term
| In order to be classified a neurotransmitter, a molecule must meet what criteria (7)? |
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Definition
1) small, water soluble molecule
2) stored in synaptic vesicles
3) act through receptors
4) Present in the synaptic cells at the appropriate concentrations
5) Enzymes that synthesize them must be present in the synaptic cells
6) Demonstrate that the chemical is released upon appropriate stimulation
7) Artificial application of the candidate molecules at a post-synaptic membrane will induce the expected response |
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Term
| What three neurotransmitters can be classified as Catecholamines? |
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Definition
| Dopamine, Norepinephrine, and Epinephrine- all three are derived from tyrosine |
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Term
| What neurotransmitter is found at nerve-muscle junctions for all voluntary muscles, and many involuntary muscles? |
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Definition
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Term
| What disease is a result of this auto-antibodies directed against the acetylcholine receptors? |
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Definition
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Term
| What is the function of monoamine Oxidase(MAO) inhibitors? |
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Definition
| function to keep the neurotransmitter in an active form for longer than intended (first used to treat depression) |
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Term
| How do you inactivate catecholamines? |
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Definition
1) reuptake at the synapse
2) chemical modification -such as by MAO(monamine oxidase) inhibitors |
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Term
| How do you in activate serotonin? |
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Definition
1) reuptake
2) MAO inhibitors |
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Term
| What can help relieve depression? |
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Definition
| elevated serotonin and norepinephrine |
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Term
| Zoloft, Paxil and Prozac do what? |
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Definition
| They are selective serotonin reuptake inhibitors, so slow the reuptake of serotonin |
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Term
| Trycyclics(eq imupramine) do what? |
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Definition
| They block reuptake of norepinephrine and serotonin |
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Term
| How do you inactivate GABA? |
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Definition
| reuptake and then converted to succinate in the synapse |
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