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Neuroscience
lesions
91
Science
Not Applicable
04/01/2008

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Term
[image]
Definition
lateral corticospinal tract:
ipsilateral spastic paralysis/paresis, hypertonia, and hyper-reflexia in arm and leg; Babinski sign, clonus, clasp-knife response
Term
[image]
Definition
left capsular lesion
Term
[image]
Definition
lateral corticospinal tract:
ipsilateral spastic paralysis/paresis, hypertonia, and hyper-reflexia in leg; Babinski sign, clonus
Term
[image]
Definition
1. Corticospinal tract: Contralateral spastic hemiplegia accompanied by exaggerated myotatic reflexes, increased resistance to passive stretch, and an extensor plantar response
2. Corticobulbar tract: Contralateral lower facial muscle paralysis
Term
[image]
Definition
1. Corticospinal tract: Contralateral spastic hemiplegia accompanied by exaggerated myotatic reflexes, increased resistance to passive stretch, and an extensor plantar response
2. Corticobulbar tract: Contralateral lower facial muscle paralysis
3. Abducens nerve: Medial deviation (esotropia) and abductor paralysis of ipsilateral eye
Term
[image]
Definition
1. Corticospinal tract: Contralateral spastic hemiplegia accompanied by exaggerated myotatic reflexes, increased resistance to passive stretch, and an extensor plantar response
2. Hypoglossal nerve: Paralysis, atrophy, and deviation of protruded tongue to ipsilateral side
Term
[image]
Definition
1. Corticospinal tract: Contralateral spastic hemiplegia accompanied by exaggerated myotatic reflexes, increased resistance to passive stretch, and an extensor plantar response
2. Oculomotor nerve: Ipsilateral ptosis and ophthalmoplegia with eye turned down and out (mydriasis also, owing to visceromotor fibers in CN III)
Term
complete spinal cord transection
Definition
1. All voluntary movements are lost, completely and permanently.
2. All sensations are lost, completely and permanently.
3. All reflexes involving the isolated spinal cord segments are temporarily abolished.
Term
Decerebrate posture of comatose patient
Definition
upper and lower limbs extend
Term
Decorticate posture of comatose patient
Definition
upper limbs flex, lower limbs extend
Term
[image]
Definition
Decerebrate:
lesion or infection at or below red nucleus
Term
[image]
Definition
Decorticate:
lesion or infection above red nucleus
Term
decorticate to decerebrate
Definition
damage has spread to red nucleus
Term
decerebrate to decorticate
Definition
damage has receded back past red nucleus
Term
[image]
Definition
blindness in damaged eye
Term
[image]
Definition
bitemporal heteronymous hemianopsia (tunnel vision)
Term
[image]
Definition
contralateral homonymous hemianopsia
Term
dorsal optic radiation or cuneus
Definition
contralateral homonymous anopsia in the inferior quadrant
Term
ventral optic radiation (loop of Meyer) or lingual gyrus
Definition
contralateral homonymous anopsia in the superior quadrant
Term
cochlear nuclei
Definition
ipsilateral deafness
Term
lateral lemniscus, brachium of the inferior colliculus, or auditory radiation
Definition
loss of sound localization, but no significant hearing loss
Term
solitary nucleus
Definition
ipsilateral ageusia
Term
secondary gustatory tract near medial lemniscus, or gustatory radiation
Definition
contralateral ageusia
Term
ataxia
Definition
intention tremor, dysmetria (overshoot target), dysdiadochokinesia (can't do rapid movements very well), explosive speech
Term
posterior lobe of cerebellum
Definition
ipsilateral ataxia especially in the distal muscles
Term
anterior lobe of the cerebellum
Definition
ipsilateral ataxia in lower limbs (gait ataxia)
Term
flocculonodular lobe of cerebellum
Definition
truncal ataxia
Term
orbitofrontal cortex
Definition
impulsive behavior, easily addicted to things like gambling and drugs
Term
[image]
Definition
Posterior lobe syndrome: Intention tremor. To and fro movements perpendicular to intended direction of movement.
Term
[image]
Definition
Anterior lobe syndrome: Gait ataxia. Clumsy movements of lower limbs
Term
[image]
Definition
Flocculonodular lobe syndrome: Truncal ataxia. Standing on wide base and reeling from side to side.
Term
[image]
Definition
Anterior cerebellar lobe (lower limb area): Gait ataxia
Term
[image]
Definition
Superior cerebellar peduncle (before decussation): Posterior lobe syndrome; ipsilaterally—intention tremor, dysmetria, dysdiadochokinesia, and so forth
Term
[image]
Definition
Flocculonodular lobe: Truncal ataxia
Term
left hemisection of spinal cord at T10
Definition
Tactile, vibration, and proprioception senses below the umbilicus on the left side and pain and temperature sensations below the inguinal ligament on the right side
Term
ventral white commissure from T2 to T4
Definition
Pain and temperature sensations bilaterally at the level of the nipples
Term
left ventral posterior nucleus
Definition
Tactile, proprioception, pinprick, and temperature senses on the entire right side
Term
right paracentral lobule
Definition
Loss of tactile and proprioception senses and some diminution of pinprick and temperature sensations and their precise localization, all in the left lower limb. Only precise localization and fine tactile discrimination depend on an intact primary somatosensory cortex for recognition.
Term
Nystagmus
Definition
involuntary rhythmic movements of the eyes that include two components: a slow drifting away from the target and a fast return to the target, upon irrigation of the ear (COWS is normal)
Term
a 15-year-old girl became obese and listless, had episodes of high fever without apparent cause, ceased menstruating, drank copious amounts of water owing to severe thirst, passed excessive amounts of urine, frequently fell asleep during the day, often had reversed sleep–wake cycles, and on occasion erupted into a violent state of rage without provocation.
Definition
damage to hypothalamus
Term
weak and hoarse voice accompanied by sagging of the left soft palate
Definition
The vagus nerve supplies the muscles of the vocal cords and soft palate. A left vagal palsy results in a weak, hoarse voice and sagging of the left soft palate.
Term
weakness in depression of the adducted right eye
Definition
The trochlear nerve supplies the superior oblique muscle. A right trochlear palsy results in impaired depression of the adducted right eye. If this abnormality were caused by a nuclear lesion, it would be on the left side because the trochlear nerve is crossed.
Term
on protrusion the tongue deviates to the left side
Definition
The hypoglossal nerve supplies the intrinsic muscles of the tongue. A left hypoglossal palsy results in paralysis of the left genioglossus muscle, thereby allowing the intact right genioglossus to deviate the protruded tongue toward the side of the lesion
Term
right facial hemianesthesia
Definition
The right trigeminal nerve with its ophthalmic, maxillary, and mandibular divisions carries somatosensations from the right side of the face (except the angle of the mandible), and its damage results in right facial hemianesthesia.
Term
esotropia and paralysis of abduction of the right eye
Definition
The right abducens nerve supplies the right lateral rectus muscle whose paralysis results in the absence of abduction in the right eye accompanied by esotropia caused by the pull of the normal medial rectus muscle.
Term
loss of taste on the posterior third of the left side of the tongue
Definition
The left glossopharyngeal nerve carries gustatory impulses from taste buds in the posterior third of the left side of the tongue and, when damaged, ageusia occurs in this area.
Term
[image]
Definition
ipsilateral, segmental hypotonia, paralysis/paresis, fasciculations
Term
[image]
Definition
contralateral spastic paralysis/paresis, Babinski resopnse, hypertonia, hyper-reflexia, and clonus in leg; arms are normal, contralateral face is normal
Term
Lateral corticospinal tract
Definition
Upper motor neuron syndrome: includes spastic paralysis, hypertonia, exaggerated reflexes, Babinski sign, clonus, etc. in all ipsilateral muscles below the lesion
Term
Ventral horn
Definition
(lower motor neuron syndrome) Ipsilateral flaccid paralysis, hypotonia, muscle fasciculations, absence of reflexes in the muscles supplied by this spinal segment
Term
Dorsal column of spinal cord
Definition
Loss of tactile, vibration, limb position and motion senses in the ipsilateral side below the lesion
Term
Spinothalamic tract (anterolateral system)
in spinal cord
Definition
Loss of fast pain and temperature in the contralateral side below the lesion
Term
Dorsolateral fasciculus (tract of Lissauer)
Definition
Loss of fast pain and temperature in the ipsilateral dermatomes supplied by this spinal cord segment and neighboring spinal cord segments
Term
Ventral (anterior) white commissure
Definition
Bilateral loss of fast pain and temperature in the dermatome supplied by this spinal segment
Term
Cuneate fasciculus and nucleus
Definition
Loss of tactile, vibration, limb position and motion senses in the ipsilateral upper limb
Term
Spinal trigeminal tract
Definition
Loss of fast pain and temperature in the ipsilateral face
Term
Gracile fasciculi and nuclei
Definition
Loss of tactile, vibration, limb position and motion senses in both lower limbs
Term
Hypoglossal nucleus and nerve
Definition
Paralysis/paresis and atrophy of ipsilateral tongue muscles. The tongue deviates to the ipsilateral side when protruded
Term
Pyramids
(corticospinal tract)
Definition
Upper motor neuron syndrome: spastic paralysis, hypertonia, exaggerated reflexes, Babinski sign, clonus, etc. in all contralateral muscles below the lesion (in this case, both upper and lower limbs).
Term
Medial lemniscus
Definition
Contralateral loss of tactile, vibration, limb position and motion senses in all regions below the lesion
Term
Trigeminothalamic tract
Definition
Loss of fast pain and temperature in the contralateral face
Term
Ambiguus nucleus
Definition
Hoarse voice, difficulty swallowing (dysphagia), lack of a gag reflex on the ipsilateral side, the uvula deviates to the contralateral side
Term
Spinal trigeminal tract
Definition
Loss of fast pain and temperature in the ipsilateral face
Term
Cranial nerve VIII (vestibular portion) and the vestibular nuclei
Definition
Loss of balance, loss of the vestibulo-ocular reflex
Term
Cranial nerve VIII (cochlear portion) and the cochlear nuclei
Definition
Ipsilateral loss of hearing
Term
Inferior cerebellar peduncle
Definition
Ipsilateral ataxia (especially of the lower limb), gait instability, loss of balance and equilibrium
Term
Facial nerve (CN VII) and the facial nucleus
Definition
Flaccid paralysis/paresis and lower motor syndrome of the ipsilateral facial muscles of expression. Dry eyes and dry mouth (due to lack of lacrimation and salivation). There may also be a loss of taste from the anterior portion of the ipsilateral tongue (ageusia).
Term
Abducens nerve (CN VI)
Definition
Ipsilateral eye deviated medially
Term
Principal sensory nucleus (trigeminal)
Definition
Loss of tactile and vibration senses in the ipsilateral face
Term
Corticospinal tract (in pons)
Definition
Upper motor neuron syndrome: includes spastic paralysis, hypertonia, exaggerated reflexes, Babinski sign, clonus, etc in all contralateral muscles below the lesion (in this case, both upper and lower limbs).
Term
Trigeminal motor nucleus
Definition
Paralysis/paresis and atrophy of ipsilateral muscles of mastication. The jaw deviates to the ipsilateral side.
Term
Trochlear nerve (CN IV)
Definition
Ipsilateral eye is rotated outward. The patient tilts his/her head to the contralateral shoulder to compensate
Term
Superior cerebellar peduncle
Definition
Posterior cerebellar lobe syndrome (ipsilateral intention tremor, dysmetria, ataxia of the upper and lower limbs, dysdiadokokinsis, etc)
Term
Medial geniculate nucleus
Definition
Slight loss of hearing. Difficulty localizing sounds.
Term
Lateral geniculate nucleus
Definition
Loss of vision in the contralateral visual hemifield (contralateral homonymous hemianopsia)
Term
Oculomotor nucleus and nerve (CN III)
Definition
Ipsilateral eye is deviated downward and laterally. Droopy eyelid (ptosis) on the ipsilateral side. Because of involvement of the Edinger-Westphal nucleus, the ipsilateral pupil will be dilated.
Term
Red nucleus
Definition
Slight movement disorder (paresis/weakness) in the contralateral limbs. Ataxia of the contralateral limbs (especially the lower limb) may also be present because of anterior cerebellar lobe syndrome.
Term
Internal capsule
Definition
-Corticospinal tract: upper motor neuron syndrome in contralateral muscles of both upper and lower limbs and of the trunk. Upper motor neuron syndrome includes spastic paralysis, hypertonia, exaggerated reflexes, Babinski sign, clonus, etc.

-Corticobulbar tract: Contralateral paralysis/paresis of the contralateral lower face muscles

-Thalamocortical radiations: Loss of all somatosensations from the contralateral body and face
Term
Hippocampal formation and the parahippocampal gyrus
Definition
Memory deficits, especially in the consolidation of short-term memory into long-term memory
Term
Gustatory cortex
Definition
Ageusia (loss of taste)
Term
Auditory cortex
Definition
Slight hearing loss, difficulty localizing sounds
Term
Basal ganglia (putamen and globus pallidus)
Definition
Movement disorder similar to Huntington’s Disease (hyperkinesia, chorea, athetosis)
Term
Dorsal portion of the postcentral gyrus
Definition
Loss of all somatosensation from the contralateral upper limb
Term
Dorsal portion of the precentral gyrus
Definition
upper motor neuron syndrome in muscles of the contralateral upper limb
Term
Posterior parietal lobe
Definition
Contralateral tactile agnosia, visual agnosia, and hemineglect syndrome
Term
Wernicke’s area
Definition
Wernicke’s aphasia (comprehension aphasia) – fluent, but incoherent language; inability to comprehend language, etc.
Term
Visual cortex and visual association cortex
Definition
Loss of vision in the contralateral visual hemifield (contralateral homonymous hemianopsia)
Term
gustatory radiation, parietal operculum, or ventral posteromedial nucleus
Definition
contralateral ageusia
Term
solitary nuclues or tract
Definition
ipsilateral ageusia
Term
olfactory bulbs
Definition
anosmia
Term
failure of the basal nucleus of Meynert is a precurser to _____
Definition
Alzheimer's disease
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