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Neuroscience Final Exam #3/6
Neuroscience Final Exam #3/6
30
Psychology
Undergraduate 3
12/12/2012

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Term
the
learning of a motor response in
reaction to sensory input.
Definition
Procedural learning
Term
Nonassociative learning (2)
Definition
habituation and sensitization
Term
over time a
stimulus has less and less impact
on behavior.
Definition
habituation
Term
a strong sensory
stimulus leads to increased
responsiveness to other sensory
stimuli.
Definition
sensitization
Term
Association of a stimulus that evokes a response with another stimulus that does not evoke this response.
Definition
Classical conditioning
Term
US and CS must be simultaneous, or CS may
precede US by a short interval. If CS follows US !92 no conditioning.
Definition
timing requirement of classical conditioning
Term
Classical conditioning involves learning a
Definition
predictive relationship
Term
learning to associate a motor response with a
meaningful stimulus (e.g. a reward). learning the association between particular behaviors and their outcomes
and consequences. The behavior must occur slightly before the stimulus
Definition
instrumental conditioning
Term
The 1Cstar 1D of invertebrate learning models
Definition
Aplysia californica (slug like)
Term
The nervous system of Aplysia contains about how many neurons?
Definition
18,000-20,000
Term
: The gill
withdrawal reflex in Aplysia shows
Definition
habituation
Term
Cell
L7 in the abdominal ganglion receives
sensory input and connects to muscles.
Definition
Habituation of the gill withdrawal reflex
Term
Human memory involves structures in the
Definition
hippocampus and in the
temporal lobes of the brain
Term
Hippocampal cells show
Definition
LTP and LTD
Term
record from cell in hippocampus area CA1
(receives Schaffer collaterals from area CA3). In addition, stimulate
two sets of input fibers
Definition
Typical LTP experiment
Term
LTP is (2)
Definition
input specific and long-lasting
Term
LTP results when
Definition
synaptic stimulation coincides with postsynaptic
depolarization
Term
synaptic stimulation coincides with postsynaptic
depolarization is acheived by
Definition
cooperativity of many coactive
synapses during tetanus
Term
LTP may produce
Definition
synaptic 1Csprouting 1D
Term
LTP has what kind of characteristics?
Definition
Hebbian ( 1Cwhat fires together wires
together 1D, or, in this case, connects together more strongly)
Term
Hippocampal responses can be modified in the direction of
Definition
potentiation
(LTP) and depression (LTD)
Term
Long-term depression (LTD) in the hippocampus, triggered by
Definition
a lowfrequency tetanus:
Term
Most of the mechanisms of LTP/LTD are shared between
Definition
hippocampus and cortex
Term
LTP/LTD play a role in synaptic rearrangements during
Definition
development
and also during memory formation in the adult brain.
Term
How can one 1Cprove 1D that LTP/LTD underlie memory? (2)
Definition
1. Probing and stimulating/blocking of the molecules involved in
LTP, especially the NMDA receptor.

2. Observing the effects of these manipulations on learning and
behavior
Term
standard test for spatial
memory in rodents
Definition
Morris water maze
Term
Rats with __________cannot learn/remember the
location of the hidden platform.
Definition
bilateral hippocampal damage
Term
Injection of ________ into the hippocampus also abolishes
behavioral improvement and learning (Richard Morris)
Definition
NMDA blockers
Term
genetic manipulation of
genes that make molecules thought to be involved in learning and
memory
Definition
Gene knockout can be restricted to specific regions of the
brain
Term
Does boosting the number of NMDA receptors produce an increase
in memory performance?
Definition
Overexpression of NMDA receptors in
genetically altered mice can result in enhanced learning (Joe Tsien,
1999).
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