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Neuroscience Exam 4 Diseases
Diseases and conditions for Neuroscience Exam 4
41
Medical
Professional
05/12/2011

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Term
ADHD
Definition
Neurobehavioral development disorder, impulsivity/inattention/hyperactivity, adults do not show motor hyperactivity, show abnormally small prefrontal cortex and caudate, alcohol/tobacco use in pregnancy and genetic factors
Term
Normal Difficult Behavior 6-12
Definition
arguments/fights, genitalia curiosity, testing limits, poor attention span, worrying about accepted, lying, no responsibility
Term
Normal Difficult Behavior 13-18
Definition
moody, less attention/affection to parents, self-involved, peer conflicts, relationship stress, testing limits, identity searching, substance experimentation, sex preoccupation
Term
Mental Retardation (MR)
Definition
IQ<70, onset before 18 yo, Mild form (85%, IQ 50-70), Moderate form (10%, IQ 35-50), Severe form (3%, IQ 20-40), profound form (1-2%, IQ<25), global deficits
Term
Elimination disorders
Definition
must be relapsed from previous potty training, encopresis (feces) >4 y.o. with or without incontinence/constipation, enuresis (urine) >5 y.o. nocturnal/diurnal/both
Term
Feeding/eating disorders
Definition
Pica (eating nonnutritive substances >1 mo with vitamin deficiencies of Fe/Zn), Rumination disorder (regurgitating and rechewing ood >1mo)
Term
Oppositional Defiant Disorder
Definition
negative/hostile/defiant behavior >6mo, 4 of temper/arguing/defying rules/annoying/blames others/easily annoyed/angre or resentful/spiteful or vindictive, more common male than femal 2/3:1, look for ADHD/depression/MR
Term
Conduct Disorder
Definition
behavior >12mo, 3 of aggression/destruction/deceit/rules violations/impaired, must be <18yo, more common in males 3/5:1, childhood (<10) and adolescent (>10) onset, can become Antisocial Personality Disorder
Term
ADHD
Definition
6 or more inattentive items/hyperactive or impulsive items, >6 months of impairment before 7yo, comorbid ODD/conduct disorder/anxiety/depression/bipolar, irritable/hyperactive/accelerated speech/distracted, NOT elated/grandiose/flight of ideas/less sleep/hypersexual, monitor height/weight/BP/HR while on stimulants, can treat with a-agonists (improved prefrontal function)
Term
Tic Disorders
Definition
sudden/rapid/recurrent/nonrhythmic motor or vocal movements, onset <18yo, >1 yr, never free more than 3mo, treat with a-agonishts/SSRIs/antipsychotis, Chronic motor/vocal tic disorder (single or multiple motor OR vocal tics), Tourette's Syndrome (multiple motor AND vocal tics), Transient Tic Disorder (motor/vocal tics every day for >4wk), Tic Disorder NOS (only partial criteria)
Term
Autism
Definition
2 qualitative social interactions impairments, 1 qualitative communication impairment, 1 repetitive behavior/interests/activiaties, must have >6 symptoms, more common in males, 75% MR, 25-30% seizures, increased head growth in 1st yr, treat aggression, teach communication/behavior skills/family intervention, caused by genetic and prenatal/perinatal exposure
Term
Asperger's Disorder
Definition
2 qualitative social interaction impairments, 1 repetitive behavior/interest/activity, NO communication or cognitive disabilities, treat similar to autism with better outcome, more common in males
Term
Rett's Disorder
Definition
loss of language/motor abilities between 6-18mo, more common in females, truncal incordination and flapping, 80& hav MeCp2 mutation on X chromosome acquired after conception
Term
Childhood Disintegrative Disorder
Definition
normal development to 2yo, loss of language/behavior/bowel or bladder control/motor skills, abnormal function of 2 of social interaction/communication/behavior patterns
Term
Major Depressive Disorder
Definition
more common in adolescent females 4:1, heredity of 1 affectively ill patient, 5 or more of SIGECAPS, 4-6 weeks before antidepressants work
Term
Childhood-onset Schizophrenia
Definition
<13 yo, hallucinations/delusions/disorganized behavior or speech, more common in males 2:1, gradual onset, contributions from genetics/family stress/depression, treat with antipsychotics/social skills training/family intervention, poor prognosis
Term
Early-onset Schizophrenia
Definition
>18 yo
Term
General Anxiety Disorder
Definition
excessive anxiety >6 mo, with irritability/aches/sleep difficulty/restless/decreased concentration/fatigue, NO decreased interest/decreased appetite/decreased esteem/suicide
Term
Panic Disorder
Definition
abrupt (<10min) episodes of intense anxiety, worry of implications of attacks, palpitations/chest pain/dizziness/faintness/overbreathing/nausea
Term
OCD
Definition
recurrent obsessions or behaviors, usually aware of excessive/unreasonable nature, markedly distressed, checking/counting/washing/collecting/doubting/symmetry preoccupation
Term
Social Anxiety Disorder
Definition
fear of social embarrassment, excessive and interferes with routing functions
Term
Post-traumatic Stress Disorder (PTSD)
Definition
re-lives trauma through flashbacks/nightmares/images/thoughts/dreams/cues, avoidance and numbing, >1 mo of symptoms, insomnia/irritability/hypervigilance/startled/decreased concentration
Term
Acute Stress Disorder
Definition
same as PTS but 2days-4weeks, 3 or more of detachment/decreased awareness/derealization/depersonalization/amnesia
Term
Medical causes of anxiety
Definition
thyroid, hypoglycemia, CHF, pheochromocytoma, COPD, pulmonary embolus, arrhythmia
Term
Anxiety
Definition
often secondary to psychiatric illness, limbic involvement (amygdala), intended to relax/induce drowsiness and sleep
Term
Bleuler's 4 A's of schizophrenia
Definition
autism, ambivalence, affect, associations
Term
Psychotic Dimension of schizophrenia
Definition
positive symptoms with distortion/exaggerated functions, loss of ego boundaries, unable to distinguish between internal/external, hallucinations (auditory most common, visual usually anatomic/metabolic cause), delusions (disturbance in inferential thinking)
Term
Disorganized Dimension of schizophrenia
Definition
distortion of normal behaviors, disorganized speech, specific thought symptoms, disorganized/catatonic motor behavior (uncontrolled or aimless), incongruous affect does not match circumstances
Term
Negative Dimension of schizophrenia
Definition
deficiency of mental function, similar to depression, lack of insight, premorbid adjustment corresponds to poor prognosis, comorbid substance abuse
Term
Paranoid Subtype
Definition
preoccupied with delusions/hallucinations, NO prominent disorganized behavior/flat affect
Term
Disorganized Subtype
Definition
disorganized speech and inappropriate affect, fragmented delusions/hallucinations, silly and childlike, early onset, negative symptoms progress, poor premorbid adaptation and prognosis
Term
Catatonic Subtype
Definition
motor/sensory/verbal symptoms, early onset, most chronic course, poor social functioning, less common now
Term
Schizophrenia Course
Definition
chronic, usually begins in adolescence, developmental delay and preference for solitary play, prodromal phase (gradual onset of social withdrawal/changes in behavior), active phase (psychotic symptoms predominate, diagnosis is made), residual phase (episodic exacerbated symptoms, may relapse into active phase), positive symptoms evolve into negative symptoms, deteriorating and never regain baseline functions
Term
Indicators of poor schizophrenia prognosis
Definition
social isolation, long active phase, history of episodes/treatment, unmarried, behavioral problems in childhood
Term
Schizophrenia epidemiology
Definition
prevlance rates similar internationally, males more common and earlier onset, lower socioeconomic status, 3/10 attempt suicide, 1/10 complete suicide
Term
Schizophrenia pathophysiology
Definition
genetic prevalence with family, ventricular enlargement (not diagnostic), disrupted functional circuits (PET scans help), disrupted feedback loops in prefrontal (executive function)/thalamus (filter)/ cerebellum (coordinating), possible disturbed neuronal migration, hyperactive dopamine circuit
Term
Schizophreniform Disorder
Definition
schizophrenia symptoms 1-6mo, prevents premature schizophrenia diagnosis
Term
Schizoaffective Disorder
Definition
concurrent schizophrenia with mood disorder
Term
Delusional Disorder
Definition
well-systemized non-bizarre delusion, delusions in absence of full schizophrenia symptoms, erotomanic (in love with)/grandiose/jealous/persecuotry/somatic delusions, may be mixed/unspecified/shared
Term
Positive Psychosis symptoms
Definition
hallucinations, delusions, extreme emotion, thought disorder, excited motor activity
Term
Negative Psychotic Symptoms
Definition
apathy, social withdrawal, self neglect, blunt affect, lack of emotion
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