Term
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Definition
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Term
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Definition
major stimulant, Immediately after DA depletion there is no effect on apomorphine stereotypy. Within a few days after DA depletion, apomorphine stereotypy is enhancedà Receptor supersensitivity. DA agonist used as a probe for PD but doesn't last long and can cause vomiting, therefore not used as a treatment.
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Term
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Definition
| degenerative disease, age-related, causes unknown |
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Definition
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Definition
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Definition
| toxic agent, a chemical made by heating, converted by MAO to MPTP which is toxic- affects SNc most |
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Definition
| caused by DA antagonists (haloperidol), reserpine, cholinomimetrics (used to treat Alz) |
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Definition
| replacement therapy for PD, most efficacious, least potent. It loses its therapeutic effect after long term use; causes psychosis, motor side effects such as dyskinesias. |
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Definition
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L-Dopa + carbidopa which block CA synthesis in periphery such as in the adrenal gland; treatment for PD |
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Definition
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Definition
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Definition
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Definition
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Definition
| weak partial D1 selective agonist; not anti-PD, therefore it was assumed that D1 agonists could not be used to treat PD. |
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Definition
| D1 agonist with more intrinsic effect that SKF 38393, maybe anti-PD |
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Term
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Definition
D1 agonist with more intrinsic effect that SKF 38393, maybe anti-PD
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Term
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Definition
| Non-DA agonist that is anti-PD; MAOB-I; anti-depressant in transdermal patch |
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Term
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Definition
| Non-DA agonist that is anti-PD; COMT-I |
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Term
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Definition
| muscarinic antagonist; anti-PD |
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Term
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Definition
muscarinic antagonist; anti-PD; also used to treat Alz side effects
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Term
| diphenhydramine (Benadryll) |
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Definition
| muscarinic antagonist and anti-histamine; anti-PD |
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Term
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Definition
| adenosine A2A antagonist; anti-PD |
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Term
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Definition
adenosine A2A antagonist; anti-PD
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Term
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Definition
| minor stimulant, non-selective adenosine antagonist; may have anti-PD effects |
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Definition
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Term
| d-amphetamine (Dexedrine) |
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Definition
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Term
| d- and l- amphetamine (Adderall) |
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Definition
ADHD treatment; resemic mixture
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Term
| methamphetamine (Desoxyn) |
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Definition
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Definition
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Definition
| selective NE uptake blocker; enhances attentional performance but not a psychomotor stimulant in the classic sense; limited abuse potential; approved for treatment of ADHD in 2002 |
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Term
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Definition
| 1st generation anti-psychotic; calming effect in animals; blocks MA storage- depletes MA |
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Term
| chlorpromazine (Thorazine) |
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Definition
| 1st generation anti-psychotic; found blunting of hallucinations and positive symptoms |
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Term
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Definition
| 1st generation anti-psychotic |
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Definition
1st generation anti-psychotic
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Definition
1st generation anti-psychotic
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Term
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Definition
| selective D1 antagonists; not anti-psychotic |
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Term
| clozapine (Clozaril, Leponex, Fazclo) |
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Definition
| atypical anti-psychotic; produces little motor side effect; blocks DA D1 and D2 receptors, also binds to alpha 1 and alpha 2 adrenergic receptors, and H1 histamine receptors, muscarinic ACh receptors, various 5HT receptors (inverse agonist on 5HT 2a and 2c); decreases tremor in some PD patients; produces agranulocytosis which can kill you, needs to be managed carefully; |
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Term
| L-745870 and sonepiprazole |
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Definition
| D4 antagonists; not anti-psychotic |
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Term
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Definition
| atypical anti-psychotic; acts on both D2 and 5HT |
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Definition
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Definition
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Definition
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Definition
| neuroprotective, NMDA antagonist, induces hallucinations and other psychotic symptoms that resemble schizophrenia |
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Term
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Definition
| MAO-I; anti-depressant; cannot be taken w/ tyramine- increases bp and risk of stroke; irreversible and non-selective for MAOB and MAOA |
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Term
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Definition
MAO-I; anti-depressant; cannot be taken w/ tyramine- increases bp and risk of stroke; irreversible and non-selective for MAOB and MAOA
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Term
| moclobemide (Moclobamine) |
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Definition
| new MAO-A selective anti-depressant, reversible inhibitor of MAO-A (RIMA) |
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Term
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Definition
| 1st generation anti-depressant; "tricyclic"; blocks MA uptake and acts on NE |
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Term
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Definition
1st generation anti-depressant; "tricyclic"; blocks MA uptake and acts on NE
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Term
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Definition
1st generation anti-depressant; "tricyclic"; blocks MA uptake and acts on NE
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Term
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Definition
1st generation anti-depressant; "tricyclic"; blocks MA uptake and acts on NE
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Term
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Definition
| SSRI; 2nd and 3rd generation anti-depressant |
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Term
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Definition
SSRI; 2nd and 3rd generation anti-depressant
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Term
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Definition
MA uptake inhibitor; 2nd and 3rd generation anti-depressant; acts on 5HT and NE
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Term
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Definition
| MA uptake inhibitor; 2nd and 3rd generation anti-depressant; acts on 5HT and DA |
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Term
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Definition
| MA uptake inhibitor; 2nd and 3rd generation anti-depressant; also called Zyban for smoking cessation; acts on DA and NE but more on DA |
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Term
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Definition
| MA uptake inhibitor; 2nd and 3rd generation anti-depressant; acts on DA and NE |
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Term
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Definition
| DA antagonist used to treat bipolar disorder, seroquel, risperdal, zyprexa, and geodon are antipsychotics used to treat it too |
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Definition
| mood stabilizer, possibly related to decreased c-AMP and IP3 signaling |
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Term
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Definition
| anti-convulsant used to treat bipolar disorder |
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Definition
anti-convulsant used to treat bipolar disorder
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Term
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Definition
| anti-AChesterase; tends to increase depression and decrease mania |
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Definition
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Term
| chlodiazepoxide (Librium) |
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Definition
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Term
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Definition
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Definition
anxiolytic BDZ, helps with panic attacks
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Definition
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Definition
| beta-carbolin BDZ inverse agonist; proconvulsant, proconflicts, anxiogenic, increased cortisol (stress response) |
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Term
| diazepam binding inhibitor (BDZ) |
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Definition
| endogenous substance that binds to BDZ receptor, produce proconflict effects in rats |
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Term
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Definition
| new atypical drug that is selective for anxiety, fewer side effects; similar to clozapine; 5HT1A receptor agonist; a azapirone |
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Term
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Definition
| azapirone, has anxiolytic effects |
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Term
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Definition
| new atypical drug that is selective for anxiety |
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Term
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Definition
azapirone, has anxiolytic effects
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Term
| varenicline (Chanitix or Champix) |
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Definition
| long acting partial nicotinic agonist; block the effects of nicotine from smoking; used for smoking cessation |
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Term
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Definition
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Term
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Definition
| sedative hypnotic; barbituate |
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Term
| choral hydrate "micky finn" |
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Definition
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Term
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Definition
| sedative hypnotic; lethal and explosive |
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Term
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Definition
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Definition
Ethanolà(ADH or catalase)àacetaldehydeà(ALDH)à acetate
sedative hypnotic |
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Term
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Definition
| inhibits peripheral metabolism, produces aversions to ethanol after intake; mixed results; can develop a tolerance to it |
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Term
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Definition
| opiate antagonists, thought to reduce euphoria and craving from sedative hypnotics |
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Definition
opiate antagonists, thought to reduce euphoria and craving of alcohol
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Term
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Definition
| used for alcohol treatment; mixed results |
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Definition
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Definition
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Definition
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Definition
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Definition
| THC in pill for, slower acting, difficult to control to dosage |
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Definition
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Definition
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Definition
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Definition
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Definition
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Definition
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Term
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Definition
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Definition
| used as a substitution therapy for opiate addiction, gradually reduced |
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Term
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Definition
| khat; naturally occurring abused major stimulant |
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Term
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Definition
| synthetic derivative of methcathione |
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Term
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Definition
| special K, dissociative anesthetics |
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Term
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Definition
| PCP, dissociative anesthetics |
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Term
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Definition
| MA type hallucinogen; from peyote cactus |
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Term
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Definition
| MA type hallucinogen, in nutmeg and mace |
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Term
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Definition
| amph derivative; hallucinogen |
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Term
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Definition
amph derivative; hallucinogen; mellow drug of America
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Term
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Definition
amph derivative; hallucinogen
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Term
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Definition
ecstasy; amph derivative; hallucinogen
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Term
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Definition
| indole hallucinogen; from Psilocybe mushrooms |
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Term
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Definition
| indole hallucinogen; ayahuasaca drink; from the Amazon |
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Term
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Definition
| from the glands of the toad Bufo alvarius; indole hallucinogen |
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Term
| lysergic acid diethylamide (LSD) |
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Definition
| acid; synthetic hallucinogen |
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Term
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Definition
| "foxy methoxy"; synthetic hallucinogen |
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