Term
| Ligand Binding Methods- subtyping |
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Definition
(using a radioactive labelled ligand) this is a Method of classifing Drugs by Identifing their receptor and location .
E.g. Morphine Binds to receptor which decreases pain sensation- same receptor and location as the Opiod Neurotransmitters
***
New research in the US, focusing on the pharmacological aspects of smoking marijuana, are closer to understanding how the drugs active ingredients exert its effects, paving the way for drugs that selectively bind and block subtypes of cannabinoid receptors on one type of cell but not another. |
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Term
Endorphins are "endogenous" which means they are
a.produced inside body
These endorphins make effects when they attach to which (clue: Morphine-like effects) NT receptors? |
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Definition
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Term
| Antagonist opiod receptors have this effect |
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Definition
occupies the receptor
without opiod analgesic effects. |
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Term
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Definition
| A neuropeptide that is a type of endorphin. (CNS)Neurons containing the enkephalins are even more widely distributed in the central nervous system. Levels are particularly high in the dorsal horn of the spinal cord, a region that contains opiate receptors and is involved in the transmission of pain (see Chap. 11). Enkephalins may act at this location to inhibit pain transmission by sensory nerves |
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Term
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Definition
agonis antagonist
nicotine Ach curare
msucarnic Ach atropine |
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Term
| Glutamate vs. (AMPA and NMDA) |
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Definition
| can bind to any channel vs. receptor specific |
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Term
Norepinephrine Alpha=
Norepineprhine Beta= |
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Definition
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Term
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Definition
To assess the postsynaptic actions of a neurotransmitter candidate
e.g. ionophoretic application
1. electrophysiological changes
2. Determine if it mimics effect of transmitter
Criteria: localization, synthesis and release |
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Term
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Definition
| localize MRNA transcripts through applying radioactive label probes |
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Term
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Definition
| various receptors, various effects |
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Term
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Definition
| 4 transmitter 3 receptors one effector |
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Term
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Definition
| 2 receptors mix into 5 effectors |
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Term
| The fucnction of signal cascades |
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Definition
| Signal amplification by G-Protein coupled second messenger cascades |
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Term
| The function of signal cascades |
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Definition
| Signal amplification by G-Protein coupled second messenger cascades |
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Term
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Definition
| Kinase driven- provides- a confirmational change |
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Term
| long term depression vs. long term potentiation |
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Definition
| depends on prestimulus and amount of Ca+2 released |
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Term
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Definition
at high extraculluar concentrations- causing an increase in Ca2+ pathological
high Ca2+ activates proteases and destroys neurons |
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Term
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Definition
| Heart attack, blocks glutamate- for Ca+2 extra cellular- |
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Term
| slow synaptic transmission |
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Definition
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Term
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Definition
| specific NT- confirmational change- it binds |
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Term
| integral membrane protein (expands membrane) NT binding sites- then what? |
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Definition
| binding changes shape, g-protein- inside of the membrane- NO NT, NO G-PROTEIN |
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Term
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Definition
alpha beta gamma subunits
anchored to membrane- |
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Term
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Definition
| binding site GDP bound when activated |
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Term
| when it bound by G-protein- NTs, loses affinity for GDP neucleotide, fall off and now has a high affinity for GTP |
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Definition
| activation of the G-Protein- binds to an activated receptor - a receptor with a NT bound to it |
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