Term
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Definition
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Term
|
Definition
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Term
|
Definition
| blocks Na+ voltage gated channels |
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Term
|
Definition
| inhibits HVA Ca2+ channels (although designed as GABA analog) |
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Term
|
Definition
| blocks Na+ channels, increases GABA |
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Term
|
Definition
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Term
| Mechanism of benzodiazepines |
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Definition
| Increases GABAA action by increasing frequency of Cl- channel opening |
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Term
|
Definition
Increases Na+ channel inactivation
Increases GABA concentration |
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Term
Ethosuximide
Use and mechanism |
|
Definition
Absence seizures
Blocks thalamic T-type Ca2+ channels |
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Term
|
Definition
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Term
|
Definition
| Irreversibly inhibits GABA Transaminase leading to increased GABA |
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Term
| Anti-epileptic p450 induces |
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Definition
| carbamazipine, phenobarbitol, phenytoin |
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Term
|
Definition
| facilitate GABAA via increases duration of Cl- channel opening |
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Term
|
Definition
| alpha-adrenergic antagonist |
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Term
| anti-epileptic that can cause SIADH |
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Definition
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|
Term
| Urticaria, hearache, fatigue, GI upset after anti-epileptic |
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Definition
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|
Term
| nystagmus, diplopia from anti-epileptic |
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Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
| kidney stones from anti-epileptic |
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Definition
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|
Term
| anti-epileptic causing gingival hyperplasia |
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
high potency
high lipid solubility
Rapid entry into brain
Rapid redistribution into tissue and fat |
|
|
Term
| Most common drug used for endoscopy |
|
Definition
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Term
|
Definition
| Arylcyclohexylamine - dissociative anesthetics, block NMDA receptors |
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|
Term
| IV anesthetic that increases cerebral blood flow |
|
Definition
|
|
Term
| IV anesthetic that potentiates GABAA |
|
Definition
|
|
Term
| local anesthetic mechanism |
|
Definition
| block Na+ on specific receptors on inner portion or channel. preferentially bind to activated Na+ channels |
|
|
Term
| Order of nerve blockade by local anesthetics |
|
Definition
| small myelinated fibers>small unmyelinated fibers>large myelinated fibers>large unmyelinated fibers |
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|
Term
| local anesthetic with cardiovascular toxicity |
|
Definition
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|
Term
| Depolarizing neuromuscular blocker |
|
Definition
|
|
Term
| complications of succinylcholine |
|
Definition
| hypercalcemia and hyperkalemia |
|
|
Term
Treatment for malignant hyperthermia
Mechanism? |
|
Definition
| Dantrolene - prevents release of Ca2+ from SR of skeletal muscle |
|
|
Term
| entacapone, tolcapone mechanism |
|
Definition
| COMT inhibitors, prevent L-dopa breakdown |
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Term
|
Definition
|
|
Term
| Alzheimer's meds which cause insomnia |
|
Definition
| AcetylCholinesterase inhibitors (Donepezil, galantamine, rivastigmine) |
|
|
Term
| Headache medication that can cause coronary vasospasm |
|
Definition
|
|
Term
|
Definition
agonist to opioid receptor (mu - gprotein coupled, delta, and kappa), opens K+ channels, closes Ca2+ channels, decreasing synaptic transmission
Inhibits release of Ach, NE, 5-HT, glutamate, substance P |
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Term
|
Definition
| partial agonist at opioid mu receptors, agonist at Kappa receptors |
|
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Term
|
Definition
| very weak opioid agonist, inhibits serotonin and NE reuptake. |
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Term
| Epinephrin - use in glaucoma |
|
Definition
| decreases aqueous humor synthesis due to vasoconstriction |
|
|
Term
| brimonidine - use in glaucoma |
|
Definition
| decrease aqueous humor synthesis (alpha-agonist) |
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|
Term
| timolol mechanism - glaucoma |
|
Definition
| beta-blocker, decreases aqueous humor secretion |
|
|
Term
| Acetazolamide mechanism - glaucoma |
|
Definition
diuretic, carbonic anhyrdase inhibitor
decreases aqueous humor secretion by decreasing HCO3- |
|
|
Term
| pilocarpine mechanism in glaucoma |
|
Definition
direct cholinomimetic
- increase outflow of aqueous humor
- contract ciliary muscle and open trabecular meshwork |
|
|
Term
| carbachol mechanism - glaucoma |
|
Definition
| direct cholinomimetic, increase outflow of aqueous humor, contract ciliary muscle and open trabecular meshwork |
|
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Term
|
Definition
indirect cholinomimetic (anticholinesterase)
increases outflow of aqueous humor by contracting ciliary muscle and opening trabecular meshwork |
|
|
Term
|
Definition
| increases outflow of aqueous humor, as a PGF-2alpha (prostoglandin) |
|
|
Term
| glaucoma med that darkens iris |
|
Definition
|
|
Term
| Need to test what in lithium? |
|
Definition
TSH, BUN creatinine
Lithium also can cause nephrogenic diabetes insipidus |
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